Alkohol lässt dich vergessen.
Xannax nimmt dir die Angst.
Speed hält dich wach.
Kokain gibt dir Klarheit.
Nikotin bringt dir Antrieb.
Cannabis lässt dich zur Ruhe kommen.
Valium sorgt für deinen Schlaf.
LSD öffnet deine Augen.
Hydromorphon nimmt deine Schmerzen.
MDMA verspricht dir ‘du kannst tanzen’.
Ketamin verzerrt Zeit und Raum.
Heroin gibt dir Geborgenheit.
Pilze lassen dich verstehen ‘wieso’.
Tilidin bringt dich in Einklang.
Oxycodon spendet dir Wärme.
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Du hast die Wahl.

Molecule of the Day: Diazepam/Valium

Diazepam (C16H13ClN2O), also known as Valium, is a white solid that is of significant pharmaceutical importance. It is a member of the benzodiazepine family, which shares the similar bicyclic system comprising of a conjoined benzene and diazepine ring.

Diazepam is used to treat anxiety and panic disorders, and this is achieved by its binding to GABA receptors on neurons. This causes the active site of the receptors to become a better fit for GABA molecules, resulting in a higher binding of GABA to it. This triggers a greater influx of chloride ions into the neuron. 

Since the intracellular portion of the neuron is more negative than normal, the membrane is hyperpolarised to a greater extent. Consequently, a stronger stimulus is needed to trigger an action potential, which is created when a stimulus causes the membrane to reach the threshold potential.

Since the resting potential is now more negative, the action potential and thus firing of the neuron is less likely. This then produces the anxiolytic, sedative, amnesia-inducing, and anticonvulsant effects of diazepam. 

Diazepam can be produced by various synthetic pathways; one such route is shown below.

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