Chemical chaperone could open door to treatment of neurological disorder | The Source | Washington University in St. Louis
"Chemical chaperones" might be able to help a mutant protein (green) do its job of removing excess cholesterol (blue) from cells.An unexpected finding turned out to be a clue leading researchers at the School of Medicine to propose a new treatment approach for Niemann-Pick disease, a rare, deadly neurodegenerative disorder. To overcome the genetic defect in Niemann-Pick disease, the researchers suggest that chemical compounds could potentially "chaperone" mutant protein molecules through the cell's quality control machinery.