So when I was in high school a writer and former publisher visited our school to give advice. He told us that when publishers receive a manuscript from someone unknown they generally reject it. This is without reading anything. Sometimes it’s that they don’t have time or don’t like the title, or simply just don’t want to read anything. He also said that when they do read it, it’s generally just the first couple sentences, if it doesn’t immediately grab their attention or has a cheesy opening like ‘once upon a time’ or 'it was a dark and stormy night’ they immediately reject it. His advice to us was keep sending them in, make sure the opening is exciting, and try to have a catchy and interesting title. While this may not be every company or things may have changed, this was the advice given.