region four

youtube.com
► POKEMON SM - Acerola - Speedpaint 【Artist-Dayuh】
Hey guys! This is my second speedpaint video that I made. Basically I am a beginner with video.XD But It's super fun to recording my draw. And~I'm really int...

https://youtu.be/WnUGrgp1t3Y

This is my second Speedpaint video that I made.
Basically I am a beginner with video.XD
But It’s super fun to recording my draw.
And~I’m really into it.
I hope you enjoy the video.
See you next week !^^

The original recordings of video is for 6 hr btw.


Acerola is my fav character in Pokemon SM !!
(The second is Mina~ BTW) >///<
And I love the map “ Thrifty Megamart (Abandoned Site) “
Mimikyu is so cuteeee~ ahh

(GIF ver ↓ ) 

Antibodies (Human)

  • The ‘foot’ (bottom) of the antibody is known as the Fc fragment - binds to cells, binds to complement = effector function (kills or removes antigen)
  • The top (antigen binding) is the Fab fragment
  • Chains are held together with disulphide binds
  • Associated molecules allow intracellular signalling 
  • Normally 3X constant heavy chain domains per chain and a hinge region (except μ and ε which have 4 and no hinge region)

Classes of Immunoglobulins

The five primary classes of immunoglobulins are IgG, IgM, IgA, IgD and IgE,  distinguished by the type of heavy chain found in the molecule. 

  • IgG - gamma-chains
  • IgMs - mu-chains
  • IgAs - alpha-chains
  • IgEs - epsilon-chains
  • IgDs - delta-chains.

Differences in heavy chain polypeptides allow different types of immune responses. The differences are found primarily in the Fc fragment. There are only two main types of light chains: kappa (κ) and lambda (λ), and any antibody can have any combination of these 2 (variation).

IgG 

  • monomer
  • Gamma chains
  • 70-85% of Ig in human serum. 
  • secondary immune response 
  • only class that can cross the placenta - protection of the newborn during first 6 months of life
  • principle antibody used in immunological research and clinical diagnostics
  • 21 day half life
  • Hinge region (allows it to make Y and T shapes - increasing chance of being able to bind to more than one site)
  • Fc strongly binds to Fcγ receptor on phagocyte - opsono-phagocytosis
  • Activates complement pathway

IgM

  • Serum = pentamer 
  • Primary immune responses - first Ig to be synthesised
  • complement fixing 
  • 10% of serum Ig 
  • also expressed on the plasma membrane of B lymphocytes as a monomer - B cell antigen receptor
  • H chains each contain an additional hydrophobic domain for anchoring in the membrane
  • Monomers are bound together by disulfide bonds and a joining (J) chain.
  • Each of the five monomers = two light chains (either kappa or lambda) and two mu heavy chains.
  • heavy chain = one variable and four constant regions (no hinge region)
  • can cause cell agglutination as a result of recognition of epitopes on invading microorganisms. This antibody-antigen immune complex is then destroyed by complement fixation or receptor mediated endocytosis by macrophages.

In humans there are four subclasses of IgG: IgG1, IgG2, IgG3 and IgG4. IgG1 and IgG3 activate complement.


IgD 

  • B cell receptor
  • <1% of blood serum Ig
  • has tail pieces that anchor it across B cell membrane
  • forms an antigen specific receptor on mature B cells - consequently has no known effector function (don’t kill antigens, purely a receptor) (IgM as a monomer can also do this)

IgE 

  • Extra rigid central domain
  • has the most carbohydrates
  • IgE primarily defends against parasitic invasion and is responsible for allergic reactions.
  • basophils and tissue mast cells express very high affinity Fc receptors for IgE - mast cells then release histamine
  • so high that almost all IgE is bound
  • sensitizes (activates) mucosal cells and tissues 
  • protects against helminth parasites

IgE’s main purpose is to protect against parasites but due to improved sanitation these are no longer a prevalent issue across most of the world. Consequently it is thought that they become over activated and over sensitive while looking for parasites and start reacting to eg pollen and causing allergies.

IgA

  • Exists in serum in both monomeric (IgA1) and dimeric (IgA2) forms (dimeric when 2 Fcs bind via secretory complex)
  • 15% of the total serum Ig.
  • 4-7 day half life
  • Secretory IgA2 (dimer) = primary defense against some local infections
  • Secreted as a dimer in mucous (e.g., saliva, tears)
  • prevents passage of foreign substances into the circulatory system


Isotype: class of antibody (IgD, IgM etc)

Allotype: person specific alleles 

Idiotype: (hyper) variable region - antibody specificity 

Albanian iso-polyphony is a traditional part of Albanian folk music and as such is included in UNESCO’s intangible cultural heritage list. Among Albanians, all four regions of Lalëria (Myzeqe), Toskëria, Çamëria, and Labëria have the polyphonic song as part of their culture. Among Albanians a related form of polyphonic singing is also found in northern Albania in the area of Peshkopi, the Albanian communities of Kaçanik in Kosovo, the areas of Polog, Tetovo, Kičevo and Gostivar in Macedonia and the region of Malësia in northern Albania and southern Montenegro. The region of Labëria is a particular region for multipart singing. Songs can be of two, three, or four parts. Two part songs are sung only by women. Three part songs are more diffused and can be sung by men and women. Four part songs are a Labëria specialty. Research has shown that four part songs have come after three part ones and that they are the most complex form of polyphonic singing.

Highway 666 is one of the most famous roads in America- and also one of the most haunted places in the country. The road is located in a region known as the “Four Corners,” which includes Utah, Colorado, Arizona, and New Mexico, and was nicknamed the Devil’s Highway due to the large amount of fatalities and accidents that occurred on it. Witnesses have claimed that when night falls, they start to see headlights behind them. Even after picking up their speed, the car still seems to gain on them. Many people pull over to evade it, while others watch it speed past. Some even look back up and see that it was never there. A similar legend arose in which an evil spirit in a truck would essentially do the same thing, but instead the spirit would try to hit them, actually hit them, or jump through their windows and attack them. Some have claimed that the hounds of hell have ran alongside their car, slashed people’s tires with their razor sharp teeth, or even jumped into the car and attacked them, which people have started to use as a rationale for the many accidents on the road. There is also believed to be a benevolent spirit of a young girl at the side of the road that disappears once someone gets close to it. Lastly, skin walkers have reportedly been seen transitioning into animals on the road and then suddenly turning back to their true form, scaring individuals into crashing. Another story has been passed around about a skin walker urging people to not continue down the road, and if they disobey the command, the creature will appear next to them and steal their souls. Nonetheless, the road was renamed to Route 491, and the number of fatalities has drastically decreased since then.

Seasons, Months and Festivals

Though most have forgotten the old elven names for the Gods they are still seen in the names of the Elven and Dwarven cycles and months of the year, though most remember them in the common tongue of Forged beings. Additionally there are a few key celebrations that occur over the year:

There are four seasons of Rúmerion, 12 months and each holding festivals specific to the gods, month and region of Rúmerion. The four seasons are as follows:

Winter - Wyrtir (December, January, February)
Spring - Izril (March, April, May)
Summer - Naryar (June, July, August)
Autumn - Durak (September, October, November)

January – Aydayar

The Festival of Celebration.

The FoC is a folk dance that goes on from sunset to sunrise on the first day of the year. There is a strong magical presence during this time and spells are more potent. There is also a first feast where communities band together in celebration. Especially Gnomes, Halflings, Dwarves, Humans and Dragonborn practice this aspect of the celebration. During the feast offerings to the Gods are made.


The Red Lotus Dance

similar to the Festival of Celebration but dance not feast focused. Celebrated by Elves, Drows and Tieflings

February – Ayluiner

The Lovers Dance

In celebration of the unification of Ayda and Ayluin joining together, offerings are made to them. Couples often marry and give gifts to each other during this period.

March - Nimuner

Father Wakes

The days start to lengthen and winter ends. Dances and Celebrations occur with offerings made to the gods as thanks for making it through the winter.

April - Zaornar

Celebration of the Sea – The Dolphin Dance

(celebrated by the Elves)

The Elves do the dolphin dance in thanks to the sea for its bounty. Feasts are held with aquatic foods and aquatics luxuries such as shells are traded, collected and highly sought after.

May - Merien

Celebration of the Tree – The Seed Ceremony - 

(celebrated by Gnomes and Halflings)

In the same fashion as the dolphin dance the Elves also celebrate nature during this month. The Gnomes and Halfling’s celebrate by collecting seeds from the trees that are deemed as the most pure or with the tastiest fruit and they replant their groves to match.

June - Jandaren

Celebration of the Hunt – The Boar Chase

(celebrated by Dwarves, Humans and Orcs)

Like the last two the elves celebrate the animals of Rúmerion. Hunts take place after highly prized beasts like Golden Stags. For the Dwarves, Humans and Orcs this celebration focuses on the hunt for the White Boars. The Dwarves take this a step further and look for possible War Boars to capture and train for their army.

July - Vanyer

The World Meeting & The Summers Dance 

(TWM rotates between each capital)
In honour of the Grand Council who met to stop Uther Duquette, a Grand Council meet to discuss trade, discovery, knowledge and disputes. The common folk celebrate the height of summer with a dance and a feast.

August - Ither

The Wolf Moon & Naryar’s Feast

With the end of summer the wolves come prowling, all races on Rúmerion have a grand feast in celebration of the harvest, bountiful or not.

September - Aerilayer

Father Sleeps – The Great Harvest

With the Equinox the night begins to last longer. Offerings are made by all to the Gods in order to appease them for a kind winter.

October - Ruyer

The Witches Dance – Dance of Golden Spells

(celebrated by Elves, Dwarves and Halflings)

Darkness has set in and magic becomes far stronger now. Golden comets often pass over the sky. Rumors of the Pumpkin King return for the mists on Rúmerion’s moors.

November - Sanon

The Warriors Dance

In celebration of Sana, veterans and war in general. Dances and Sacrifices to Sana and the gods occur. Orc warriors receive their clan tattoos now.

December - Virion

The Gnome Moon Celebration – The Snow Moon

(celebrated by Humans)At the end of the year gifts are given in thanks to family and friends. Gnome children receive their familiars now.

☼  art by novatious-art / lets-just-start-over


Hello, Pokémon Fans!

It’s been talked about many times, and after many months of wishful dreaming, we can finally proudly say that we will be hosting a Namelessshipping Week on September 24th to 30th! A great way to finish off this month while the release of Ultra Sun and Ultra Moon draws near!

Each day has a certain theme or topic for you to produce work from. Here are the prompts which your fan works should be based on; you’re free to interpret the prompts however you want! You can choose one of the prompts for that day - or a mix! It’s entirely up to you!

🌟 Day One: Childhood / Family / Promises
🌟 Day Two: Defeat / Mistakes / Snow
🌟 Day Three: Colours / Reunion / Favourite Region
🌟 Day Four: Flowers / Protecting Eachother / First Date
🌟 Day Five: Sharing Beds / Hands / Battle
🌟 Day Six: Beach / Honeymoon / Fireworks
🌟 Day Seven: Anything Goes!

Once you’ve made your contribution, post it to Tumblr, and use #namelessweek within the first five tags of your post to make it easier for us to find in Tumblr’s search engine.

Read the rules before you participate, please! If you have any questions or concerns, please send us a message and we’ll address it. Help spreading the word would be greatly appreciated!

Smell ya later!

nytimes.com
Ruined ‘Apartments’ May Hold Clues to Native American History
By Jon Hurdle

On the site of a former auto-repair shop here, broken stone walls mark the site of a 900-year-old village that may yield new insights into an ancient desert culture.

The ruins are what remains of two “great houses” — apartment buildings, essentially — that formed a northern outpost of a civilization based at Chaco Canyon, about 100 miles away in northwestern New Mexico.

Archaeologists from the Crow Canyon Archaeological Center, in nearby Cortez, have just begun the first systematic excavation of this site in an effort to learn how its residents lived in the early 1100s, and how they related to the wider Chaco culture.

In particular, the Northern Chaco Outliers Project aims to determine when the village was occupied, how many people lived there, and whether they did so during an extended drought of 1130-1180, which may have accelerated a northward movement of people from Chaco.

The project is the first in many years to systematically excavate any of about 250 great houses that were built in the region known as Four Corners, said John Kantner, an archaeologist at the University of North Florida.

“We have so little understanding of the role of great houses and the relationship between others and Chaco Canyon itself,” said Dr. Kantner, who excavated Blue J, another Chaco-related site in New Mexico.

The project here has the potential to “fill in the gaps about the outlying great houses,” he said.

Susan Ryan, director of archaeology at the Crow Canyon Archaeological Center, leads the Haynie Site project. Credit Nick Cote for The New York Times

Keep reading

Legend of Welp! #89

Ganondorf: I’m just too tough to cry.

Nabooru: Biologists say in the future the entire desert will be crawling with creatures called “Sand Seals,” a species of seals that have acclimated to the deserts and can act as a desert alternative to horses or camels.

Ganondorf, tears streaming down his face: That’s… that’s so adorable…


(I think the Gerudo desert may be my favorite of the four regions in Breath of the Wild)

anonymous asked:

So what if BOTW is the end of the kingdom of Hyrule? These people have been governing themselves for 100 years, and this Zelda seemed more of a scholar than a ruler. Maybe she is content to live her life as a scholar with Link? Maybe the years folllwing are plagued with civil war if she tries to take command? Thoughts??

At this point Zelda is a princess in name only. After 100 years of autonomy outside of ye olde Hylian monarchy, nearly every surviving town and village has settled into more of a City State style of existence. Hyrule’s authority over the other races like the Zora and the Rito was vague at best even 100 years ago and they took the easiest to self governance. The Gerudo took to it especially well, which allowed them to develop both the strongest economy and standing military force over the course of only a century. It wouln’t be unreasonable to think that the head of each city-state formed a council to help ease inter-city relations and policy. Zelda may be given a seat at this council out of respect, but she’d be little more than a figurehead.

The only people still loyal to the royal line are the Sheikah, as has been their purpose for thousands of years. Many within the tribe even see it as a positive that Kakariko now serves as the home of the Royal bloodline. By keeping Zelda and her potential heirs close and possibly even mixing the Sheikah bloodline with that of the Goddess Hylia, it would enable them to keep a much closer eye on the cycle of reincarnation and rebirth.

I guess it would be best to say that Hyrule as a kingdom is over. The few left alive who remember it are old and possibly bitter. With only one village lending support to her name, Zelda would be unable to reassert her rule over the entire region. The four non-Hylian races would likely ignore her attempts to reunify the kingdom and of the Hylian settlements Hateno Village in particular would refuse to come back under her rule, seeing as they believe it was their fort that broke the tide of the Calamity 100 years ago.

Of course, Hyrule as a region still exists. Isolated by the ocean, massive gorges and a scorching desert would still force both economic and political ties between the towns and villages. Perhaps eventually boats would be invented that are capable of sailing the vast and unforgiving ocean. Maybe the Rito will discover a path through the strong winds that cut across the trenches. Out of all the peoples, the Gerudo would continue to rank the highest in terms of military, economic and political power. As the only race with access to a land route leading out of the region, they would control trade between Hyrule and other regions far beyond. This exclusive trade access gives them great influence over the rest of the region of Hyrule, essentially making them the defacto rulers of the region. While not technically a monarch, the council would yield to the desires of Riju and her descendants in important matters. Each city-state retains its own autonomy, but the chief of the Gerudo would be seen as something of a higher authority to which the other members of the council would make their cases.

In regards to the potential of a civil war, I ask this: With what army? Zelda has no troops at her command. At best she has Link and the handful of Sheikah who are actually fit to fight. It would be a losing battle. The Gorons would just laugh and go back to their burning mountain, the Rito could just destroy the bridges to their town and rely on their wings to go to and from home. The Zora would avoid open hostility in honor of the bond between Link and the Zora people but politely refuse to cooperate. The Gerudo would rise to the threat and crush Zelda’s small force.

Can’t really think of a good way to end this one, it was pretty much just a stream of consciousness cause and effect type of ordeal. I hope you enjoyed it!

[Lonely Voe]

anonymous asked:

Could you please describe each faction/kingdom and who rules each one? like a description of the geographic layout if that's at all possible?

Ross appears and shoves a crude, slightly tattered map into your hands, seeming peeved.

“Alright, listen closely ‘cause I don’t have the patience to say this twice. Back before all this Hatter crap started, there were four regions all living in harmony, or what ever, blah blah blah… 

“The Heartland is pretty self explanatory; the place with a big fuckin’ castle in the middle and the biggest population. This was where Mark’s family ruled. Used to be a fun place, kids playing and merchants on every street. Now it’s the only place that the Court has managed to keep under their control, and everything but the castle itself is in ruins.

“The Sea Kingdom was where Ethan’s family was in control. It’s mainly beaches and ports. Used to be a busy place, with fishermen and casual boaters, people looking to vacation, and shell collectors. His family was very wealthy, owned the whole place. Now it’s pretty barren there, but The Hatter likes to hang around there when he’s not.. busy.

“The Mountain region is a mining and industrial region. Its relatively untouched so far, but mostly ‘cause it isn’t much of a pleasant place to live, or even to work. People only go there anymore as an attempt to escape The Hatter, or to slave away in the mines. Anyway, Tyler used to work in the mines, and as an inventor’s apprentice. He was well known for his skills with mechanics and making little gadgets.

“And then there’s The Forest. That’s where Jack used to live. He was part of a group of nomads that maintained control of the forest and took care of it. They were pretty peaceful people, in charge of agriculture and livestock, but were well trained fighters. Pacifist ninjas or something, I still don’t understand, but to each their own… Few nomads are left now, and those that are still around have gone into hiding deep in the woods. The Hatter holds total control over the Forest, in every way. The Forest bends to his will, now. Kind of a kick in the face to all the hard work the Nomads put into keeping it a peaceful and undisturbed land.”

i finally have a “that sounds fake but okay” story of my own

washingtonpost.com
Analysis: The Hunt for Lost Cities.

“Using numbers scrawled by Bronze Age merchants on 4,000-year-old clay tablets, a historian and three economists have developed a novel way to pinpoint the locations of lost cities of the ancient world.

The ancient city of Kanesh, located in the middle of modern-day Turkey, was a hub of trade in the Anatolian region four millennia ago. Modern-day archaeologists have unearthed artifacts from the city, including more than 23,000 cuneiform texts, inscribed in clay by ancient Assyrian merchants.”


How exciting. -X

Black History Month: NCAA Gymnasts

February 13th- Tyra McKellar (Towson)

Tyra McKellar (born October 22nd 1996) is a former level 10 gymnast who is currently a junior at Towson University, majoring in deaf studies. She did her club training at Frederick Gymnastics Club under Heather Galpin.

Pre-collegiate Achievements:

  • 2014 JO NIT Qualifier 
  • Qualified for JO Regionals all four years of high school 
  • 2013 Maryland state champion on bars and in the all-around 

Collegiate Bests:

  • Vault: 9.800
  • Bars: 9.900
  • Beam: 9.850
  • Floor: 9.900

Collegiate Achievements (to date):

  • Competed as a freshman at the 2015 Auburn regional as an individual in the all-around
  • First-team All-EAGL
  • Has earned EAGL Rookie of the Week honours