white matter fibers


Human Connectome Project white matter fibers, via diffusion spectral imaging.

we had a neurosurgeon come in to talk to us about the brain. my take on neurosurgeons as lecturers is that they either are absolutely, irrefutably, incontrovertibly AWESOME-I-think-I-just-fell-in-love-please-marry-me-also-I-have-crippling-debt, or they are as dry as the purported wit I am known to shit out on a daily basis. or is it just the shit? either way is not completely true, actually, because my wit is hiLARious. and these neurosurg lecturers are very not. 

they do afford me the great opportunity to craft this skill I’ve been working on, which is falling asleep with my eyes wide open. hasn’t been working so well. although I HAVE managed to smoothly execute a ‘nodding off and violently pitching forward to oh-HAY-I’m-just-checking-my-shoelace/scratching my foot/adjusting my flats' manoeuvre.

fucking beautiful. 

as are these brain images (see what I did there? brought the post back 'round full-circle. genius). my alpha-waves-eyes-wide-open state was briefly interrupted when these babies appeared on our ridiculously large lecture screen. granted, resolution is kind of iffy, and there are things that definitely don’t belong in places that may or may not exist, but sooo puuurteh. and so many colours!

SCIENCE. making the world a more beautiful place, one tenuous-fibre-tract-imaging-study at a time. 

Aerobic Exercise Preserves Brain Volume and Improves Cognitive Function

Using a new MRI technique, researchers found that adults with mild cognitive impairment (MCI) who exercised four times a week over a six-month period experienced an increase in brain volume in specific, or local, areas of the brain, but adults who participated in aerobic exercise experienced greater gains than those who just stretched. The study was presented at the annual meeting of the Radiological Society of North America (RSNA).

“Even over a short period of time, we saw aerobic exercise lead to a remarkable change in the brain,” said the study’s lead investigator, Laura D. Baker, Ph.D., from Wake Forest School of Medicine (WFSM) in Winston-Salem, N.C.

The study included 35 adults with MCI participating in a randomized, controlled trial of exercise intervention. Individuals with MCI are at risk of developing Alzheimer’s disease (AD), the most common form of dementia, which affects more than 5 million Americans today.

The participants were divided into two groups. Sixteen adults (average age 63 years) engaged in aerobic activity, including treadmill, stationary bike or elliptical training, four times per week for six months. A control group of 19 adults (average age 67 years) participated in stretching exercises with the same frequency. High-resolution brain MR images were acquired from all participants before and after the six-month activity period. The MRI results were compared using conventional and biomechanical metrics to measure the change in both brain volume and shape.

“We used high-resolution MR images to measure anatomical changes within areas of the brain to obtain both volumetric data and directional information,” said Jeongchul Kim, Ph.D., co-investigator on the study from WFSM.  

The analysis revealed that for both the aerobic and stretching groups, brain volume increased in most gray matter regions, including the temporal lobe, which supports short-term memory.  

“Compared to the stretching group, the aerobic activity group had greater preservation of total brain volume, increased local gray matter volume and increased directional stretch of brain tissue,” Dr. Kim said.  

Among participants of the stretching group, the analysis revealed a local contraction, or atrophy, within the white matter connecting fibers. According to Dr. Kim, such directional deformation, or shape change, is partially related to volume loss, but not always.

“Directional changes in the brain without local volume changes could be a novel biomarker for neurological disease,” he said. “It may be a more sensitive marker for the tiny changes that occur in a specific brain region before volumetric changes are detectable on MRI.”

He said both MRI measures are important to the treatment of MCI and AD, which require the careful tracking of changes in the brain while patients engage in interventions including diet and exercise to slow the progression of the disease.

Study participants were tested to determine the effect of exercise intervention on cognitive performance. Participants in the aerobic exercise group showed statistically significant improvement in executive function after six months, whereas the stretching group did not improve.

“Any type of exercise can be beneficial,” Dr. Kim said. “If possible, aerobic activity may create potential benefits for higher cognitive functioning.”

Experts say alcohol-related brain damage is underdiagnosed and often confused with Alzheimer’s disease, other forms of dementia or just getting older. Now, brain imaging is revealing how long-term alcohol abuse can change the structure of the brain, shrinking gray-matter cells in areas that govern learning, memory, decision-making and social behavior, as well as damaging white-matter fibers that connect one part of the brain with others.