scintigraphy

So I just found out about this

this is called scintigraphy – It’s basically shooting someone up with radioactive substances & waiting until these radiopharmaceuticals settle on your organ of choice;

then you capture the radiation coming out of the person’s body in form of photons 

they make your innards shine through your skin 

‘stars in your bones’          

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Je suis radioactif. Mes multiples entorses à la cheville droites auront-elles raison de moi? #scintigraphie #scintigraphy (à Hôtel-Dieu de Québec)

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Hashimoto thyroiditis: A "true" adenoma visualized as a hot nodule in the presence of overt hypothyroidism.

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Hashimoto thyroiditis: A “true” adenoma visualized as a hot nodule in the presence of overt hypothyroidism.

Hell J Nucl Med. 2011 Sep-Dec;14(3):304-6

Authors: Aloumanis K, Daramaras A, Ioannidou M

Abstract
A 63 years old woman with Hashimoto’s thyroiditis, on thyroxin treatment presented imaging studies concordant with a multinodular goiter, a “hot” nodule in the left lobe and partial suppression of the right lobe. After thyroxin withdrawal overt hypothyroidism developed, yet the patient’s imaging studies were not altered. This is a case of hypothyroidism in a patient with Hashimoto’s thyroiditis, multinodular goiter and a concomitant “hot nodule”, showed on scintigraphy, as a functioning adenoma in a non functioning thyroid. This finding is quite rare as no specific percentages are mentioned in the literature. To our knowledge this is the first such case described in Greece.

PMID: 22087454 [PubMed - indexed for MEDLINE]

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Gastric emptying of solids in children: reference values for the 13C-octanoic acid breath test

Abstract

Background

99mTechnetium scintigraphy (99mTS) is the ‘gold standard’ for measuring gastric emptying (GE), but it is associated with a radiation exposure. For this reason, the 13C-octanoic acid breath test (13C-OBT) was developed for measuring GE of solids. The objective of this study was to determine normal values for gastric half-emptying time (t1/2GE) of solids in healthy children.

Methods

Gastric emptying of a standardized solid test meal consisting of a pancake evaluated with 99mTS and 13C-OBT was compared in 22 children aged between 1 and 15 years with upper gastrointestinal symptoms. Subsequently, the 13C-OBT was used to determine normal values for GE of the same solid test meal in 120 healthy children aged between 1 and 17 years.

Key Results

The results showed a significant correlation (r = 0.748, p = 0.0001) between t1/2GE measured with both techniques in the group of children with upper gastrointestinal symptoms. In the group of healthy children, mean t1/2GE was 157.7 ± 54.0 min (range 71–415 min), but t1/2GE decreased with age between 1 and 10 years and remained stable afterward. There was no influence of gender, weight, height, body mass index, and body surface area on t1/2GE.

Conclusions & Inferences

Normal values for GE of solids measured with the 13C-OBT using a standardized methodology were determined in healthy children. We propose to use this method and corresponding reference ranges to study GE of solids in children with gastrointestinal problems.

We compared the 13C-octanoic acid breath test using non-dispersive infrared spectrometry with 99mTechnetium scintigraphy to measure gastric emptying of a standardized pancake test meal in children with upper gastrointestinal problems. We also established normal values for gastric emptying of this standardized pancake test meal measured with the 13C-octanoic acid breath test using non-dispersive infrared spectrometry in healthy children.

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Bone SPECT CT: An additional diagnostic tool for undiagnosed wrist pain

The diagnosis of wrist pain can be difficult to determine with clinical examination and conventional imaging techniques alone. Bone SPECT-CT (Single photon emission tomography with computerised tomography) is a hybrid imaging technique, that overlays functional bone scintigraphy in tomographic/3D mode with conventional CT. Data from the 2 modalities are complementary; areas of abnormal bone metabolism can be localised with anatomical precision, hitherto lacking in conventional bone scans, whilst structural information from the CT scan further embellishes the diagnostic information.
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Incidental Detection of Subcutaneous Myopericytoma of Trunk on FDG PET/CT and Bone Scintigraphy for Imaging of Colon Cancer.

Incidental Detection of Subcutaneous Myopericytoma of Trunk on FDG PET/CT and Bone Scintigraphy for Imaging of Colon Cancer.

Clin Nucl Med. 2016 Apr 27;

Authors: Demir SS, Sarikaya A, Aktas GE, Oz Puyan F

Abstract
Myopericytoma is a rare type of unusual soft tissue tumor with perivascular myoid differentiation. A 53-year-old man with the diagnosis of colon cancer was referred to Tc-MDP bone scan and F-FDG PET/CT for staging. A subcutaneous mass located in right lower back with heterogeneous FDG uptake was detected on PET/CT. There was increased osteoblastic activity on MDP bone scan in the same region. Mass was resected and subsequently confirmed as myopericytoma by histopathology.

PMID: 27124684 [PubMed - as supplied by publisher]

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Noninferior response in BRAF V600E mutant nonmetastatic papillary thyroid carcinoma to radioiodine therapy

Abstract

Purpose

As the most frequent and specific genetic alteration in papillary thyroid carcinoma (PTC), BRAFV600E has an intimate relationship with more invasive tumour and higher postoperative recurrence risk in PTC patients. We investigate the effect of radioactive iodine (RAI) therapy on the clinical outcome in PTC patients with the BRAFV600E mutation without distant metastases.

Methods

This retrospective study included PTC 228 patients without distant metastases who underwent total or near-total thyroidectomy and RAI treatment in our hospital from January 2011 to July 2014. The BRAFV600E status of the primary lesions was determined and the patients were divided into two groups according to the presence of the mutation. Serological and imaging data were collected at a median follow-up of 2.34 years after RAI administration. Suppressed and stimulated thyroglobulin (Tg), Tg antibody, diagnostic whole-body scintigraphy, and other imaging examinations were used to assess clinical outcome, which was defined as excellent response, indeterminate response, biochemical incomplete response and structural incomplete response.

Results

The BRAFV600E mutation was observed in 153 of the 228 patients (67.1 %). The clinicopathological features did not differ between the BRAFV600E mutatation and wild-type groups except age at diagnosis (P = 0.000), tumour size (P = 0.023) and TNM stage (P = 0.003). Older age and more advanced TNM stage were prevalent in the BRAFV600E mutatation group, whereas tumours were slightly larger in the BRAFV600E wild-type group. The response to RAI therapy was evaluated in both the entire series and the patients with a high recurrence risk, and no significant difference in response was found between the BRAFV600E mutatation and the wild-type groups (P = 0.881 and P = 0.851, respectively).

Conclusion

The clinical response to timely postsurgical RAI therapy is not inferior in BRAFV600E mutation PTC patients without distant metastases, which suggests that RAI therapy might improve the general clinical outcome in this patient group.

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Bone scintigraphy predicts bisphosphonate-induced osteonecrosis of the jaw (BRONJ) in patients with metastatic castration-resistant prostate cancer (mCRPC)

Abstract

Objectives

The aim of this study was to evaluate the role of bone scintigraphy (BS) in early prediction of clinically asymptomatic bisphosphonate (BP)-related osteonecrosis of the jaws (BRONJ) in patients with metastatic castration-resistant prostate cancer (mCRPC).

Material and methods

BS of mCRPC patients treated with BP was evaluated for pathologic tracer uptake of the jaws in BS suspicious for BRONJ. Results were compared to development of clinically evident BRONJ. Sensitivity, specificity and predictive values of BS for the detection of BRONJ as well as time from beginning of BP therapy to pathologic tracer uptake in BS and time from pathologic tracer uptake in BS to clinically evident BRONJ were determined.

Results

Thirty BP-treated patients were included. Nine patients (30 %) had pathologic BS lesions of the jaws. Six patients (20 %) developed BRONJ. Sensitivity and specificity of BS for BRONJ prediction were 67 and 79 %. Median time from the start of BP treatment to pathologic tracer uptake in BS was 28 months (range 10–33) and from pathologic tracer uptake in BS to clinically evident BRONJ 6.5 months (range 2–19). Pathologic tracer uptake in BS was significantly more often observed in patients who developed BRONJ compared to patients who did not (p = 0.049; OR 7.6).

Conclusions

Patients with pathologic tracer uptake in the jaws in BS significantly more often develop BRONJ. An unsuspicious BS is predictive for absence of BRONJ in the future.

Clinical relevance

We conclude that when BS has been performed, it should not only be used to assess tumour stage and treatment response but also to check for pathologic tracer uptake in the jaws in BS to detect BRONJ at an early stage in mCRPC patients receiving bisphosphonates.

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[Cervical macroadenoma causing hyperparathyroidism: Report of one case].

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[Cervical macroadenoma causing hyperparathyroidism: Report of one case].

Rev Med Chil. 2015 Mar;143(3):396-400

Authors: Zapata P A, Delgado F J, González V G, Arteaga U E

Abstract
We report a 59-year-old man with a history of hypertension, recurrent renal stones and a severe hypercalcemia of 14.9 mg/dl with a serum phosphorus of 2.4 mg/dl and a serum albumin of 3.6 g/dl. Physical examination showed a 4 cm left cervical nodule, consistent with the diagnosis of thyroid nodule. Parathyroid hormone (PTH) levels were 844 pg/mL (normal 15-65 pg/ml) and a cervical ultrasound examination disclosed a solid nodule in the lower left lobe of 40 x 30 x 25 mm, adjacent to the thyroid parenchyma. Abdominal ultrasound revealed bilateral renal stones. Parathyroid scintigraphy showed a high uptake of the left lower parathyroid mass and a bone densitometry showed bone density t scores of -1.2 in the spine, -2.0 in the right femoral neck and -3.5 in the distal radius. A review of his medical record revealed the presence of hypercalcemia for at least 4 years. He was admitted for hydration and administration of 4 mg zoledronic acid iv. At 24 hours, serum calcium dropped to 11.0 mg/dl, and a left thyroid lobectomy was performed including the lower left parathyroid gland. The pathology report showed a 22.6 g parathyroid adenoma. Intraoperatory PTH descended > 50%, consistent with successful parathyroidectomy. At 7 days after surgery serum calcium was 8.8 mg/dl, phosphorus 2.1 mg/dl, alkaline phosphatase 166 U/L, albumin 3.9 g/dL, PTH 230 pg/ml and 25-OH vitamin D 12.4 ng/ml. This finding was interpreted as secondary hyperparathyroidism due to vitamin D deficiency and “hungry bone”, being less likely the presence of residual or metastatic parathyroid tissue. A cholecalciferol load was administered, with significant descent of PTH.

PMID: 26005829 [PubMed - indexed for MEDLINE]

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Optic nerve sheath meningioma detected by single- photon emission computed tomography/computed tomography somatostatin receptor scintigraphy: a case report

Discussion Although meningiomas are common intracranial tumors, ONSMs as a specific subset are infrequent, accounting for only 1–2 % of all meningiomas [14]. Since morphological imaging techniques have their limitations in differentiating meningiomas from other tumors of the optic pathway [3, 6…
Source:Optic nerve sheath meningioma detected by single- photon emission computed tomography/computed tomography somatostatin receptor scintigraphy: a case report

Optic nerve sheath meningioma detected by single- photon emission computed tomography/computed tomography somatostatin receptor scintigraphy: a case report

Discussion Although meningiomas are common intracranial tumors, ONSMs as a specific subset are infrequent, accounting for only 1–2 % of all meningiomas [14]. Since morphological imaging techniques have their limitations in differentiating meningiomas from other tumors of the optic pathway [3, 6, …
Source: Optic nerve sheath meningioma detected by single- photon emission computed tomography/computed tomography somatostatin receptor scintigraphy: a case report