sherre

I love this! :) Gazelle & Judy!!!
Thank you, Mineralblu for shooting with us! Thank you Jennybelly for being so sweet & supportive of my Judy idea! I had a blast working with you both. :3
Photographer: @mineralblu
Cosplayers:
Gazelle - @jenny.belly
Judy Hopps - @wushuqt (Sherr Bear)
#zootopia #gazelle #judyhopps #cosplay #gijinka #cosplayers #cosplayersofinstagram #disney #disneycosplay #womenofcosplay #cosplaygirls #cosplayphotography #instacosplay #instacosplayer #japanfest #jfest #japanesefestival (at Houston Japan Festival)

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The Contribution of the Corpus Callosum to Language Lateralization.

PubMed: Related Articles

The Contribution of the Corpus Callosum to Language Lateralization.

J Neurosci. 2016 Apr 20;36(16):4522-33

Authors: Hinkley LB, Marco EJ, Brown EG, Bukshpun P, Gold J, Hill S, Findlay AM, Jeremy RJ, Wakahiro ML, Barkovich AJ, Mukherjee P, Sherr EH, Nagarajan SS

Abstract
UNLABELLED: The development of hemispheric lateralization for language is poorly understood. In one hypothesis, early asymmetric gene expression assigns language to the left hemisphere. In an alternate view, language is represented a priori in both hemispheres and lateralization emerges via cross-hemispheric communication through the corpus callosum. To address this second hypothesis, we capitalized on the high temporal and spatial resolution of magnetoencephalographic imaging to measure cortical activity during language processing, speech preparation, and speech execution in 25 participants with agenesis of the corpus callosum (AgCC) and 21 matched neurotypical individuals. In contrast to strongly lateralized left hemisphere activations for language in neurotypical controls, participants with complete or partial AgCC exhibited bilateral hemispheric activations in both auditory or visually driven language tasks, with complete AgCC participants showing significantly more right hemisphere activations than controls or than individuals with partial AgCC. In AgCC individuals, language laterality positively correlated with verbal IQ. These findings suggest that the corpus callosum helps to drive language lateralization.
SIGNIFICANCE STATEMENT: The role that corpus callosum development has on the hemispheric specialization of language is poorly understood. Here, we used magnetoencephalographic imaging during linguistic tests (verb generation, picture naming) to test for hemispheric dominance in patients with agenesis of the corpus callosum (AgCC) and found reduced laterality (i.e., greater likelihood of bilaterality or right hemisphere dominance) in this cohort compared with controls, especially in patients with complete agenesis. Laterality was positively correlated with behavioral measures of verbal intelligence. These findings provide support for the hypothesis that the callosum aids in functional specialization throughout neural development and that the loss of this mechanism correlates with impairments in verbal performance.

PMID: 27098695 [PubMed - in process] http://dlvr.it/L79073

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The Contribution of the Corpus Callosum to Language Lateralization.

Related Articles

The Contribution of the Corpus Callosum to Language Lateralization.

J Neurosci. 2016 Apr 20;36(16):4522-33

Authors: Hinkley LB, Marco EJ, Brown EG, Bukshpun P, Gold J, Hill S, Findlay AM, Jeremy RJ, Wakahiro ML, Barkovich AJ, Mukherjee P, Sherr EH, Nagarajan SS

Abstract
UNLABELLED: The development of hemispheric lateralization for language is poorly understood. In one hypothesis, early asymmetric gene expression assigns language to the left hemisphere. In an alternate view, language is represented a priori in both hemispheres and lateralization emerges via cross-hemispheric communication through the corpus callosum. To address this second hypothesis, we capitalized on the high temporal and spatial resolution of magnetoencephalographic imaging to measure cortical activity during language processing, speech preparation, and speech execution in 25 participants with agenesis of the corpus callosum (AgCC) and 21 matched neurotypical individuals. In contrast to strongly lateralized left hemisphere activations for language in neurotypical controls, participants with complete or partial AgCC exhibited bilateral hemispheric activations in both auditory or visually driven language tasks, with complete AgCC participants showing significantly more right hemisphere activations than controls or than individuals with partial AgCC. In AgCC individuals, language laterality positively correlated with verbal IQ. These findings suggest that the corpus callosum helps to drive language lateralization.
SIGNIFICANCE STATEMENT: The role that corpus callosum development has on the hemispheric specialization of language is poorly understood. Here, we used magnetoencephalographic imaging during linguistic tests (verb generation, picture naming) to test for hemispheric dominance in patients with agenesis of the corpus callosum (AgCC) and found reduced laterality (i.e., greater likelihood of bilaterality or right hemisphere dominance) in this cohort compared with controls, especially in patients with complete agenesis. Laterality was positively correlated with behavioral measures of verbal intelligence. These findings provide support for the hypothesis that the callosum aids in functional specialization throughout neural development and that the loss of this mechanism correlates with impairments in verbal performance.

PMID: 27098695 [PubMed - in process]

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*ATTENTION PLEASE!* For today’s #tbt, we wanted to honor Angel, who was saved by @rescuefromthehart. When Angel was first brought in, she had been clearly starved and weighed only ELEVEN freaking pounds. Angel’s road to recovery is all thanks to the @rescuefromthehart team and her forever family. Today, she’s all smiles.

Unfortunately, it was later revealed that Sherre Kay Buell, the woman who “tipped off” @rescuefromthehart about Angel, had actually been abusing animals in private. She then used them as opportunities for attention and publicity by saying she had “rescued” them. She is now facing criminal charges for her heinous actions against dogs, but it doesn’t end there. Tomorrow, her mental health will be assessed to see if she is fit to stand trial. Please sign the petition through @rescuefromthehart’s Facebook page to have this horrible abuser held accountable for her crimes.

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After dinner with my lovely friend Sherre at Chino Chinatown-so great to see her! Also hit The Cake Bar! (at Chino Chinatown)

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De Novo Mutations of RERE Cause a Genetic Syndrome with Features that Overlap Those Associated with Proximal 1p36 Deletions.

PubMed: De Novo Mutations of RERE Cause a Genetic Syndrome with Features that Overlap Those Associated with Proximal 1p36 Deletions.

Am J Hum Genet. 2016 Apr 13;

Authors: Fregeau B, Kim BJ, Hernández-García A, Jordan VK, Cho MT, Schnur RE, Monaghan KG, Juusola J, Rosenfeld JA, Bhoj E, Zackai EH, Sacharow S, Barañano K, Bosch DG, de Vries BB, Lindstrom K, Schroeder A, James P, Kulch P, Lalani SR, van Haelst MM, van Gassen KL, van Binsbergen E, Barkovich AJ, Scott DA, Sherr EH

Abstract
Deletions of chromosome 1p36 affect approximately 1 in 5,000 newborns and are associated with developmental delay, intellectual disability, and defects involving the brain, eye, ear, heart, and kidney. Arginine-glutamic acid dipeptide repeats (RERE) is located in the proximal 1p36 critical region. RERE is a widely-expressed nuclear receptor coregulator that positively regulates retinoic acid signaling. Animal models suggest that RERE deficiency might contribute to many of the structural and developmental birth defects and medical problems seen in individuals with 1p36 deletion syndrome, although human evidence supporting this role has been lacking. In this report, we describe ten individuals with intellectual disability, developmental delay, and/or autism spectrum disorder who carry rare and putatively damaging changes in RERE. In all cases in which both parental DNA samples were available, these changes were found to be de novo. Associated features that were recurrently seen in these individuals included hypotonia, seizures, behavioral problems, structural CNS anomalies, ophthalmologic anomalies, congenital heart defects, and genitourinary abnormalities. The spectrum of defects documented in these individuals is similar to that of a cohort of 31 individuals with isolated 1p36 deletions that include RERE and are recapitulated in RERE-deficient zebrafish and mice. Taken together, our findings suggest that mutations in RERE cause a genetic syndrome and that haploinsufficiency of RERE might be sufficient to cause many of the phenotypes associated with proximal 1p36 deletions.

PMID: 27087320 [PubMed - as supplied by publisher] http://dlvr.it/L5c86r

The History of Beads: From 100, 000 B.C. to the Present, Revised and Expanded Edition: Lois Sherr Dubin: 9780810951747: Amazon.com: Books



5.0 out of 5 stars
The Gift that Keeps on Giving


5.0 out of 5 stars
A must-have book for all serious beaders
The book is a visual feast as well as an authoritative history of beads. It has given me a greater appreciation of the richness and value of the beading making tradition. While I don’t collect antique beads, I think it’s important for the modern day jewelry maker, bead maker, bead vendor, etc. to understand the history of bead patterns and materials. Ms. Dubin’s book is simply wonderful! Go to Amazon

5.0 out of 5 stars
Beautiful, informative book
This is a beautiful book with great pictures. For a jewelry maker like me, it’s a great resource for info and ideas. I made an exact copies of some Tibetan earrings pictured in the book, and people always compliment me on them.It’s amazing to see the craftsmanship that was put into jewelry thousands of years ago andthat many jewelry styles we wear today are so similar, if not exactly the same, as ancient designs.I had taken this book out of the library a few times, but decided I wanted my own copy for reference and enjoyment. Go to Amazon

5.0 out of 5 stars
I love my book
I am chilean and I never saw a book like this. I am recently interested in beads and this is a wonderful way to become a beadlover. Go to Amazon

5.0 out of 5 stars
A Great History of Beads
The book is just what the title says it is: a history of beads around the world. Gives types, materials, places, times and purposes. Might get design ideas but this is not a how-to book. Wonderful fold-out timeline. Go to Amazon

5.0 out of 5 stars
Fabulous Book
I bought this book for my granddaughter for Christmas, read the whole book before I gave it to her, kept that book and bought her another one. It is as much a history book as it is an outstanding chronicle on beads in every culture. Well worth the cost. Go to Amazon

5.0 out of 5 stars
A Book of Marvels
I am an industrial designer and a jewellery maker and although not a bead collector this book is an huge source of information. It is beautifully edited and designed with astonishing photographs and deep content. I have almost all the books on the subject but this one is the most fantastic one. Go to Amazon

5.0 out of 5 stars
A Must for the Bead Collector’s Bookshelf
Probably the most comprehensive reference on one of the oldest artifacts of cognitive everyman, from 100,000 years ago to the present – the beautiful, mysterious, tactile, fascinating and irrepressible BEAD. Every bead owner and collector must have this revised and expanded edition, even if you own the original version of some 25 years ago. Go to Amazon