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Divergent effects of vascular endothelial growth factor, VEGF and the N-terminal fragment of the parathormone-related protein, PTHrP on human adipose derived from mesenchymal stem cells - Revista de Osteoporosis y Metabolismo Mineral · Publicación Oficial SEIOMM
The possibility of obtaining stem cells from adult tissues is highly attractive as they can potentially generate a variety of differentiated cells and be used in tissue regeneration. The study of stem cells obtained from adult organisms began some 50 years ago, when hematopoietic stem cells were described, which give rise to all blood cells1. Later, researchers described mesenchymal lineage stem cells and differentiated them into adipocyte, osteoblastic and chondrocytic cells. Mesenchymal stem cells were originally discovered in bone marrow, but were later found in other adult tissues, including peripheral adipose tissue. As Bravo et al.2 report in their study, mesenchymal cells are characterized by the expression of surface markers, including CD90, and the use of others, such as CD45 and CD34.