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The Protective Effects of Silymarin against Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity | | New Jersey Health Federation
The Protective Effects of Silymarin against Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity in Rats Aleksandar Rašković 1 , Nebojša Stilinović 1,* , Jovanka Kolarović 2 , Velibor Vasović 1 ,Saša Vukmirović 1 and Momir Mikov 1 1 Department of Pharmacology, Toxicology and Clinical Pharmacology, School of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia2 Department of Hematology and Oncology, Institute for Child and Youth Health Care of Vojvodina, Novi Sad, 21000 Novi Sad, Serbia * Author to whom correspondence should be addressed. Received: 7 September 2011 / Revised: 5 October 2011 / Accepted: 10 October 2011 / Published: 12 October 2011 Download PDF [515 KB, uploaded 18 June 2014] Abstract Silymarin is a complex of five major compounds, and silibinin is the most biologically active component of the complex. The aim of this study was to investigate, evaluate and confirm the potential cardioprotective and hepatoprotective effects of administration of