Study of ‘Fountain of Youth’ Protein Points to Possible Human Health Benefit

Individuals previously diagnosed with heart disease may be less likely to experience heart failure, heart attacks, or stroke, or to die from these events, if they have higher blood levels of two very closely related proteins, according to a new study led by a UC San Francisco research team.

One of these proteins, known as GDF11, has attracted great interest since 2013, when researchers showed that it could rejuvenate old mice. Based on these findings, scientists have speculated that drugs that increase GDF11 levels might reverse physiological manifestations of aging that lead to heart failure in people.

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The study was funded by the U.S. Department of Veterans Affairs, the National Institutes of Health, the Robert Wood Johnson Foundation, the American Federation for Aging Research, and the Ischemia Research and Education Foundation.

I actually usually use “Illust Studio”(It’s Manga studio in western side) for drawing my lineart, before I actually use Photoshop and its really getting out of control even if I turned off the pressure or with pressure. So I don’t recommend it much to use it as drawing. But for beginners, and you only have Photoshop, you can bear with it ww

But hopefully you’ll buy or get a new drawing program that is really good at making lines. You can only use Photoshop for some effects you want to apply on your drawing. It’s what I do! :^)

For doing the lineart, I’m pretty bad at teaching and explain how I did it since it’s how my hand moves when drawing ^^; In other words, its how I’m used to.

First, of course don’t forget to sketch up your drawings first. If you are unsure what you’re going to draw. Better go sketch first so you’ll know how you’ll draw them in proper way without sweat!  

Then!

Also don’t forget to experiment different brushes!! You might even find a kind of brush that fits your favorite way of drawing, because I do too before until I become dedicated to no pressure brush! (^∀^`;) Well don’t question me why all of the brush I love no pressure pen most…

Ah!! Before I forget it― The thinner the line the better too! Like this

Especially when drawing a robot/character in detailed and realistic way. Because thickening the brush will end up making your drawing look cartoonish… chibish― or simply looking like it’s not pretty fit for giant-detailed-looking-robots with thick lines;; ><

I hope my little tutorial will be quite helpful..! Even a bit;; I’m not really good at teaching my style but I tried! I wish you good luck on your progress in drawing!!  

Hi, I don’t normally do this, and I don’t have many followers but here it goes. A few years back my gram had several strokes that left her paralyzed on the left side of her face, arm and leg. She cannot hear or see out of her left side, nor move her mouth. Our insurance had cut us off because they told us she’d never get better. My grandpa took a job delivering papers in order to pay for her medicine. It’s only him and I taking care of her and we’re struggling to help her out. My gram needs the care she deserves. Please reblog or tell a friend any little bit helps :)

http://www.gofundme.com/helpmygram

Redrawing Language Map of the Brain

For 140 years, scientists’ understanding of language comprehension in the brain came from individuals with stroke.

Based on language impairments caused by stroke, scientists believed a single area of the brain – a hotdog shaped section in the temporal lobe of the left hemisphere called Wernicke’s region – was the center of language comprehension.  Wernicke’s was thought to be responsible for understanding the meaning of single words and sentences, two separate and critical functions.

But Northwestern Medicine scientists have updated and redrawn the traditional brain map of language comprehension based on new research with individuals who have a rare form of dementia that affects language, Primary Progressive Aphasia (PPA).

The new research shows word comprehension is actually located in a different brain neighborhood – the left anterior temporal lobe, a more forward location than Wernicke’s. And sentence comprehension turns out to be distributed widely throughout the language network, not in a single area as previously thought.

The paper was published June 25 in Brain.

“This provides an important change in our understanding of language comprehension in the brain,” said lead study author Dr. Marek-Marsel Mesulam, director of Northwestern’s Cognitive Neurology and Alzheimer’s Disease Center.

Mesulam also is a professor of neurology at Northwestern University Feinberg School of Medicine and a neurologist at Northwestern Memorial Hospital.

Knowing where language comprehension is located offers a more precise target for future therapies that could potentially protect or restore language function.

The stroke connection

Strokes cut off blood supply to regions of the brain and cause destruction of both neurons and fiber pathways passing through that region.

In the 1870s, a scientist named Carl Wernicke observed a specific region damaged by stroke and resulting language impairments. This area, consequently named Wernicke’s region, was identified as the seat of language comprehension.  

“People who had strokes that affected Wernicke’s region couldn’t explain what a word such as umbrella meant,” Mesulam said. “Secondly, they had difficulty understanding sentence construction. If you said, ‘Put the apple on top of the book,’ even if they understood the meaning of apple and book, they wouldn’t be able to carry out the command because they can’t understand the construction of the sentence.”  

Something doesn’t add up

But Mesulam, the world’s leading expert in PPA, for years had been puzzling over the fact that his PPA patients with damage in Wernicke’s area did not have the word comprehension impairment seen in stroke patients. They still understood individual words. And their sentence comprehension was inconsistent; some understood sentences; some didn’t.

“It was becoming clear over the many years I saw these patients, that there was some disconnect between what textbooks said and what we saw in our patients,” Mesulam said. “We did this study to analyze the discrepancy. The view of brain as seen from stroke did not match the view of the brain when seen from PPA.”

He and colleagues began a study of PPA patients, conducting quantitative MRI imaging of their brains and testing their language.

Northwestern scientist Emily Rogalski conducted the imaging in 72 PPA patients with damage inside and outside of Wernicke’s area. She measured cortex thickness in all of these areas. Cortex thickness is an indirect measure of the number of neurons and brain health. Thinning of the cortex in PPA indicates the destruction of neurons by the disease.

PPA patients still understand words

Rogalski, a research associate professor, found PPA patients who lost cortical thickness in Wernicke’s area still could understand individual words and had varied impairment of sentence comprehension. None of these patients had the global type of comprehension impairment described in stroke patients with Wernicke’s aphasia.

Severe word comprehension loss was only seen in PPA patients who had diminished cortical thickness in a region of the brain completely outside of Wernicke’s area, in the front part of the temporal lobe. This part of the brain is not prone to the effects of stroke, so its role in comprehension had been missed in prior language maps.

The discrepancy between the traditional map of comprehension and what was seen in PPA can be explained by the different ways the two diseases injure Wernicke’s area. In PPA, the neurodegenerative disease does not destroy the underlying fiber pathways that allow language areas to work together. But, in stroke patients, those critical highways passing through Wernicke’s had been blown up. So, the messages from other parts of the brain to the left anterior temporal lobe – the spot for word comprehension – were simply not getting through, Mesulam posits.

“What is happening here is no different from the charting of galaxies in outer space,” Mesulam said. “You look through one kind of telescope, you see one picture; you look through another infrared telescope, you get another picture. We are all in this pursuit of how to piece together different perspectives to get a better sense of how the brain works.”

“In this case, we saw a different map of language by comparing two different models of disease, one based on strokes that destroy an entire region of brain, cortex as well as underlying pathways, and the other on a neurodegenerative disease that attacks mostly brain cells in cortex rather than the region as a whole,” Mesulam said.

webmd.com
Could All Work and No Play Hurt Your Health?
Type A. Workaholic. Burning the candle at both ends. Married to the job. If any of those describe your approach to your career, and you’re letting those vacation days pile up, know this: You may be setting yourself up for some serious health problems.
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RECOGNIZING A STROKE

Sometimes symptoms of a stroke are difficult to identify. Unfortunately, the lack of awareness spells disaster.
The stroke victim may suffer severe brain damage when people nearby fail to recognize the symptoms of a stroke.
Now doctors say a bystander can recognize a stroke by asking three simple questions :

S * SMILE (ask the individual to smile)
T * = TALK (ask the person to speak a simple sentence) (Coherently) 

R * RAISE BOTH ARMS (look for one to be higher than the other)

  NOTE : Another ‘sign’ of a stroke is
1. Ask the person to ‘stick’ out their tongue.
2. If the tongue is ‘crooked’, if it goes to one side or the other that is also an indication of a stroke.

You can also recognize signs of a stroke by using F.A.S.T.

F * face- one side should droop a bit                                                                       

A * arms- raise your arms and look for them being uneven 

S * speech - ask them to say a simple sentence
T * time - you record the time it happened because it could be vital for doctors to know.

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