Working for those New York Dimes again. I illustrated some pretty great articles for this weekend’s New York Times Book Review section. Jeffrey Eugenides writes on Knausgård, and Schlosser writes on Åsne Seierstad’s book on Breivik. The print version of the paper also includes 3 spot illustrations, which you can see on my website.

Conjunto 9 cadeiras U design Tenreiro em jacarandá com acento em palhinha !!! Prontas para uso um Luxo!!! #cadeira #tenreiro #joaquimtenreiro poltrona #saladejantar #mesa #casa #receber #antique #antiquity #antiquario #antiqueshop #antiquestore #mobília #design #jacarandá #brasil #luxo #decoração #RobertaSobral #robertasobralescritoriodearte Whatsap 01199996-9624

(born Jan. 20, 1921, São Tomé—died Dec. 31, 1963, Lisbon, Port.), Francisco José Tenreiro was an African poet writing in Portuguese, whose verse expresses the sufferings of the indentured labourers of the islands of São Tomé and Príncipe. 

Tenreiro, the son of a Portuguese administrator and an African woman, spent much of his life in Portugal, where he earned a doctorate in geography from the University of Lisbon in 1961. Subsequently he worked as a professor at the Higher Institute for Overseas Social and Political Sciences in Lisbon and became a deputy representing Sao Tome and Principe in the Portuguese National Assembly.


Rehenes del día

nosotros que aprendimos el vocabulario nocturno

crecidos en secreto

iluminados por el sacerdocio del vino

estalla en júbilo la palabra

reune ausentes

promueve la claridad

organizamos la sombra con campanas escritas en el ámbito del exilio.

-Salvador Tenreiro, Secreta Claridad (1979).

Made for an animation, this scene is a tilt-down shot — hence the rough change of perspective into a flat style at the bottom half of the image. The ‘camera’ moves down and the perpective adapts to that movement (in an awkward perspective sort of way) until it reaches a totally flat shot of the street facade. The buildings are independent objects that will adapt to the speed of the motion. The image is never seen in its totality.

Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo.

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Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo.

J Biol Chem. 2015 Apr 10;290(15):9412-27

Authors: Mbefo MK, Fares MB, Paleologou K, Oueslati A, Yin G, Tenreiro S, Pinto M, Outeiro T, Zweckstetter M, Masliah E, Lashuel HA

Although α-synuclein (α-syn) phosphorylation has been considered as a hallmark of sporadic and familial Parkinson disease (PD), little is known about the effect of PD-linked mutations on α-syn phosphorylation. In this study, we investigated the effects of the A30P, E46K, and A53T PD-linked mutations on α-syn phosphorylation at residues Ser-87 and Ser-129. Although the A30P and A53T mutants slightly affected Ser(P)-129 levels compared with WT α-syn, the E46K mutation significantly enhanced Ser-129 phosphorylation in yeast and mammalian cell lines. This effect was not due to the E46K mutant being a better kinase substrate nor due to alterations in endogenous kinase levels, but was mostly linked with enhanced nuclear and endoplasmic reticulum accumulation. Importantly, lentivirus-mediated overexpression in mice also showed enhanced Ser-129 phosphorylation of the E46K mutant compared to WT α-syn, thus providing in vivo validation of our findings. Altogether, our findings suggest that the different PD-linked mutations may contribute to PD pathogenesis via different mechanisms.

PMID: 25657004 [PubMed - indexed for MEDLINE] http://dlvr.it/BLklNj