Cassandra: She’s an agent for the NCR’s president, and commonly wields an assault carbine. She’s also more than capable of using a machete or a sword if in close-quarters combat.
Iron Bull: While he acts as the boss of a mercenary company, he’s actually spying for the Brotherhood of Steel. He’s grown fond of his group of misfits, and starts having doubts about the Brotherhood’s morals and mission. He carries around a super sledge and a Fat Man and just LOVES beating people with the super sledge.
Blackwall: He’s a mercenary that has wandered all over post-war America. He was, once, a soldier for the NCR, but left over reasons he won’t disclose.
Sera: She’s a thief in New California Republic (the city that’s the capital of the NCR) and picks on the politicians on a regular basis. She carries around a sniper rifle, and she’s adept at sniping and hacking computers and robots.
Varric: He’s a writer who lives in the Atomic Wrangler permanently, and he’s an investor in several of the casinos. He’s eternally curious about what’s going on in the Lucky 38, and hounds the Courier for details. He carries around a tricked-out sniper rifle he’s fondly named Bianca.
Cole: No one’s quite sure what he is, but he pops up as often and as mysteriously as the Mysterious Stranger, helping those in need at chance and then disappearing just as quickly. Some say he’s a ghost, some say he’s a ghoul, but no one knows the truth.
Dorian: He was born and raised in the Institute, but left over differences with their morals, so he settles in Diamond City. He ignores the suspicious whispers, and continues to study his field of science. He uses a quick-shot laser gun, and prefers energy weapons.
Vivienne: She’s a politician in the NCR, and one of the most shrewd senators. Rumor has it that she’s gunning for the presidency. Her preference is for plasma weapons.
Solas: He comes out of a vault, fully intact and not a ghoul, after being inside for 200 years. He refuses to talk about what happened in the vault or why he’s still alive, but he’s left appalled by the state of Earth following the Great War. He begins his own crusade to “restore” it. He’s an adept user of energy weapons.
Josephine: She’s an NCR ambassador, and does her best to smooth relationships over with whoever she handles. She’s very good at her job, and comes from an old family that’s been involved in the NCR from its birth. She does not like to fight, and balks at even holding a pistol.
Leliana: Like Cassandra, she also works for the NCR, and is the best spy they have. She is fond of Pre-War music, and has learned how to play a bunch of old instruments, which she tries her best to preserve. She prefers the use of a silenced 10-mm pistol when working, but if she can fight at a distance, she’ll use a sniper rifle.
Cullen: He’s a commander in the NCR’s army. He prefers shotguns or carbines in combat.
Aveline: She’s an NCR cop that gets sent to Freeside to try to maintain the peace; Wesley dies on the way. Within a few years of her work, Freeside is actually somewhat less shit than it was before. She prefers assault rifles.
Fenris: He’s an escaped synth from the Institute, and hates it and its scientists with a burning passion. He will kill any coursers that are sent after him, and aids other escaped synths to freedom.
Carver: He comes from a family in the NCR, and eventually moves to New Vegas with his sister, older sibling, and mother. He constantly feels as though he’s overshadowed by his big sibling, who gets much attention as a top-notch mercenary.
Bethany: She comes from a family in the NCR, and eventually moves to New Vegas with her brother, older sibling, and mother. She doesn’t care much for New Vegas, and is very private person, but an effective user of energy weapons.
Anders: He is a psyker with very blatant abilities, and it has led him to be shamed in society, so he has taken to protesting for acceptance and rights. He is also an experienced doctor and is good at using energy weapons and explosives, namely grenades and C4 explosives.
Merrill: She’s from a tribe in the Midwest, albeit one she finds herself kicked out of due to her interests in old world technology. She primarily uses energy weapons.
Isabela: She’s a smuggler of illicit goods such as chems across the NCR border. She hails from the Great Khans, originally, but seems to have little interest in it and speaks hardly at all about her past. She’s exceptionally good at sneaking and stabbing people while using a stealth boy.
Sebastian: He hails from New Canaan, and lived there until it was sacked. He survives and seeks out revenge against the White Legs. After that, he takes to New Vegas for a time, hoping to spread his beliefs there.
Alistair: Rumor has it that he’s the illegitimate child of a former NCR president, but he doesn’t seem to talk much about it. He was originally pegged to work for the NCR’s army, but he had a sharp lack of interest in it. Alistair is experienced with rifles.
Sten: A straight-laced member of the Brotherhood of Steel, he abides by the Codex firmly. He eventually becomes the Elder of a chapter of the Brotherhood.
Shale: She’s a super mutant from the Master’s army, a particularly stoic nightkin who resides in Jamestown. She prefers using a super sledge, and has little patience for others, even other super mutants.
Oghren: He’s from a vault, and he was assigned guard work until he got into a fight, following his wife’s disappearance into the depths of the unexplored parts of the vault. Like several of the others, he prefers a super sledge.
Dog: A good and loyal dog. Unproblematic fave.
Zevran: He’s an assassin from the Talon Merc Company, having been sold to them at a young age. He botches a mission on purpose and ditches them. He’s an excellent infiltrator, capable of picking any lock or hacking any computer, and is never without a stealth boy.
Wynne: a member of Maud’s Muggers Wynne hails from the Capital Wasteland, and is an experienced doctor. She may or may not be a psyker, and had a near-death experience during the Enclave’s attacks, which she miraculously survived. She knows her way around energy weapons.
Morrigan: She hails, originally, from deep in the swamps of Point Lookout. She was raised away from most of civilization with a mysterious old woman who is a psyker, and she’s one, too. She eventually ventures out into the wastes, and is proficient with energy weapons and poison.