serratia

Serratia flowers

Serratia marcescens can form brilliant red colonies on LB agar due to the synthesis of the secondary metabolite prodigiosin. In the Microbiology teachinglab, we had students create pigment mutants of S. marcescens and these lovely shades of pink and white were collected for analysis.

This photo was taken from our sitewww.microbeworld.org. Submitted by: Phages_for_all_ages Thanks to the author(s): UIUC

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Ryan Returns Home from ICU

Ryan Returns Home from ICU

Ryan was discharged — directly from the ICU — and is now at home. We were fortunate to get out when we did because our area is getting quite the progression of precipitation: freezing rain, sleet, ice, and then snow.

Ryan gets his IV antibiotic this morning.

Over the next 14 days I must give him a strong (and somewhat uncommon) antibiotic intravenously. It is for the bacteria, serratia, that…

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Naplex revenge

xaize - since ya never check ur email lol…but are always on tumblr

Some helpful tidbits about antibiotics

How to memorize all the cephalosporins

First generation cephalosporins = the K’s; G+ bacteria and PEK (Proteus; E coli; Klebsiella)

Cefazolin (Kefzol) - IV only 1-1.5g IV q8h

Cephalexin (Keflex) - PO; 250-1000mg q6h

Cefadroxil (no brand) - PO

Second generation cephalosporins = the one Z and NMTT; G+ bacteria and HNPEK (Haemophilus; Neisseria; PEK)

Cefotetan (NMTT structure) - no alcohol d/t NMTT else disulfram like reaction; also hypoprothrombopenia (more bleeding); Bacteroides fragilis (anaerobic) activity

Cefuroxime (Zinacef; Ceftin) 

Third generation cephalosporins = Cefs, Ax, An, In; G+ bacteria and HNPEK+/-S (Serratia)

Cefdinir (Omnicef) 300mg PO BID or 600mg QD - the only suspension stored @ RT

Cefditoren (Spectracef) - with food PO

Ceftazidime (Tazicef; Fortaz) - 1-2g IV q8-12h; pseudomonas coverage

Cefibuten (Cedax) - no food PO

Cefixime (Suprax) - PO

Cefotaxime (Claforan) - 1-2g qIV 4-12h

Ceftriaxone (Rocephin) - 1-2g IV q12-24h (CI hyperbilirubinemic neonates or IV calcium in neonates 28 days old or less)

Cefpodoxime (no brand) - PO

Fourth generation = G+ with best G- activity or HNPEK+CAPES (Citrobacter; Acinetobacter; Pseudomonas; Enterobacter; Serratia)

Cefepime (Maxipime) - 1-2g IV q8-12h

Fifth generation = MRSA and no pseudomonas

Ceftaroline fosamil (Teflaro) - 600mg IV q12h

*Note that all the IV doses are 1-2g EXCEPT for cefazolin (1-1.5g) and ceftaroline (600mg)


How to memorize the fluoroquinolones

My good lungs (the respiratory FQs) need good coverage on (skin) - FQs cause photosensitivity!

Moxifloxacin (Avelox; Vigamox)

Gemifloxacin (Factive)

Levofloxacin (Levaquin) 

Norfloxacin (Noroxin)

Gatifloxacin (Zymaxid) - eye drops only

Ciprofloxacin (Cipro; Cipro XR; Ciloxan; Cetraxal; Ciprodex (+dexamethasone)

Ofloxacin (no brand)

No es “conspiranoia”, es Historia: Un ejemplo de experimentos biológicos sobre la población

Fuente: http://ift.tt/1Kw7gKC blog elrobotpescador.com15 julio 2015Copiado por BetotroniK Todo comenzó a finales de septiembre de 1950, cuando durante unos pocos días, un buque de la US Navy se dedicó a pulverizar una niebla cargada con dos tipos de bacterias, Serratia marcescens…

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How the US government experiment bioweapons on US citizens

How the US government experiment bioweapons on US citizens

How the US government conducted experiments 239 times with bioweapons on it’s US citizens. Evidence that the bacteria have led to the death. San Francisco is one of the most popular tourist cities in the world. Characteristic of the city’s steep hills, the fresh summers and fog. In September 1950 an US Navy ship sprayed two types of bacteria – Serratia marcescens and Bacillus globigii – into the…

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Genome sequence and comparative analysis of a putative entomopathogenic Serratia isolated from Caenorhabditis briggsae

Background: Entomopathogenic associations between nematodes in the genera Steinernema and Heterorhabdus with their cognate bacteria from the bacterial genera Xenorhabdus and Photorhabdus, respectively, are extensively studied for their potential as biological control agents against invasive insect species. These two highly coevolved associations were results of convergent #evolution. Given the natural abundance of bacteria, nematodes and insects, it is surprising that only these two associations with no intermediate forms are widely studied in the entomopathogenic context. Discovering analogous systems involving novel bacterial and nematode species would shed light on the #evolutionary processes involved in the transition from free living organisms to obligatory partners in entomopathogenicity. Results: We report the complete genome sequence of a new member of the enterobacterial genus Serratia that forms a putative entomopathogenic complex with Caenorhabditis briggsae. Analysis of the 5.04 MB chromosomal genome predicts 4599 protein coding genes, seven sets of ribosomal #RNA genes, 84 t#RNA genes and a 64.8 KB plasmid encoding 74 genes. Comparative genomic analysis with three of the previously sequenced Serratia species, S. marcescens DB11 and S. proteamaculans 568, and Serratia sp. AS12, revealed that these four representatives of the genus share a core set of ~3100 genes and extensive structural conservation. The newly identified species shares a more recent common ancestor with S. marcescens with 99 % sequence identity in rDNA sequence and orthology across 85.6 % of predicted genes. Of the 39 genes/operons implicated in the virulence, symbiosis, recolonization, immune evasion and bioconversion, 21 (53.8 %) were present in Serratia while 33 (84.6 %) and 35 (89 %) were present in Xenorhabdus and Photorhabdus EPN bacteria respectively. Conclusion: The majority of unique sequences in Serratia sp. SCBI (South African Caenorhabditis briggsae Isolate) are found in ~29 genomic islands of 5 to 65 genes and are enriched in putative functions that are biologically relevant to an entomopathogenic lifestyle, including non-ribosomal peptide synthetases, bacteriocins, fimbrial biogenesis, ushering proteins, toxins, secondary metabolite secretion and multiple drug resistance/efflux systems. By revealing the early stages of adaptation to this lifestyle, the Serratia sp. SCBI genome underscores the fact that in EPN formation the composite end result – killing, bioconversion, cadaver protection and recolonization- can be achieved by dissimilar mechanisms. This genome sequence will enable further study of the #evolution of entomopathogenic nematode-bacteria complexes. http://bit.ly/1LhsX3P #BMC