types of dementia

think of the grunkle calendar like a zine, but with 12 pictures themed around months! it’s only $10 and all the proceeds go to the lewy body dementia association, i had to look up what that was but lewy body dementia is the second most common type of dementia after alzheimer’s disease, so its a good cause!

and look at all these great artists including me lol

ALSO if you’re worried about trying to explain a “sexy” calendar for 2 cartoon old men, it’s totally safe for work!! there’s no shipping, nothing explicit, i can’t guarantee that you wont find a shirtless grunk in there because i dont know what everyone drew but i can guarantee pants. if that guarantee isn’t good enough then hey, tuck it away and just treat it like a big, weirdly formatted zine with days and weeks on half of it

buy it here! without enough preorders it can’t get printed so go on!

The cognitive and sensory impairments associated with Alzheimer’s and other types of dementia often result in difficulty eating. 

Eatwell bowls are designed with slanted bottoms that help food collect to one side for easy scooping. The interior of the dining ware is also bright blue in color, an uncommon hue for food which helps users with dementia identify food in their bowls with ease. Spoons are intentionally designed to hug the side of the dinnerware, making collecting food easier and preventing spillage. Handles for drinking cups and utensils are made to allow for easy gripping and stability.

The result of all these intentional elements working together is a dining set that has been found to allow users with dementia to consume 24% more food and 84% more liquid.

Learn more about this Eatwell set here.

What are the differences between the types of dementia?

Image is also in my book, When Someone You Know is Living in a Dementia Care Community, by JHU Press.

Depending on who you ask, there are over seventy—or over 100—types of dementia. It’s really confusing, but dementia is just an umbrella term for a group of diseases related to cognitive loss over time. For example, the most common type of dementia is Alzheimer’s disease.


  • The big symptom is memory loss
  • There are two types of Alzheimer’s: early-onset and later-onset
  • Early-onset AD is familial, which means that you are significantly more likely to get it if a first-degree relative has it
  • AD can last up to 15 years

Vascular Dementia

  • The big symptom is trouble with gait/spatial awareness
  • Vascular dementia can be brought on by strokes, cardiovascular issues
  • People with Vascular Dementia do not always have memory problems, especially not in the beginning

Dementia with Lewy Bodies

  • The big symptoms are hallucinations and fluctuating impairment
  • Lewy Body Diseases is actually its own group of diseases, which includes Dementia with Lewy Bodies, Parkinson’s Disease, and Parkinson’s Disease Dementia

Fronto-temporal Lobar Dementia (FTD)

  • There are a few types of FTD, so the symptoms vary between things like: speech impairments, movement-related issues, and behavioral issues 
  • FTD can be diagnosed earlier than most dementias: sometimes it is found in people between the ages of 40 and 60.


Stiles was sitting on the hospital bed, having just gotten back from taking a few tests. He had collapsed at home and his dad found him laying there hours later after returning from work. He knew they were whispering behind his back and it was irritating him. Though he could tell they were testing for the same type of dementia that his mother had, the one that had killed her.

It didn’t help that he was still a little agitated from his fight with Lexi the day before. He wanted her to be with him now but doubted that she would show up. He looked down at his thumbs and bit his lip.

Scientists Keep a Molecule from Moving Inside Nerve Cells to Prevent Cell Death

Amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease) is a progressive disorder that devastates motor nerve cells. People diagnosed with ALS slowly lose the ability to control muscle movement, and are ultimately unable to speak, eat, move, or breathe. The cellular mechanisms behind ALS are also found in certain types of dementia.

A groundbreaking scientific study published in Nature Medicine has found one way an RNA binding protein may contribute to ALS disease progression. Cells make RNA to carry instructions for making proteins from DNA to protein-constructing machinery.

The culprit protein, TDP-43, normally binds to small pieces of newly read RNA and helps shuttle the fragments around inside nerve cell nuclei. The study describes for the first time the molecular consequences of misplaced TDP-43 inside nerve cells, and demonstrates that correcting its location can restore nerve cell function. Misplacement of TDP-43 in nerve cells is a hallmark of ALS and other neurological disorders including frontotemporal dementia (FTD), Alzheimer’s, Parkinson’s, and Huntington’s diseases. Studies that characterize common mechanisms behind these diseases could have widespread implications and may also accelerate development of broad-based therapies.

To find the misplaced TDP-43, the researchers viewed nerve cells donated by people who died from ALS or FTD under high powered microscopes. They discovered TDP-43 accumulates in nerve cell mitochondria, critical structures responsible for generating the enormous amount of energy nerve cells require. By physically isolating the affected mitochondria the researchers were able to pinpoint TDP-43’s exact location inside the subcellular structures. They were also able to characterize variations of the protein most likely to get misplaced.

This important work was led by Xinglong Wang, PhD, from the department of pathology at Case Western Reserve University School of Medicine and a team of scientists from his laboratory.

“By multiple approaches, we have identified the mitochondrial inner membrane facing matrix as the major site for mitochondrial TDP-43,” explained Wang. “Mitochondria might be major accumulation sites of TDP-43 in dying neurons in various major neurodegenerative diseases.”

The researchers discovered that once inside the mitochondria, TDP-43 resumes its RNA binding role and attaches itself to mitochondrial genetic material. This disrupts the mitochondria’s ability to generate energy for the cell. Wang’s team was able to precisely identify the RNA in mitochondria that was bound by TDP-43 and observe the resultant disassembly of mitochondrial protein complexes. This finding provides much needed clarity on the consequences of TDP-43 misplacement inside nerve cells and opens the door for deeper studies involving a range of neurological disorders. Although the study focused on ALS and FTD, according to Wang “mislocalization of TDP-43 represents a key pathological feature correlating strongly with symptoms in more than half of Alzheimer’s disease patients.”

Mutations in the gene encoding TDP-43 have long been linked to neurodegenerative diseases like ALS and FTD. Wang’s team found that disease-associated mutations in TDP-43 enhance its misplacement inside nerve cells. The researchers also identified sections of TDP-43 that are recognized by mitochondria and serve as signals to let it inside. These sections could serve as therapeutic targets, as the study found blocking them prevents TDP-43 from localizing inside mitochondria. Importantly, Wang’s team was able to keep TDP-43 out of nerve cell mitochondria in mice using small proteins which “almost completely” prevented nerve cell toxicity and disease progression.

“We, for the first time, provide the novel concept that the inhibition of TDP-43 mitochondrial localization is sufficient to prevent TDP-43-linked neurodegeneration,” said Wang. “Targeting mitochondrial TDP-43 could be a novel therapeutic approach for ALS, FTD and other TDP-43-linked neurodegenerative diseases.”

Wang has begun to develop small proteins that prevent TDP-43 from reaching mitochondria in human nerve cells, and has a patent pending for the therapeutic molecule used in the study.

There is no treatment currently available for ALS or FTD. The average life expectancy for people newly diagnosed with ALS is just three years, according to The ALS Association.

Just a thought

Dr Palmer clearly had Alzheimer’s and it was theorized after he was introduced that he was Wren’s father. For anyone who never read those theories and never thought of that connection it was based on the fact that they are both British and that Wren told Hanna his dad was in a place much like Radley. He explained to her what an ambiguous loss is and used a relative slipping into dementia as an example of it. Since Alzheimer’s is a type of dementia he could have been referring to his dad having it. It would also make sense given that kids tend to follow in their parents footsteps so if his dad was a doctor he would be more likely to be one himself. Now for the real reason of this post. I’m watching Run Ali Run which is A’s first episode back in season 5. Spencer went to Radley to see Eddie Lamb and when she got there Detective Tanner was there so she sat in a seat and covered her face with a magazine. I found the front page headline interesting. The magazine they decided to use for this scene happens to say “An end to Alzheimer’s” on the front of it along with “finding a key disease gene has triggered a race for the cure.” I find it interesting that they would use that magazine given how many people suspect Wren as A and the connection made to Dr Palmer. I’m not saying it’s a clue, I just find it interesting.