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The brain's gateway | Neuro-patch
There have been a few papers lately on the function of the thalamic reticular nucleus (TRN) that characterize it as a filter, a sieve, and a switchboard. The citations and abstracts of 4 of these papers are below. Francis Crick suggested this function for the TRN many years ago but it was not possible until recently to demonstrate it because of the anatomy of the TRN. The thalamus sits at the center of the brain and is connected to the brain stem and spinal cord below, the cerebral hemispheres above and the basal ganglia to the sides. The thalamus is part of almost all the functional processing loops in the brain. In particular, almost all sensory information enters the cortex from the thalamus, and every corner of the cortex sends signals back to the thalamus. When this traffic, the thalamo-cerebral loops, shut down, so does consciousness. The TRN is a thin layer of neurons that almost entirely covers the thalamus. Because it is so thin and so deep in the brain, it has been difficult