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Homeopathy: yet another systematic review fails to prove its effectiveness
The indefatigable Robert Mathie has published another systematic review/meta-analysis, and yet again he failed to come up with a convincingly positive result. This new paper reviews randomised controlled trials (RCTs) of individualised homeopathic treatment (IHT) in which the control (comparator) group was other than placebo (OTP). Its stated aim was to determine the comparative effectiveness of IHT on health-related outcomes in adults and children for any clinical condition that has been the subject of at least one OTP-controlled trial. For each eligible trial, published in the peer-reviewed literature up to the end of 2015, the authors assessed its risk of bias (internal validity) using the Cochrane tool, and its relative pragmatic or explanatory attitude (external validity) using the 10-domain PRECIS tool. All RCTs were categorised according to whether they examined IHT as an alternative treatment (study design Ia), adjunctively with another intervention (design Ib), or compared