Transdermals: Cross Between Edibles and Topicals... Sorta
Okay, here’s one that many of you may not have heard of yet: transdermals. And yes, that’s different from a topical and here’s how. Topicals are great for relatively surface, localized pain that is mainly caused by inflammation (arthritis, a pulled muscle, a bad back, etc.). Transdermals are much more universal. There are, like topicals, applied directly to the skin. The difference is that there is a compound in transdermals that allow the cannabinoids to pass the blood brain barrier, get into the blood stream, activate, and spread through your whole body. Because they activate and circulate, they do get you high (if they contain THC).
Right now, the company Mary’s Medicinals is the leader in transdermal products. They have patches that work in a similar manner to a nicotine patch and gels that are more like lotions. These products come in a variety of cannabinoids, most of which will probably sound pretty foreign to you if you’re not familiar with cannabinoids other than THC, so here’s a basic rundown.
THC Indica: THC is psychoactive, so this product will make you feel high. Indicas, as discussed in a previous post, make you feel sleepy, relaxed, and happy. These patches are great for night time use, especially if you are suffering from chronic pain, seizures in your sleep, insomnia, restless leg syndrome, or just want a really good night’s sleep. I used about ¼ of one of these patches on a plane one time. Before this, I had been prescribed Klonopin for flying, which I usually washed down with two glasses of red wine. With this cocktail, I was usually able to sleep for about 10-20 minutes at a time on planes. When I used the patch, however, I was asleep for the full 3 ½ hour plane ride from Denver to Philadelphia. I have never had such an easy flight!
THC Sativa: THC is psychoactive, so this product will make you feel high. Sativas produce more of the head high, and are more energetic so this would be ideal for daytime use. It is especially beneficial to those dealing with ADD/ADHD as it can feel similar to adderall, but without making the user feel strung out or not like themselves. It’s, also, great for those who suffer from migraines. Because these patches are extended release, they can last up to 12 hours which is much longer than smoking. However, if you feel a migraine coming on, inhalation is going to be the fastest way to get relief, as you feel that within about 5 minutes. Transdermals can take 20-60 minutes to activate.
THC Hybrid: THC is psychoactive, so this product will make you feel high. This is going to be a well balanced high between body and head. It generally feels a little floaty, but very functional. This is generally used to battle nausea, anxiety, and pain during the daytime. It won’t be you sleepy the way an indica can be, but it won’t be overly stimulating the way a sativa can feel.
CBD:THC: THC is psychoactive, so this product will make you feel high, but CBD tends to counteract the psychoactive properties of THC, so the high will be very mild. It’ll more feel like you’ve taken the edge off rather than really feeling high. In terms of medical benefits, CBD works best when it’s used with THC. They basically have a symbiotic relationship where they enhance the effects of one another. CBD helps to increase circulation, take down inflammation, regulate bodily systems such as blood sugar and hormone levels, stop muscular and other kinds of spasms, decrease anxiety, and even fight cancer. THC also helps decrease anxiety, fight nausea, and lessen any physical pain.
CBD: CBD is non-psychoactive, so you will not feel high from this product. I do recommend the 1:1 ratio patch discussed above, but if you don’t want to feel high at all, or have a pass drug screenings, then this patch might be a better choice for you. It does all of the things mentioned above under CBD (increase circulation, take down inflammation, regulate bodily systems such as blood sugar and hormone levels, stop muscular and other kinds of spasms, decrease anxiety, and even fight cancer). So if you have a bad back, knee, hip, are suffering from crohn’s disease, parkinson’s, MS, fibromyalgia, seizures, arthritis, or just went too hard at the gym the day before, you will feel better for using this patch, but it won’t affect your headspace at all.
THCa: THCa is non-psychoactive, so you will not feel high from this product. It’s very similar to CBD in what it treats, especially pains caused by inflammation. Because they’re not very different, I recommend that you try each one and see which one works better for you.
CBN: CBN is mostly non-psychoactive, so you will not really feel high from this product, but you will feel a little stoney and groggy. CBN is the oxidized form of THC and retains about 10% of its psychoactive properties, which creates the groggy feeling. It is mainly recommended for those who suffer from insomnia, as it is great for sleep. It, also, has a mild anti-bacterial/anti-viral property, so it boosts your immune system to fight off infections.
These patches can be cut into smaller pieces; you don’t have to use a whole patch at once. You can, also, mix and match patches. The last time I went to get a tattoo done, I used half a CBN patch and half of a CBD:THC patch. The CBD:THC patch took down my pain level, and the CBN patch helped me relax and settle into my 3 hour session. They are extended release, so you should start to feel effects after about 20-30 minutes, and full effects after an hour. Typically the patches last for 8-12 hours. You will notice that the mg level on the patches is much lower than on edibles. This is because transdermals bypass the liver, which filters out a lot of THC. Because you’re losing this filtration process, more of the THC and other cannabinoids will pass into your bloodstream with transdermals than with edibles, so they can make them less potent, but they still feel just as strong. What’s really nice about these is that, if after a few hours or so you don’t like the effect of the patch, you can remove it and the effect will stop pretty quickly. If you’ve ever eaten too much of an edible and had no choice but to ride it out, you know how great this option can be!
These patches work best if you apply them, not right where the pain is, but on thin skin in proximity to the pain. You want to get the cannabinoids into your bloodstream as quickly as possible so that they can start working, so it’s best to apply them to places like the tops of the feet, the inside of the wrists or hips, or behind the ears. If you have chronic headaches, behind the ears or on the back of the neck would be best as that’s where you have thin skin, but it’s close to the pain. If you have back pain, apply the patches to the inside of the hips for proximity, etc. I do recommend that you apply even amounts to either side of the body for the best results.
The gel is a little bit different in how you apply it, but no different in effects. The gel pen either twists or clicks at one end, and squirts out 2mg of gel. You still want to apply it to places where the skin in thin, but you do have more options as you won’t be wearing a patch all day. For example, if you have a headache, you can pally the gel directly to your temples. The gel will activate in about 20-60 minutes, just like the patches, but the patches are extended release and the gels aren’t, so the gel will likely wear off after about 4-5 hours. Luckily, it’s physically impossible to use too much of this stuff, so reapply as necessary.
Transdermals can be a great way of medicating if you don’t want to smoke, or want longer lasting relief without having to eat something. I can imagine that if you’re going through chemo, you might not want to eat a whole brownie to get your medicine, and this is a wonderful alternative. It’s discrete, odorless, and long lasting. You may be thinking that there’s no way you could get high from a patch, but I say don’t knock it til you’ve tried it!
“Influential body modification artist Steve Haworth is credited with inventing the transdermal implant, with the first instance being installed in 1996 as Joe Aylward’s famous “Metal Mohawk”. Four years later, Samppa Von Cyborg began implanting transdermals using posts of his own design. While these procedures were largely successful, the designs left much room for improvement. It is Samppa’s philosophy that even if something works reasonably well, it is crucial to keep researching, reassessing, and redeveloping designs and procedures in order to push body modification innovation forward and always strive strive for better results.”
New silicone and transdermals in stock! First come, first served as usual. Silicone from the awesome @steve_haworth and transdermals from the magnificent @samppavoncyborg! For better pictures visit our blog at www.calmbodymod.com/blog. #calmbodymod #calmbodymodification #bodymod #bodymodification #bodyaltering #stockholm #sweden #sodermalm #hornsgatan #mybodymod #silicone #transdermals #triforce (på/i CALM Bodymodification)
E insomma ogni tanto mi tornava in mente che Gene Ween aveva salutato la compagnia e m’intristivo, poi scopro tardissimissivamente che c’è reunion in corso e mi pare doveroso festeggiare con questa meravigliosa canzoncyna.
Poi uno dice: ma come? da uno degli ultimi dischi? ma al massimo da The Mollusk. L’hipsterometro segna poseur. E invece no, non capite una cippa, Transdermal Celebration è una figata il video pure, che fra l'altro l’ha fatto un fan, e ai ween è piaciuto e l’hanno adottato come video ufficiale. Ci ha messo solo dieci anni a metterlo su youtube in HD e io altri tre ad accorgermene ma fa niente.
Another way to administer sumatriptan (Imitrex) was just approved by the FDA
Sumatriptan is now available in a nasal powder form. We already have sumatriptan in a tablet, injection, nasal spray, and a skin patch. I mentioned this product over 5 years ago and finally it was just approved by the FDA. This does not mean it will be available right away as it often takes many months for the company to ramp up production. In some cases, such as with inhaled migraine drug Semprana (formerly called Levadex), it takes years before the manufacturer achieves FDA quality standards of production.
OptiNose is the company that developed Xsail Breath Powered Delivery Device which is used to deliver sumatriptan nasal powder. OptiNose licensed the product to Avanir Pharmaceuticals and they named it Onzetra. Onzetra is a fast-acting dry powder that is delivered into the nasal cavity. The patient exhales into the device, which seals the nasal cavity, and this carries the medication from the device directly into one side of the nose.
Nasal powder should be much more effective and more consistently effective than the nasal spray. The problem with the nasal spray is that the liquid tends to leak out of the nose or into the mouth, while the powder sticks to the nasal mucosa and all of it gets absorbed. And while the nasal spray contains 20 mg of sumatriptan and Onzetra only 11 mg, Onzetra should be more effective. Similarly, only 6 mg of injected sumatriptan is much more effective than 100 mg of sumatriptan in a tablet. But do we need another form of sumatriptan? Actually this may be a very good product for people who have a sudden onset of a severe migraine or those who vomit with their attacks. The injection works well for these patients, but many would rather avoid the pain of a shot. Zecuity, a new transdermal form of sumatriptan would seem to be a good choice, except for the fact that it works much slower than Onzentra.
The approval of Onzetra Xsal was based on the data from Phase 2 and 3 clinical trials, safety data from over 300 patients, and the historical data from various other formulations of sumatriptan, which have been on the market for over 20 years. One of the studies showed a significantly greater proportion of Onzetra Xsail patients reported headache relief at 30 minutes (42% vs. 27%) and at every time point up to 2 hours post-dose vs. placebo patients (68% vs. 45%).
Onzetra Xsail will be supplied as a disposable nosepiece containing a capsule and a reusable device. Each capsule contains 11 mg of sumatriptan and each kit contains 8 doses.
What if… Millions of people in Gaza and Israel ate LSD? Would they stop killing each other? History shows that people lose interest in murder after having the Psychedelic Experience… What if… Billions took a trip? Would we have Global Peace? http://vandergreg.blogspot.com/search?q=mkultra
KH: AWESOME Idea Greg….you are absolutly right…seriously. Cia did experiments on troops in the 60s….they could “crop dust” the whole Gaza area with some good ol’ Owsley!
Greg Vanderlaan MKULTRA
KH: MKULTRA? KH: Acid is transdermal KH: Hey Greg….we finally agree on something…n no response? LOL
AS: Lol let’s do it!
KH: I seriously have access to a crop duster plane…. =0)
KH: Wether it’s up to a trans atlantic flight…..well! LOLOL
AS: No fly zones dude. Best to go aerosol
KH: What? Put the shit inna can? Would take to long! Go with a Owsley bomb than….F-16 fly over n BAM! LOL
KH: Greg….see the conumbdrum you’ve started!LOL
KH: Fuck “No fly zones”. We’re the USA!
AS: Hot air balloons launched from Cyprus when the winds are bowing ese
Project MKUltra — sometimes referred to as the CIA’s mind control program — is the code name of a U.S. government human research operation experimenting in the behavioral engineering of humans.
CO: Not really. It all highly depends on your personality. Sometimes I feel like a predator while tripping in the woods at night. I don’t think it’s a good idea to take everything human from those people. That could backfire really bad.
Liberia was the best example. A huge mix made out of different psychedelics, weed and cocaine turned those people into naked cannibals with machetes.
Even stuff like DMT could go wrong. People who are that religious will use that experience to get even more fanatic. I mean that’s how every religion was made in the first place.
KH: Greg….I wouldn’t trust Wikipedia for information on how to boil water!
Greg Vanderlaan: Seriously, one of the subjects studied in the CIA project MKULTRA was how to use LSD during war… for example: What if the “Enemy” took a trip… would they lose all interest in war? Would they become guitar players and poets?
Greg Vanderlaan: How could anything backfire worse than what it is now? Those people over there have been killing each other for thousands of years with no end in sight… Why not try something different?
CO: I know. I have the dox on my drive. Wait I will upload it.
Greg Vanderlaan: http://vandergreg.blogspot.com/search?q=mkultra The project conducted tests on college students at Stanford University. Ken Kesey and Robert Hunter both volunteered to eat LSD and other mind control drugs and report on the effects. Later, Ken started having “ACID TEST” parties where the participants took LSD and danced to the Music of the Grateful Dead. Robert Hunter wrote lyrics for the Dead.
Just co-incidence? or were “the sixties” a CIA experiment to see what happens?
KH: N…Those bad trips…or violent trips are one in a million.
KH: Silly Syben Mushrooms……those things just make you giggle n grin.
SM: Greg, the fighting will continue. Hamas, regardless of what they say, will continue to kill their women and children by storing weapons and rockets in schools and hospitals. Have they bitten off more than they can handle? Way in over their head. Obama And Scary Kerry really supporting Hamas.
SL: If you were to give LSD to a soldier who was just “serving his time” and doing his job there is every chance that he would loose interest and ability to wage war - his attention would be applied to something that he considered important, However, if you were to give LSD to. someone who was by nature a “warrior” be could use it’s awesome power to enhance and expand his perception and skills. - becoming like a real life Rambo, – Many people would experience insights and revelations that completely “re write” their view of the world and their place. within it ,– This could be for good or evil - The deciding factor would be the set and setting - LSD trips taken willingly in a supportive enviroment rarely go bad - but if it is. administered. to unwitting subjects it can become a devastatingly bad trip - Tripping out. groups of unsuspecting people would be real terror
SL: LSD has changed the world for the better more than most people appreciate- Due to it being illegal most people who have been positively affected by it are unlikely to declare it
Greg Vanderlaan What other plan has any chance at all to stop the killing? Anyone have any suggestions? Anything at all? No comments: Email This BlogThis! Share to Twitter Share to Facebook Share to Pinterest
Labels: concept, End War, Gaza, greg, hippie, history, israel, love, lsd, mkultra, peace, trip, Truth, valid, vanderlaan, war, what if Great Books: “Will” by G. Gordon Liddy. He is most famous for Operation GEMSTONE later called Watergate.
This book is an Autobiography and speaks of his entire life. Childhood, Navy, FBI, at the Whitehouse, incarceration and then release from prison.
He was involved with many Capers… Including Arresting Timothy Leary at Millbrook.
In 1971, E. Howard Hunt and Liddy planned to drug Daniel Ellsberg (Pentagon Papers) with LSD-25 at a dinner where Ellsberg was to speak… to befuddle him and make him appear to be a near burnt-out drug case… Classic MKULTRA…
However, MKULTRA was not revealed to the Public until years later… So Gordon Had Insider Knowledge… Fortunately, this project was not approved of in time to actually carry it out…
Classic… He never really thought out the consequences of his plans… For example, Daniel Ellsberg getting up to speak and shouting out “I’ve Been Poisoned” then Police testing the bowl of soup… Blowback!
Project MKUltra was first brought to public attention in 1975 by the Church Committee of the U.S. Congress, and a Gerald Ford commission to investigate CIA activities within the United States.
Finally! A wearable that feeds caffeine directly into your blood
To date, transdermal patches, containing infused substances like nicotine and caffeine, are kept hidden underneath your clothes, as they are not something people generally advertise.
These patches are typically placed near areas with high blood flow, so that the chemicals can enter and move through your body faster. But patch placement can lead to skin irritation, and general discomfort in wearing a sticky adhesive all day.
Enter Joule – a caffeine wearable designed to take away that discomfort, while also placing the patch in an area without much fat resistance, allowing the substance to flow faster into your body.
Joule isn’t exactly “smart” in the usual sense, as there’s no Bluetooth, notifications, or anything of the sort. Instead, it’s pretty simple in that it offers a way to put a patch in a high blood flow area without having to deal with any discomfort from placing a sticky patch on your body.
The company just launched an Indiegogo campaign, and has currently raised $3,283 out of $15,000 needed, as of publication.
The FDA-approved patch dispatches caffeine immediately — faster than drinking coffee — and has the same amount of caffeine as a medium cup of java, or 65mg.
While it begins quickly, the process proceeds slowly, as the Joule works “gradually for a steady supply of caffeine and energy without any of the typical energy crashes, jitters, or other negative effects of consuming your caffeine through beverages,” according to Joule’s Indiegogo page.
You’ll be getting the benefits of caffeine for four hours after placing the patch in the bracelet, and you can just take it off if you want it to stop.
The one-size-fits-all bracelet is made of a durable silicon material, and while it comes in a few colors, it doesn’t look too stylish. What does look decent is the watch version of the bracelet — which essentially adds a timepiece.
If you want to get into using patches and avoid the negatives of drinking coffee, including the jitters and coffee breath, the Joule bracelet will cost you $29 via the Indiegogo campaign, which is 20 percent off the projected market price. It comes with 30 patches, and you can always buy more separately when you run out.
The Joule Time model costs $99 on the Indiegogo page, and you need to be 18 or over to use either.
Also watch: Huawei Watch Review: A stunning Android Wear Watch
The transdermal/transmucosal drug delivery market consists of many companies including large and small pharmaceutical companies as well as large and small drug delivery companies. The competition among participants is intensifying not only within the specific category such as transdermal drug delivery but also among the competing drug delivery technologies to provide the best possible vehicle for administration of a particular pharmaceutical product.
The report profiles companies involved in the transdermal/transmucosal drug delivery market. Drug delivery companies have made tremendous strides in the transdermal/transmucosal drug delivery market. Several companies have products that are already enjoying market success while many others are at various stages of development. There is little doubt that this area of drug delivery will continue to flourish in the coming years.
Challenges remain for the development of transdermal/transmucosal drug delivery systems but continued research will likely break down the barriers that limit the types of drug molecules that may be delivered through the skin. The market is expected to be driven by various factors including the loss of patent protection for blockbuster drugs and the need to avoid the first pass effects of oral drug delivery. Additionally, with an added focus on active transdermal technologies, new applications will likely cause a resurgence of interest in transdermal delivery of products.
Transdermal and Transmucosal Drug Delivery Markets provides the following market information:
The Worldwide Market for Transdermal/Transmucosal Drug Delivery Technology and Pharmaceuticals, 2013-2020
The Worldwide Market for Pharmaceuticals Utilizing Transdermal/Transmucosal Drug Delivery Systems by Type, 2013-2020
The Worldwide Market for Pharmaceuticals Utilizing Transdermal/Transmucosal Drug Delivery Technologies, Market Share by Type, 2013-2020
Transdermal/Transmucosal Drug Delivery by Indication by Percent, 2015 (Smoking Cessation, Pain Management, Hormone, Cardio, Others)
The Transdermal/Transmucosal Drug Delivery Market by Region, 2013-2020 (United States, Europe, Japan, Rest of World, Global Market)
The Worldwide Market for Transdermal/Transmucosal Drug Delivery Systems, Distribution of Revenue by Pharmaceutical and Drug Delivery Component, 2013-2020
Leading Suppliers of Transdermal/Transmucosal Drug Delivery Technology
Key Topics Covered:
ONE: EXECUTIVE SUMMARY
Market Size and Growth
Total Transdermal/Transmucosal Drug Delivery Market
Transdermal/Transmucosal Drug Delivery Only Market
Competitive and Market Analysis
TWO: INTRODUCTION AND OVERVIEW
Scope and Methodology
Reasons for Transdermal/Transmucosal Drug Delivery Systems
Phases of Drug Action
Transdermal Drug Delivery
History of Transdermal Drug Delivery
Advantages of Transdermal Drug Delivery
Disadvantages of Transdermal Drug Delivery
Passive Transdermal Drug Delivery
Crystal Reservoir Technology
Active Transdermal Drug Delivery
Transdermal Microneedle Drug Delivery
Electrotransport Drug Delivery
Transmucosal Drug Delivery
Buccal Drug Delivery
Vaginal Drug Delivery
THREE: TRENDS AND DEVELOPMENTS
Novel Transdermal Approvals
Innovations in Transdermal Drug Delivery
Adhesive Technology and Issues
Adhesive Market Issues
Generic Transdermal Study Design Guidelines
Developments in Insulin Delivery
New Developments in Hormone Drug Delivery
New Mucosal/Buccal Delivery Systems
Other Drug Delivery Systems
Microneedle-Assisted Transdermal Drug Delivery
Controlled Thermal Energy Technology
New Ultrasound Technology
Transdermal Products in Development
FOUR: MARKET SIZE AND GROWTH
The Total Transdermal/Transmucosal Drug Delivery Market
Transdermal Subsegment Market
Transdermal/Transmucosal Market by Application
Transdermal/Transmucosal Delivery Technology Only Market
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