synapse

One synapse, by itself, is more like a microprocessor–with both memory-storage and information-processing elements–than a mere on/off switch. In fact, one synapse may contain on the order of 1,000 molecular-scale switches. A single human brain has more switches than all the computers and routers and Internet connections on Earth.
—  Stephen Smith
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The emotional sensitivity gene

Serotonin is one of the major neurotransmitters (i.e. chemicals) in the brain. It’s very connected to our emotions and so it’s not a coincidence that a lot of the drugs that are used to treat depression and anxiety act on the serotonin system in the brain. This is clearly a very important chemical for determining the nature of our emotional lives.

The serotonin transporter gene regulates serotonin in the brain. People are born with variations of this gene. The long variation clears serotonin out of the neural synapse more efficiently. The short variation is less efficient, which lets the serotonin hang around a little bit longer in the synapse. 

The short variation was originally considered a risk gene — but it’s now being thought of as a sensitivity gene.

Learn more about how the gene impacts our emotional responses →

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Poor Hellion (Julian Keller)…he has become another victim of the Terrigen Mists (a.k.a Inhuman Farts) that affects mutants. Though I am glad that the new normal-looking inhuman Synapse (Emily Guerrero) of the Avengers Unity Squad calls Medusa and the Inhumans (and I blame Black Bolt too) out on their dickery about releasing the terrigen mists into Earth and forcibly transforming some humans into Inhumans without consent as well as making mutants sick. 

- Uncanny Avengers v3 #6

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As Virginia Hughes noted in a recent piece for National Geographic’s Phenomena blog, the most common depiction of a synapse (that communicating junction between two neurons) is pretty simple:

External image

Signal molecules leave one neuron from that bulby thing, float across a gap, and are picked up by receptors on the other neuron. In this way, information is transmitted from cell to cell … and thinking is possible.

But thanks to a bunch of German scientists - we now have a much more complete and accurate picture. They’ve created the first scientifically accurate 3D model of a synaptic bouton (that bulby bit) complete with every protein and cytoskeletal element.

This effort has been made possible only by a collaboration of specialists in electron microscopy, super-resolution light microscopy (STED), mass spectrometry, and quantitative biochemistry.

says the press release. The model reveals a whole world of neuroscience waiting to be explored. Exciting stuff!

You can access the full video of their 3D model here.

Credit: Benjamin G. Wilhelm, Sunit Mandad, Sven Truckenbrodt, Katharina Kröhnert, Christina Schäfer, Burkhard Rammner, Seong Joo Koo, Gala A. Claßen, Michael Krauss, Volker Haucke, Henning Urlaub, Silvio O. Rizzoli

“People fear dying alone. The Avengers will find a fate far worse than that — dying with me in their heads.”Red Skull

Cover art for Uncanny Avengers Vol. 3 #020, “As the World Burns”

Art by Adam Kubert and Dean White