Oh gosh, I hope it’s helpful to you! ME2 is the one I play the least and so mod the least - and I haven’t done that one in ages.
It is a bit frustrating deciphering mods and which ones will work with which game when the creators aren’t very clear. There’s a lot of trial and error with it. I tend to stick with texture mods, though - and generally those are a bit clearer since you can see what’s exactly being modded.
I haven’t done ME3explorer with ME2 yet, but that’s the path I’d prefer to take, personally, because then no texmod and having to keep an active list of mods, etc. Just replace and done! It’s a lot more involved though, and there are plenty of chances to fuck up, so keep back ups if you go that route and remember, if it does all go to shit, starting over really isn’t that bad. And if you’d rather do texmod instead, totally okay.
With gibbed save editor, just keep duplicate saves and only change vector values a little bit at a time - and one at a time if you’re unsure what they do. That way you can undo stuff pretty easily.
Good luck and happy modding!