Boston Suburb future home of World's Largest Automated Living Cell Manufacturing Plant

Tucked in a Boston suburb, construction is under way for what will soon be the world’s largest automated living cell manufacturing plant. 

Organogenesis is in the midst of a major, multi-year expansion of its global headquarters, R&D and manufacturing facilities in Canton, Mass.

…The Massachusetts Office of Business Development worked closely with Organogenesis to create a $12.9 million incentive package, including the Life Sciences Center grant, as well as tax credits for research-and-development expansion.  

…As part of the agreement, Organogenesis committed to creating 280 new in-state jobs by 2013, and specifically to creating 17 new in-state jobs in 2011.  In the first quarter of 2011, the company surpassed its target expectations for 2011 Massachusetts job creation by adding 19 in-state jobs, with an additional 35 open positions.

Groundbreaking ceremonies for the work were held today, work will be completed in 2013.

For openings at Organogenesis, check their careers site. (And if you want you can find out who you know inside through StartWire.)

Adventitious organogenesis induced in sweet orange (Citrus sinensis L.) var. “half-blood” maltese: morphogenetic and histological study

Kaouther Benmahmoud, Emna Jedidi, Asma Najar, Rachida Ghezel, Claire Kevers, Ahmed Jemmali, Nadhra Elloumi

Laboratory of plant protection, National Institute of Agronomic Research of Tunisia, Tunisia

Laboratory of horticulture, National Institute of Agronomic Research of Tunisia, Tunisia

Plant molecular Biology and Biotechnology, University of Liege, Belgium

Key words: Citrus, Somatic embryogenesis, Organogenesis, Histology, Style/stigma.


Tunisian citrus crops are faced to several abiotic and biotic constraints among which virus and virus-like diseases are incurable. The production of virus-free plants systematically needs the use of in vitro techniques. In this context, somatic embryogenesis and further plantlet regeneration of the Tunisian “half-blood” Maltese orange were obtained using explants consisting in style/stigma collected from unopened flowers.Somatic embryos were induced on Murashige and Skoog medium containing 13.3 μM 6-benzylaminopurine and 500 mg.l-1 malt extract, but their germination was obtained on hormone free-medium. Somatic embryogenesis was induced indirectly from intermediate friable callus initiated at the basal part of the style. Somatic embryos exhibited central procambial cells and were surrounded by a protoderm isolating them from the callus. These embryos had bipolar structure confirmed by the presence of shoot and root apices at cotyledonary stage. The use of cotyledon excised from those embryos failed to regenerate somatic embryos, but gave rise to direct organogenesis in two forms, true buds and protuberances both evolved in shoots after transfer in hormone-free medium. According to histological observations, protuberances are induced from epidermal and subepidermal cells of the cotyledon explant and remain closely attached to their mother tissue even at the shoot stage.

Article Source: Volume 6, Number 2, February 2015 – IJAAR

The Man Who Grew Eyes

Growing nerve tissue and organs is a sci-fi dream. Moheb Costandi met the pioneering researcher who grew eyes and brain cells.

…the Laboratory for Organogenesis and Neurogenesis is growing tissues and organs using an altogether different approach, which doesn’t use scaffolds. Remarkably, they have found that embryonic stem cells can organise themselves into highly complex three-dimensional structures when guided in the right direction. Using a specially developed technique, the team has already coaxed embryonic stem cells to become partial pituitary glands and even bits of brains. Their greatest achievement to date is growing partial embryonic eyes, complete with retinal tissue containing light-sensitive cells, in the hope of developing a new stem cell-based treatment for various diseases that cause blindness.

“We really don’t know where we are going with this,” Yoshiki Sasai, the then director of the lab and Deputy Director of the CDB, told me. “We really are at the final frontier, facing an unknown world.”

Read more about this exciting innovation here.

Human skin stolen from regen med firm?

Human skin stolen from regen med firm?

The AP reports that one Gary Dudek of Pennsylvania is facing criminal charges for allegedly stealing more than $350,000 worth of human skin from a Massachusetts regenerative medicine company that was his former employer. has identified the firm as Organogenesis and reported that Dudek was a sales rep there.  Dudek’s attorney, Eugene Tinari told a TV station that the criminal charges…

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Xenopus gastrulation.

My last and final midterm is for organogenesis! Real fun and interesting stuff… if only I understood it all.

Our prof explained xenopus gastrulation to us, saying it would be easier to visualize in comparison to human or bird gastrulation. In my opinion, human gastrulation was MUCH easier to visualize than this…

Lo and behold, I found a video to try to help me. It’s in French, but luckily, endo, meso and ectoderm are still spelled pretty similarly.

the human body is amazing and yet so STUPID

it lets us to do so many things! it adapts so well! see:
-the immune system
-the HPA axis
-the coagulation cascade
-starling’s law of the heart
-the autonomic nervous system

but then it all goes to hell at the slightest provocation. see:
-autoimmune disorders
-anything to do with the brain. really anything.
-vitamin deficiencies
-all things “idiopathic”
-skin disorders
-hormone imbalances
-heart failure
-organogenesis / pregnancy in general

when things work like they’re supposed to it’s truly a thing of wonder, but when they fail it’s usually in spectacularly dumb ways

Management and controversies of classical Hodgkin lymphoma in pregnancy.

Management and controversies of classical Hodgkin lymphoma in pregnancy.

Br J Haematol. 2015 Feb 13;

Authors: Eyre TA, Lau IJ, Mackillop L, Collins GP

The goal of managing classical Hodgkin lymphoma (cHL) in pregnancy is to obtain good long-term outcomes for both the mother and fetus. Given the excellent outcomes outside of pregnancy, the goal of treatment should remain curative. There remains a tension and debate regarding the timing of chemotherapy, the curative nature of such treatment and the timing of delivery. Moreover, the aim during pregnancy should be to minimize fetal toxicity and optimize perinatal outcomes. The management of cHL within pregnancy was covered within the excellent recent British Committee for Standards in Haematology guidelines, but with necessary brevity. By reviewing the literature over the last 30 years, herein we discuss the options for management during each trimester. Critical organogenesis occurs between 2 and 8 weeks post-conception; during which time the immature fetus is vulnerable to cytotoxic exposure. We discuss the evidence for using ABVD (doxorubicin, bleomycin, vinblastine and dacarbazine) and single agent vinblastine in the first trimester. cHL presenting in pregnancy raises complex and difficult ethical dilemmas that can cause anxiety for patients, families and physicians. Decision-making must be multi-disciplinary and holistic, taking into account the patient’s wishes, psycho-social and religious beliefs and personal circumstances. Clear communication between the haemato-oncologist, medical obstetrician, nurse specialists, midwives and neonatologists is paramount to a successful outcome.

PMID: 25684034 [PubMed - as supplied by publisher]

via pubmed: lymphoma daily