Researchers at NYU Langone Medical Center have found that navigational brain cells that help sense direction are as electrically active during deep sleep as they are during wake time—and have visual and vestibular cues to guide them. Such information could be useful in treating navigational problems, among the first major symptoms of Alzheimer’s disease and other neurological disorders.
In a report on their work in mice to be published in the journal Nature Neuroscience
online March 2, researchers found that head direction neurons continued
to code for the “virtual” direction of their gaze during sleep. In
fact, during Rapid Eye Movement (REM) sleep—a stage known
for intense dreaming activity in humans and during which brain
electrical activity is virtually indistinguishable from wake—the
‘needle’ of the brain compass in the mice surprisingly moved at the
same speed than observed during wake. During slow-wave periods of sleep,
it showed a 10-fold acceleration of activity, as if the mice turned
their head 10 times faster than during the time they were awake.
“We have long known that the brain is at work during sleep,” says senior study investigator Gyorgy Buzsaki, MD, PhD, the Biggs Professor of Neural Sciences at NYU Langone and its Neuroscience Institute. “But now we know how
it is working in one of the seemingly simpler senses—head
orientation—or our sense of where we look at in any given space. The
direction sense is an essential part of our navigation system, since it
can reset our internal compass and maps instantaneously, as, for
example, when we emerge from the subway and try to orient ourselves.”
further adds: “Finding that the activity of head direction neurons
shows coordinated patterns during sleep—as if substituting for the gaze
shifts in the navigating animal—demonstrates the brain’s efforts to
actively explore and coordinate its operations even when it disengages
from its interactions with the environment.”
Buzsaki says the
results further support his theory that brains in mammals do not
passively wait around to receive sensory inputs, but actively pursue
them, just like the active sense of head directionality persisted during
sleep in the mice.
For the two-year study, researchers videotaped
the head movements of mice and recorded the electrical activity in the
head-direction regions of the sleeping animals, specifically in the
antero-dorsal thalmic nucleus and postsibiculum regions of the brain.
These recordings were then compared with similar readings made in the
same mice while they were awake and navigating in various environments.
Adrien Peyrache, PhD,
a postdoctoral fellow and lead author of the study, further concludes,
“The coordinated activity during the majority of sleep likely represents
a consolidation of places, events and times, a sort of navigational
backup system in the brain, during which the brain stores a map to
Buzsaki says the research team plans to monitor other
parts of the mouse brain involved in more complex forms of behaviors to
see if similar neural activity patterns are at work. Researchers also
plan experiments to test whether head direction and navigation can be
electrically controlled and predicted in advance.