No more brother wars
Whatever I was expecting to happen, it wasn’t that.
Ecosocialist praxis
I support you poison Ivy
Reblog if you support Poison Ivy
That’s my girl.
Joking aside, the Millennium Falcon is not the space fantasy equivalent of a busted-ass old panel van.
The Millennium Falcon is the space fantasy equivalent of a busted-ass old panel van that's inexplicably been hot-rodded to have a top speed of 300 miles per hour, which is substantially funnier.
im not the unreliable narrator im the narrator who stepped up
I died but I came back exactly the same. You though, I came back and you were wrong. Did the fact of my dying really damage you that much? Was bringing me back worth what it cost you? Would it have been better to just leave me?
Ooo I got calced
I think parents should teach their toddlers the phrase “my will has been thwarted” for when they’re feeling frustrated by not getting what they want. I don’t think this would reduce the incidence of temper tantrums, but I do think it would make them more entertaining.
Thing about tumblr is you and your friends see one post and then suddenly none of you can spell "package" right ever again
cat-sitting comix
Is this a prank? What….
Edit: holy heck it’s real…
They might be able to help us…
The stage that they're at is animal testing but it sounds like it's been successful in mouse and primate models.
My understanding: The way autoimmune diseases usually seem to work* is the immune system is "flagging" the wrong thing as harmful/not needed and destroying it. The typical treatments for autoimmune diseases are just tamping the entire immune system down so it can't destroy anything, which leaves a person vulnerable to infection.
The newer method is basically "tricking" the body using a method that... the human body already came up with. Cells flagging the wrong thing apparently happens all the time, so there are multiple defenses against immune disease, and one of them is in the liver. So scientists figured out a way to tell the body "hey, you flagged this wrong" and sent it to the liver and the liver/body recognized this signal.
There is still a lot of work to be done and it sounds like this isn't foolproof (ie: what if the liver is whats broken? unsure, and what if the immune system flags things wrong again?) but this is literally so amazing. i was tearing up reading it, and i hope that everything goes well in clinical trials.
*theres like a lot medical science doesnt know about the immune system
Thank you for this explanation/synthesis of the article! It's important for us to understand that they're still in early development and testing of these methods, but also that they've seen it work in mice and primates (rather than just petri dishes of human cells). I hope this goes well.
Hi! I'm a microbiologist and I've done work in academia, pharma, and clinical trials.
So the most exciting thing about this article is the last paragraph tbh (working on getting the actual paper, it's not up on sci-hub yet).
The company mentioned, Anokion, has four registered clinical trials for both Celiac and MS patients. The trial for Celiac just submitted data from their phase 1 trial (meaning there's good data it is safe) and are recruiting for a Phase 1/2 trial (meaning they are now testing efficacy). After that, the big hurdle is phase 3, which looks at whether or not it is better than a current treatment. The projected completion date is spring 2025. They are also preparing for a Phase 2 trial but are not yet recruiting.
The phase 1 MS trial is currently active, estimated completion in summer 2024.
I checked the company website and it looks like they are in the process of submitting an investigational new drug (IND) application for Type 1 diabetes. This is the first step to starting clinical safety and efficacy trials.
Now clinical trials can get delayed for a variety of reasons, but this is a really good sign! It's way further along than I initially thought when seeing the news. If the treatment does well, we could see new drugs on the market for Celiacs as early at 2030ish and MS as early as 2035.
@giftober 2023 | DAY 7: WATER
Water shots in Avatar: The Last Airbender
The one and only, Harley Quinn! By Mindy Lee
Does any horror story about small towns capture the vibe more horrifyingly than this paragraph on Wikipedia
This small farming community is known for its mob killing, its unsolved murders, its unsolved disappearances, and the annual pumpkin festival
big bro must protec
still thinking about King Phantom with a halo....
Best part is the background commentary from the other seventh graders:
Student 1: How does he do that???
Student 2, in a bored tone: he’s gay, he can do anything 🙄
Moon. Fabric and thread. Stitched from a photo my brother took.