pocket dr

You’re Worth Melting For

For snowflake anon & Dr. Anon:

Imagine a pocket-sized you getting inspired by the famous Disney movie Frozen and wanting to make your own Olaf. Standing outside in the freshly-coated yard bundled up head from toe, you stare back at the snowman, who is the same height as you, in its button eyes and place the baby carrot where its nose is supposed to go. The snow crunches under your boots as you step back and smile at your pocket-sized Olaf. He smiles at you with his square teeth (you used a square-shaped piece of gum), and with a satisfied sigh, you turn around to tell Namjoon and Hoseok you’re ready to go inside, but you stop yourself. Hoseok holds Namjoon’s hands in his and have them close to his mouth blowing on them to get them warm because Namjoon forgot his gloves (he didn’t think you’d be out in the cold this long). Clearing your throat while gaining their attention, Namjoon pulls his hands away from Hoseok’s embarrassed. Acting like nothing happened, Namjoon asks if you’re ready to go inside. Biting your lip to keep from smiling, you nod your head.

High cocaine doses ‘can cause brain to eat itself’

A study of mice found that the drug can trigger out-of-control “autophagy”, a process by which cells digest themselves.

When it is properly regulated, autophagy provides a valuable cleanup service – getting rid of unwanted debris that is dissolved away by enzymes within cell “pockets”.

Dr Prasun Guha, from Johns Hopkins University School of Medicine in the US, who led the research published in the journal Proceedings of the National Academy of Sciences, said: “A cell is like a household that is constantly generating trash. Autophagy is the housekeeper that takes out the trash – it’s usually a good thing. But cocaine makes the housekeeper throw away really important things, like mitochondria, which produce energy for the cell.”

The scientists carried out postmortems that showed clear signs of autophagy-induced cell death in the brains of mice given high doses of cocaine. They also found evidence of autophagy in the brain cells of mice whose mothers received the drug while pregnant.

The scientists showed that an experimental drug called CGP3466B was able to protect mouse nerve cells from cocaine death due to autophagy. Since the drug has already been tested in clinical trials to treat Parkinson’s and motor neurone disease, it is known to be safe in humans. But much more research is needed to find out whether the drug can prevent the harmful effects of cocaine in people, said the team.

Co-author Dr Maged Harraz said: “Since cocaine works exclusively to modulate autophagy versus other cell death programs, there’s a better chance that we can develop new targeted therapeutics to suppress its toxicity.”

Image: There were clear signs of autophagy-induced cell death in the brains of mice given high doses of cocaine. Credit: OJO Images/Alamy

Source: Guardian (Press Association)

What’s In My Pencil Case?

Hey guys, I just decided to get into that studyblr spirit and do a quick little post on what I carry for my day-to-day school purposes in case anyone was wondering c:

Let’s Begin~

1. Nomadic PE-09 Flap Type Pencil Case

2. TI-84 Scientific Calculator

3. Casio 4-Function Calculator

4. Monami Blue Highlighter

5. Zebra Mildliner(s) - Yellow and Green

6. Pilot Hi-Tec-C Maica Gel Pen(s) - Black and Red

7. Morning Glory Pocket Eraser - Purple

8. Pilot Dr. Grip 0.5mm Lead Pencil (it shakes c:)

9. Tombow Mono 2way Correction Tape + Eraser

10. Kokuyo Campus Student Eraser

11. Pentel 0.5mm Lead

12. Line Friends Tabs/Sticky Notes (a friend got them from Taiwan??)

13. 1 sm binder clip

So, as you can see, this pencil case is really great for holding lots of stuff, and I am also a little bit of a stationery junkie and should probably stop…but I just have to buy all the pens! Not just one, but all. On a more serious note, you can find almost all of these products on jetpens.com! It’s a really great site for ordering Asian stationery products!~

Anyways, hope you enjoyed and have a good day everyone!