frontiers.health
Digital Therapeutics: the Keys to Succeed
%5Bvc_row+equal_height%3D%22yes%22%5D%5Bvc_column%5D%5Bvc_single_image+image%3D%224994%22+img_size%3D%22full%22+alignment%3D%22center%22%5D%5Bultimate_spacer+height%3D%2230%22+height_on_tabs%3D%2215%22+height_on_tabs_portrait%3D%2215%22+height_on_mob_landscape%3D%2215%22+height_on_mob%3D%2215%22%5D%5B%2Fvc_column%5D%5B%2Fvc_row%5D%5Bvc_row+css%3D%22.vc_custom_1561037856751%7Bpadding-top%3A+20px+%21important%3Bpadding-bottom%3A+20px+%21important%3B%7D%22%5D%5Bvc_column%5D%5Bvc_column_text+el_class%3D%22post-text%22%5D%0D%0A%3Ch3%3EThis+article+has+been+written+by+Aline+Noizet%2C+Frontiers+Health+Ambassador%3C%2Fh3%3E%0D%0ADigital+Therapeutics+%28DTx%29+have+been+under+the+spotlight+this+past+year.+They+have+the+potential+to+become+a+game+changer+in+healthcare+for+patients%2C+healthcare+professionals%2C+pharmaceuticals+and+insurance+companies.+The+%3Ca+href%3D%22https%3A%2F%2Fwww.dtxalliance.org%2F%22+target%3D%22_blank%22+rel%3D%22noopener+noreferrer%22%3EDigital+Therapeutics+Alliance%3C%2Fa%3E+developed+a+definition+to+differentiate+DTx+solutions+from+health+and+wellness+apps.%0D%0A%0D%0AThe+tipping+point+of+the+rise+of+DTx+was+%3Cstrong%3EPear+Therapeutics%3C%2Fstrong%3E+becoming+the+%3Cstrong%3Efirst+Prescription+Therapeutic+Solution%3C%2Fstrong%3E+to+receive+clearance+from+FDA+for+reSET+in+September+2017.+The+ReSET+Prescription+Digital+Therapeutic+%28PDT%29%2C+developed+in+collaboration+with+Sandoz%2C+treats+patients+with+Substance+Use+Disorder+%28SUD%29.+The+second+milestone+was+when+Pear+signed+a+collaboration+deal+with+Novartis+to+co-develop+digital+therapeutics+for+schizophrenia+and+multiple+sclerosis+in+March+2018.%0D%0A%0D%0A%3Cstrong%3EWhy+are+pharmaceuticals+looking+at+DTx%3F%3C%2Fstrong%3E%0D%0AThe+pharma+sector+has+been+undergoing+changes%2C+moving+towards+value-based+healthcare%2C+which+makes+a+nice+path+for+DTx+to+come+in%2C+complement+their+offerings+and+offer+a+good+differentiator+factor%3A+DTx+solutions+have+the+potential+to+%3Cstrong%3Ecollect+lots+of+real+world+data%3C%2Fstrong%3E+about+the+users+and+pharma+companies+could+use+those+data+to+improve+their+drugs%2C+adjust+therapy+pathways+and+come+up+with+new+treatments.%0D%0A%0D%0A%3Cem%3E%3Ca+href%3D%22https%3A%2F%2Fdthera.com%2F%22+target%3D%22_blank%22+rel%3D%22noopener+noreferrer%22%3EDthera+Sciences%3C%2Fa%3E+focus+on+neurodegenerative+solutions+such+as+Alzheimer%E2%80%99s%2C+delivering+digital+reminiscence+therapy%3C%2Fem%3E%0D%0A%0D%0APharmaceutical+companies+are+looking+for+%3Cstrong%3Esustainable+new+business+models%3C%2Fstrong%3E+to+complement+their+traditional+activities.+DTx+could+be+used+in+phase+II+of+clinical+trials+for+monitoring+patients%2C+helping+reduce+costs+of+drug+development+and+speeding+up+that+phase.+They+could+even+become+the+new+biosimilar.%0D%0A%0D%0ADTx+are+also+attractive+for+pharmaceuticals+because+they+have+the+potential+to+treat+diseases+with+no+or+limited+current+treatment%2C+like+IBS+%28Inflammatory+Bowel+Syndrome%29+and+to+address+better+comorbidities+with+a+unique+solution%3A+30%25+of+patients+with+migraine+also+suffer+from+IBS+for+instance.%0D%0A%0D%0A%3Cem%3E%3Ca+href%3D%22https%3A%2F%2Fwww.bold.health%2F%22+target%3D%22_blank%22+rel%3D%22noopener+noreferrer%22%3EBold+Health%3C%2Fa%3E+are+developing+digital+treatments+for+functional+and+autoimmune+condition+using+machine+learning+and+cognitive+behavior+therapies+%28CBT%29.%3C%2Fem%3E%0D%0A%0D%0A%3Cstrong%3EWhat+matters+are+the+outcomes%3C%2Fstrong%3E%0D%0AOutcome+should+be+the+goal+of+any+DTx+solution+regardless+of+the+intervention%2C+whether+it%E2%80%99s+digital+or+not.+Treatment+is+not+sufficient+anymore%3B+what+matters+are+the+outcomes.+Getting+to+know+the+patient+enables+better+treatment+options.+For+example%2C+the+patients+suffering+from+schizophrenia+are+more+comfortable+with+technology+than+with+people%2C+which+makes+DTx+solutions+more+efficient.+Digital+solutions+and+data+can+%3Cstrong%3Ehelp+patients+be+more+in+control+of+their+health+and+diseases%3C%2Fstrong%3E.%0D%0A%0D%0A%3Cem%3E%3Ca+href%3D%22https%3A%2F%2Fn1-headache.com%2F%22+target%3D%22_blank%22+rel%3D%22noopener+noreferrer%22%3ECurelator%3C%2Fa%3E+address+migraine+management+by+helping+each+individual+to+map+out+factors+affecting+or+improving+their+migraine+and+giving+them+CBT+tools+to+manage+the+attacks+and+avoid+medication+overuse.%3C%2Fem%3E%0D%0A%0D%0A%3Cem%3E%3Ca+href%3D%22https%3A%2F%2Funtire.me%2F%22+target%3D%22_blank%22+rel%3D%22noopener+noreferrer%22%3EUntire%3C%2Fa%3E+app+is+improving+cancer+patients+life+by+decreasing+fatigue+and+increasing+happiness.%3C%2Fem%3E%0D%0A%0D%0A%3Cstrong%3EEngagement+and+adoption%3C%2Fstrong%3E%0D%0A%0D%0A%3Cstrong%3E%E2%80%98The+blockbuster+drug+of+the+century+is+the+engaged+patient.%E2%80%99+%7E+Anand+Lyer%2C+WellDoc%3C%2Fstrong%3E%0D%0A%0D%0AIt%E2%80%99s+not+enough+to+develop+a+technologically+advanced+solution+if+the+patients+are+not+using+it.+It%E2%80%99s+essential+to+fully+understand+the+problem+that+needs+to+be+solved+and+to+focus+on+the+User+Experience+when+developing+the+solution%2C+as+it+is+key+to+make+the+solution+attractive%2C+keep+users+engaged+and+adherent+to+the+therapy.+Catering+for+cultural+differences+is+also+key+as+patients+in+different+countries+think+and+behave+differently.%0D%0A%0D%0A%3Cem%3E%3Ca+href%3D%22https%3A%2F%2Fwww.kaiahealth.com%2F%22+target%3D%22_blank%22+rel%3D%22noopener+noreferrer%22%3EKaia+Health%3C%2Fa%3E+develop+a+multimodal+back+pain+personalized+therapy+combining+physical%2C+psychological+and+educational+elements%2C+as+well+as+AI+and+motion+sensors+to+ensure+the+most+effective+therapy.+%27Kaia+listens.+Kaia+adapts%27.%3C%2Fem%3E%0D%0A%0D%0A%3Cem%3E%3Ca+href%3D%22http%3A%2F%2Fwww.sivan-innovation.com%2F%22+target%3D%22_blank%22+rel%3D%22noopener+noreferrer%22%3EMoovcare%3C%2Fa%3E+detect+relapse+or+complication+during+follow+up+of+lung+cancer+thanks+to+patients+sharing+their+symptoms+regularly+and+a+machine+learning+algorithm.+They+recently+got+reimbursement+authorisation+from+French+insurance+system.%3C%2Fem%3E%0D%0A%3Ch3%3EIf+you+are+interested+in+knowing+more+about+this+topic%2C+read+the+full+article+on+%3Ca+href%3D%22https%3A%2F%2Fwww.linkedin.com%2Fpulse%2Fdigital-therapeutics-keys-succeed-aline-noizet%2F%22+target%3D%22_blank%22+rel%3D%22noopener+noreferrer%22%3ELinkedIn+Pulse%3C%2Fa%3E.%3C%2Fh3%3E%0D%0A%5B%2Fvc_column_text%5D%5Bvc_cta+h2%3D%22Join+us+in+Berlin+next+Nov.+13-15%2C+2019%21%22+txt_align%3D%22center%22+add_button%3D%22bottom%22+btn_title%3D%22REGISTER%22+btn_align%3D%22center%22+btn_link%3D%22url%3Ahttps%253A%252F%252F2019.frontiershealth.co%252Fpage%252F1403925%252F%7C%7Ctarget%3A%2520_blank%7C%22%5D%5B%2Fvc_cta%5D%5B%2Fvc_column%5D%5B%2Fvc_row%5D%5Bvc_row+css%3D%22.vc_custom_1561037874898%7Bpadding-bottom%3A+20px+%21important%3B%7D%22%5D%5Bvc_column%5D%5Bvc_empty_space+height%3D%2245px%22%5D%5Bvc_custom_heading+text%3D%22MORE+STORIES%22+font_container%3D%22tag%3Ah1%7Ctext_align%3Acenter%7Ccolor%3A%2523de3014%22+use_theme_fonts%3D%22yes%22%5D%5Bcarousel_slide+id%3D%224048%22%5D%5Bvc_empty_space+height%3D%2245px%22%5D%5B%2Fvc_column%5D%5B%2Fvc_row%5D%5Bvc_row+full_width%3D%22stretch_row%22+bg_type%3D%22image%22+parallax_style%3D%22vcpb-default%22+bg_image_new%3D%22id%5E1916%7Curl%5Ehttp%3A%2F%2Ffh2019.stage.healthwareinternational.com%2Fwp-content%2Fuploads%2F2019%2F03%2Fbktg-frontiers-health-01.png%7Ccaption%5Enull%7Calt%5Enull%7Ctitle%5Ebktg+frontiers+health-01%7Cdescription%5Enull%22+bg_image_repeat%3D%22no-repeat%22+css%3D%22.vc_custom_1561456131965%7Bbackground-color%3A+%23000000+%21important%3B%7D%22%5D%5Bvc_column+width%3D%221%2F6%22%5D%5Bvc_empty_space+height%3D%2210px%22%5D%5B%2Fvc_column%5D%5Bvc_column+width%3D%222%2F3%22%5D%5Bvc_empty_space+height%3D%2245px%22%5D%5Bvc_single_image+image%3D%221120%22+img_size%3D%22medium%22+alignment%3D%22center%22%5D%5Bvc_empty_space+height%3D%2210px%22%5D%5Bvc_separator+color%3D%22white%22+border_width%3D%222%22+el_width%3D%2250%22%5D%5Bvc_empty_space+height%3D%2210px%22%5D%5Bvc_column_text+css%3D%22.vc_custom_1553793983115%7Bmargin-top%3A+15px+%21important%3Bmargin-right%3A+15px+%21important%3B%7D%22%5D%0D%0A%3Cp+style%3D%22text-align%3A+center%3B%22%3E%3Cspan+style%3D%22color%3A+%23fff%3B%22%3EIF+YOU+WOULD+LIKE+TO+TAKE+PART+IN+THE+EVENT%2C%0D%0AOR+BE+THE+FIRST+TO+FIND+OUT+ABOUT+OUR+2019+EDITION%0D%0A%3C%2Fspan%3E%5B%2Fvc_column_text%5D%5Bvc_btn+title%3D%22CONTACT+US%22+style%3D%22custom%22+custom_background%3D%22%23de3014%22+custom_text%3D%22%23ffffff%22+align%3D%22center%22+link%3D%22url%3Ahttps%253A%252F%252F2019.frontiershealth.co%252Fpage%252F1403926%252Fcontact-us%7C%7Ctarget%3A%2520_blank%7C%22+css%3D%22.vc_custom_1556782241429%7Bmargin-right%3A+15px+%21important%3Bborder-radius%3A+20px+%21important%3B%7D%22%5D%5Bvc_empty_space+height%3D%2245px%22%5D%5B%2Fvc_column%5D%5Bvc_column+width%3D%221%2F6%22%5D%5B%2Fvc_column%5D%5B%2Fvc_row%5D%3C%2Fp%3E