roher

Debuting at TCAF 2016 - Bird in a Cage by Rebecca Roher

ISBN 978-1-77262-005-4
7x9 inches, 112 pages, b/w trade paperback, $15

Once a sharp, strong-willed and independent woman, Roher’s grandmother’s life took an unexpected turn when an accident left her with a brain injury, leading to early onset dementia. An unlikely protagonist, grandma was an elderly woman trapped by her deteriorating mind, aging body and the walls around her. This story illuminates the often overlooked narrative of a senior, her complicated history and inner life. Loveable and tragic, she is determined to get back to a familiar place, to be home again. Roher digs deep into her grandmother’s personal history, learns to manage her escapes, and tries to create a safe environment for her. Exploring memory, the idea of place, and the power of song to transcend dementia, Bird In a Cage will tell the story of one woman’s search for home and the strength of family to try and bring her back.

For more info on all books debuting at TCAF 2016, please visit our Debuting Books page: torontocomics.com/books

ZiZi Two Finger Buttplug - Durchsichtig

ZiZi Two Finger Buttplug – Durchsichtig

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Für diejenigen, die etwas anderes suchen, ist dieser durchsichtige ZiZi Two Finger Buttplug ein spezielles und amüsantes Spielzeug. Durch das Design mit zwei Fingern sorgt dieser Buttplug nicht nur für ein besonders sinnliches Erlebnis, sondern auch für eine rohere Erfahrung. Durch den Stopper ist er sicher in der Anwendung kann genau wie ein echter Finger flexibel anal verwendet werden. Es ist…

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Spaghetti Carbonara Rezept #chefkoch

Spaghetti Carbonara Rezept #chefkoch

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Spaghetti Carbonara, auch Spaghetti nach Köhler Art genannt, zählt zu den bekanntesten Spaghettigerichten in Europa und gehört zu den Klassikern der italienischen Küche. Spaghetti oder auch Tortellini, roher Schinken, Eigelb, Butter, Salz, Pfeffer, Muskat und geriebener Parmesan sind die typische Grundzutaten die wir für die Zubereitung empfehlen.

Link zum Rezept: http://www.chefkoch.de/rezepte/1…

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PubMed: Characterizing Apolipoprotein E ε4 Carriers and Noncarriers With the Clinical Diagnosis of Mild to Moderate Alzheimer Dementia and Minimal β-Amyloid Peptide Plaques.: Related Articles

Characterizing Apolipoprotein E ε4 Carriers and Noncarriers With the Clinical Diagnosis of Mild to Moderate Alzheimer Dementia and Minimal β-Amyloid Peptide Plaques.

JAMA Neurol. 2015 Oct;72(10):1124-31

Authors: Monsell SE, Kukull WA, Roher AE, Maarouf CL, Serrano G, Beach TG, Caselli RJ, Montine TJ, Reiman EM

Abstract
IMPORTANCE: β-Amyloid peptide (Aβ) plaques are a cardinal neuropathologic feature of Alzheimer disease (AD), yet more than one-third of apolipoprotein E ε4 (APOE4) noncarriers with the clinical diagnosis of mild to moderate Alzheimer dementia may not meet positron emission tomographic criteria for significant cerebral amyloidosis.
OBJECTIVES: To clarify the percentage of APOE4 carriers and noncarriers with the primary clinical diagnosis of mild to moderate Alzheimer dementia near the end of life and minimal Aβ plaques noted at autopsy and the extent to which these cases are associated with appreciable neurofibrillary degeneration or a primary neuropathologic diagnosis other than AD.
DESIGN, SETTING, AND PARTICIPANTS: Data on participants included in this study were obtained from the National Alzheimer Coordinating Center’s Uniform Data Set, which comprises longitudinal clinical assessments performed at the AD centers funded by the National Institute on Aging. Neuropathology data are available for the subset of participants who died. A total of 100 APOE4 noncarriers and 100 APOE4 carriers had the primary clinical diagnosis of mild to moderate Alzheimer dementia at their last visit, known APOE4 genotype, died within the ensuing 24 months, and underwent neuropathologic evaluation on autopsy. The study was conducted from September 1, 2005, to September 1, 2012; analysis was performed from October 9, 2012, to March 20, 2015.
MAIN OUTCOMES AND MEASURES: Standardized histopathologic assessments of AD neuropathologic changes were the primary measures of interest in this study, specifically Consortium to Establish a Registry for Alzheimer’s Disease neuritic plaque density score, diffuse plaque density score, and Braak stage for neurofibrillary degeneration. The distributions of scores for these measures were the primary outcomes.
RESULTS: Of the 37 APOE4 noncarriers with minimal neuritic plaques, 16 individuals (43.2%) had Braak stages III to VI ratings, and 15 of the others (75.0%) met neuropathologic criteria for other dementia-related diseases. Of the 13 APOE4 carriers with minimal neuritic plaques, 6 individuals (46.2%) had Braak stages III to VI ratings and met neuropathologic criteria for other dementia-related diseases. Similarly, of the 7 APOE4 carriers with minimal neuritic plaques and Braak stages 0 to II, 4 participants (57.1%) were thought to have pathologic changes and alterations resulting from non-AD neuropathologic features.
CONCLUSIONS AND RELEVANCE: In this study, more than one-third of APOE4 noncarriers with the primary clinical diagnosis of mild to moderate Alzheimer dementia had minimal Aβ plaque accumulation in the cerebral cortex and, thus, may show limited or no benefit from otherwise effective anti-Aβ treatment. Almost half of the participants with a primary clinical diagnosis of mild to moderate Alzheimer dementia and minimal Aβ plaque accumulation had an extensive topographic distribution of neurofibrillary degeneration. Additional studies are needed to better understand and provide treatment for patients with this unexpectedly common cliniconeuropathologic condition.

PMID: 26302353 [PubMed - indexed for MEDLINE] http://dlvr.it/KMlmyq