A discovery in the field of biomaterials may open new frontiers in stem and cancer cell manipulation and associated advanced therapy development. Novel scaffolds are shown enabling cells to behave in a different but controlled way in vitro due to the presence of aligned, self-assembled ceramic nanofibers of an ultra-high anisotropy ratio augmented into graphene shells.
“This unique hybrid nano-network allows for an exceptional combination of selective guidance stimuli for stem cell development, variations in immune reactions, and behavior of cancer cells”, says Professor Michael Gasik from Aalto University.
These scaffolds, for example, were shown to be able to direct the preferential orientation of human mesenchymal stem cells, similarly to neurogenic lineage, to suppress of major inflammatory factors expression and to immobilize cancer cells.
The results of the study were published in Nature Scientific Reports.
Caption: Fluorescent images of breast carcinoma cell line showing the morphological changes of cells grown on vertical GAIN scaffolds. Credit: Aalto University / Michael Gasik