Hematological Profile in Schistosoma mansoni Infected Mice Treated with Commiphora molmol Extract Compared with Praziquantel | PSM | Nonprofit Scientific Publishing
Abstract: As Schistosoma mansoni worms inhabit the portal triad of infected hosts, deleterious changes were encountered in the blood picture. The aim of the study is to explore the damaging hematological effects due to S.mansoni infection in albino mice before and after treatment with either Commiphora molmol extract or Praziquantel. Seventy two albino mice were recruited in this study and divided into 4 groups of 18 mice each, 54 of them were infected with S.mansoni cercariae.7 weeks post-infection, infected animals were treated with 500 mg/kg either as a single dose for 2 days in Praziquantel or for 5 consecutive days in Commiphora molmol extract. Blood samples were collected at 1, 2 and 4 weeks after treatment for assessment of complete blood counts (Hb, erythrocytes count, haematocrite value, MCV, MCH, MCHC, Platelet count, leucocytic count and differential leucocytic counts).S.mansoni infection resulted in multiple damaging effects of the blood profile on infected non-treated