Is there a connection between lithium induced hypothyroidism and lithium efficacy in bipolar disorder?
Abstract Hypothyroidism, more commonly subclinical, appears a common abnormality, while the hypothalamic-pituitary-thyroid (HPT) axis abnormalities are quite common among patients with bipolar disorder. On the other hand, lithium has been used successfully in treating bipolar disorders, but lithium influence on the thyroid gland is one of the key side effects in the long-term therapy.