organisms on drugs

I was singing the friggin tune I totally haven’t watched it more than 10 times that Song sings in @cabsim‘s video of them. My mum walks in when the tune reaches the high opera like part. She stared at me, whispered “what the fuck” all wide-eyed, then proceeded to spin on her heel and walk out on me.

Objective: Freak mum out  ☑ Complete

Molecule of the Day: Paracetamol/Acetaminophen

Paracetamol (C8H9NO2), also known as acetaminophen, Tylenol, or Panadol, is a white solid that is slightly soluble in water. It is used as an anti-pyretic (fever-reducing) and analgesic (pain-relieving) agent, and is one of the most common over-the-counter medications worldwide.

Its mechanism is unknown, but it has been proposed that it selectively inhibits the COX-2 enzyme in the body, This decreases the amount of prostaglandins, which are inflammation-inducing and act as pain messengers molecules, to achieve the desired analgesic effects.

While paracetamol has much less severe side effects amongst the non-steroidal anti-inflammatory drugs (NSAIDs), which includes aspirin, overdoses can still occur, with an average lethal dose being 10-15 grams. This is because the body metabolises paracetamol into a toxic compound - NAPQI - which causes liver damage and results in death if it cannot be broken down rapidly enough.

Before paracetamol was discovered and marketed as an analgesic in the late 19th century, acetanilide and phenacetin were the most common pain relievers. However, they tended to have toxic side effects, such as the deprivation of cells of oxygen. Additionally, it was discovered that paracetamol was the active metabolite of those two drugs, and quickly replaced them as analgesics.

Paracetamol is produced industrially by the nitration of phenol, followed by the reduction of the resultant 4-nitrophenol, and then acetylation of the 4-aminophenol with acetic anhydride.

Links:

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Crystallized acetaminophen (or paracetamol for the Brits), empirical formula C8H9NO2, condensed structural formula HOC6H4NHCOCH3, structural formula as shown, drawn by yours truly. There are a variety of systematic and semi-systematic names depending on where you draw the line, but the best I can offer is para-acetylaminophenol, hence para-acetylaminophenol  or para-acetylaminophenolDespite all this, you probably know it as Tylenol, one of the world’s bestselling over-the-counter painkillers and fever reducers.

I crushed up a fairly large amount of Tylenol tablets, washed them with water, in which acetaminophen isn’t very soluble. I then did a hot alcohol (91% isopropanol) extraction on the remaining mass to extract the acetaminophen, and slowly evaporated some of the alcohol to get these crystals. It took a while to get them to look nice like this, and I have much more raw material, but it’s not as pretty as these crystals.


On a side note, I know I’ve been gone for so long! I’m so sorry! Most of my experiments have not been working the way I’ve wanted them to, and I’ve been some ridiculous level of busy lately. I know I say that all the time but just please try to understand. This will all change within the next week and especially after January 1st, once all those darn college applications are done, I’m a free man. I’m trying to finally get some nice organic glassware as well as some other supplies. We’ll just have to keep chugging along till 2017 rolls around and then we can hit the ground running with new experiments. Again, sorry for the consistent delays.

If You Don’t Think That Hogwarts Kids Smuggled In Some Kind Of Strong Ass Wizard Weed Then You Are Fucking Wrong

Like come on, you know there was one brave as fuck kid from Hufflepuff who grew that shit in his backyard and brought it back to school with him for a personal stash. Then planted it in the forbbiden forest or (stupidly) in the greenhouse, but he got caught cause some Slytherins found it and now he’s secretly rich af being the school pot dealer. 

Sincerly, My Tired Mind

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Trump signs three more executive orders — all on crime prevention

  • Trump signed three executive orders Thursday after swearing in Jeff Sessions. They are:
  • Task Force on Crime Reduction and Public Safety
    • In this executive order, Trump declares, “It shall be the policy of the executive branch to reduce crime in America.”
    • In order to do that, the order calls on Sessions to create the Task Force on Crime Reduction and Public Safety
  • Preventing Violence Against Federal, State, Tribal, and Local Law Enforcement Officers
    • This calls on the Department of Justice to “further enhance the protection and safety of Federal, State, tribal and local law enforcement officers,” within the boundaries of the Constitution.
    • It also calls on the DOJ to review whether existing laws are “adequate” to protect law enforcement officers.
  • Enforcing Federal Law with Respect to Transnational Criminal Organizations and Preventing International Trafficking
    • The final executive order says “transnational criminal organizations” — such as drug cartels, human trafficking groups and hackers — have “spread throughout the nation, threatening the safety of the United States and its citizens.”
    • It calls for the executive branch to “strengthen enforcement of Federal law in order to thwart transnational criminal organizations and subsidiary organizations, including criminal gangs, cartels, racketeering organizations, and other groups engaged in illicit activities that present a threat to public safety and national security.” Read more (2/9/17 3:18 PM)
Sherlock, explained
  • Sherlock: hey stranger
  • John: yah
  • Sherlock: follow me
  • John: sure why not
  • Sherlock: it'll be dangerous
  • John: sounds like fun
  • Sherlock: i'll insult you constantly
  • John: i mean so will i so sounds cool
  • Scotland Yard, speaking as a single organism: he's a drug addict sociopath
  • John: sure i definitley believe you guys him? lol no he's trustworthy and would never do something like that
  • experience, common sense, Sherlock's actions, Mycroft: he's a drug addict sociopath
  • John: so
  • experience, common sense, Sherlock's actions, Mycroft: okay do i need to spell this out for you
  • John: yes
  • experience, common sense, Sherlock's actions, Mycroft: fuck it i'm out you're on your own
  • John: gr8
  • Sherlock: hey let's go play mind games pulled straight from The Princess Bride with a psychopath!
  • John: brb saving Sherlock
  • Soo Lin Yao: hey you're a soldier right well can you save me too because I'M BEING FUCKING SHOT AT AND I AM UNARMED HELP
  • John: sure
  • Sherlock: imma gonna go off that way
  • John: nvm brb lol
  • Scotland Yard, speaking as a single organism: she died
  • John: whoops
  • Sherlock: hey you gotta girlfriend
  • Sarah: yes and
  • Sherlock: she's gonna dump you because of me
  • John: so
  • Sarah: you're going to be single until one of you is dead
  • John:
  • Sherlock: hey there's a serial killer on the loose
  • John: this should be fun
  • Sherlock: *pays more attention to moriarty than john*
  • John: this is dangerous
  • Sherlock: *does stupid shit*
  • John: *as a result gets kidnapped*
  • Sherlock: FUCK
  • Moriarty: gotcha bitch
  • Sherlock: *saves john*
  • John: omg what if they think we're gay
  • Fandom: lol too late have you seen the pilot
  • John: shit
  • Irene Adler: *exists*
  • John: bitch please
  • Irene Adler: *looks at sherlock*
  • John: hoo boy
  • Sherlock: i just got a text from Irene
  • John: i know that snake charmer stole you from me
  • Sherlock: what?
  • John: nvm going to go brood
  • Irene Adler: you obviously like sherlock but you say you're not gay so everyone believes it
  • John: yep ain't that great
  • Irene Adler: i'm a lesbian and everyone thinks i'm actively humping his leg
  • John: isn't heteronormativity great oh look at the time gotta run
  • Mycroft: hey she died
  • John: good
  • Irene: *is not dead*
  • Sherlock: hey emotions scare me John thought you'd wanna know
  • John: ok gr8 we can work with this
  • Scotland Yard, speaking as a single organism: hey sherlock you're too good to be believed
  • John: wat have you seen this man he's like the greatest thing ever like his deductive skills are on point and his hair??? omg
  • Scotland Yard, speaking as a single organism: well that's because you're his boyfriend of course you take his side
  • John: i'm not g-
  • Scotland Yard, speaking as a single organism: we're going to arrest him, after we play a long and convoluted game of "play into the villain's hand and force the main character to do something stupid"
  • John: wtf lol really
  • Sherlock: hey mycroft we're gonna need some help
  • Moriarty: *dies in a way that forces sherlock to also die*
  • Sherlock: um hi john
  • John: wtf are you doing on top of a building and is that Moriarty's corpse i'm going up to get you stay still
  • Sherlock: um shit
  • Sherlock: ok
  • Sherlock: i wanted to tell you
  • John: what i'm listening
  • Fandom: *drools*
  • Sherlock: nvm *jumps*
  • John: *spirals into a deep depression, never fully admitting the feelings he had for sherlock to anyone, even himself. gets a boring job. finds a wife in an amount of time that seems suspiciously low. thinks about sholto. tries not to. hallucinates seeing sherlock. is fine. is fine*
  • Sherlock: guess who's back
  • John: BITCH
  • Sherlock: i probably deserve this let me explain
  • John:
  • Sherlock: so-
  • John: YOU LEFT ME
  • Sherlock: *takes hit*
  • John: also i'm getting married
  • Sherlock: great!
  • experience, common sense, Sherlock's actions, Mycroft: sherlock's dying inside
  • John: *gets kidnapped*
  • Sherlock: *pulls him out of literal fire*
  • Irene Adler: amazing how fire reveals our priorities
  • Sherlock: shut up bitch
  • Bomb: is in a train car
  • Sherlock: hey let's go catch it
  • John: ok let's go
  • Sherlock: oh shit i can't defuse bombs
  • John: oh my god i'm going to die, aren't i? oh my gosh i suddenly realize how foolish it was of me to deal with you wtf am i doing you asshole you come back and then you kill us both
  • John: wow symbolism
  • Sherlock: *nearly fails, is dramatic, tries to figure out a way to talk to John, also fails, gives up*
  • John: you are the best and wisest man i have ever known
  • Sherlock: well fuck I found the off switch
  • experience, common sense, Sherlock's actions, Mycroft: holy shit
  • Sherlock: *laughs*
  • John:
  • John:
  • Sherlock:
  • John:
  • Irene Adler: lol
  • Ms. Hudson: hey let me tell you about my wedding, which has an odd number of similarities with john's wedding! it's almost as if THE AUTHORS WANT YOU TO SEE SIMILARITIES BETWEEN THEM
  • Fandom: *pulls out notebooks, puts on theorizing goggles*
  • Ms. Hudson: *whispers* my marriage fell apart
  • Mary: marries John, despite that, because she cannot read the script
  • Mary: *is pregnant*
  • Sherlock: *acts like John's groom at the wedding*
  • Sherlock: *lavishly praises John*
  • Sherlock: *leaves early*
  • Sherlock: *literally cries*
  • Sherlock: *is annoyed about losing john*
  • Sherlock: *is more than annoyed about losing john*
  • Sholto: hi
  • Fandom: OMG JOHNLOCK
  • Sholto: fuck i'm out
  • Sherlock: *is high and Generally Unsafe*
  • Mary: wtf we're getting you to a hospital
  • Sherlock: i'm undercover
  • John: bitch please
  • Sherlock: no really
  • Mycroft: is this about magnussen
  • Mycroft: this had better be about magnussen
  • Sherlock: yes
  • Janine: hi i exist
  • Jannine: *is beard*
  • John: OMG OMG OMG PANIC OMG OMG
  • Irene Adler: aaaaaaand round two
  • Mary: shoots Sherlock
  • Fandom: knew it
  • Sherlock: *stays alive*
  • Mind Palace Mycroft: so
  • Sherlock: *is dying*
  • Mind Palace Mycroft: when you were murdered
  • Sherlock: *is dead*
  • Mind Palace Moriarty: YOU'RE LETTING JOHN DOWN LIKE YOU ALWAYS DO YA BITCH lolol what'd we expect you're such a disappointment
  • Sherlock: I'M BACK
  • John: wtf just happened
  • Sherlock: uh nothing
  • John: right
  • Sherlock: oh btw meet me tomorrow at 2
  • John: uh okay
  • Sherlock: *tomorrow at 2* your wife's an assassin
  • John:
  • John: that is the second most surprising thing you have said to me
  • Sherlock: what was the first-
  • John:
  • Sherlock: right
  • Mary: so it's really really complicated
  • Mary: but, basically
  • Mary: i need you guys to shoot Magnussen
  • Sherlock: ok
  • John: ok
  • Sherlock: you're addicted to danger
  • Mary: oh btw john here's my secret identity
  • John: *ignores*
  • Sherlock, fandom: bitch please
  • Sherlock: hey john let's drug everyone and steal mycroft's laptop
  • John, fandom: okay then
  • Sherlock: and then go shoot magnussen
  • John, fandom: okaaaaay i think i get it
  • Sherlock: hey magnussen imma sell you my brother's laptop
  • John, fandom: this is a trap
  • Magnussen: damn right it is
  • Sherlock: oh shit
  • Sherlock: *shoots magnussen*
  • Mycroft: wtf sherlock this is a step too far
  • Mycroft: so instead of letting you rot in prison
  • Mycroft: we're going to send you on a suicide mission to eastern europe
  • Sherlock: oh fuck what have i done
  • Mycroft: oh fuck what have i done
  • Sherlock: okay so john
  • John: yes
  • Sherlock: before i get on this plane, never to be seen again
  • John: yes
  • Sherlock: i just wanted to tell you as my final words
  • John: yes
  • Fandom: *heavy breathing, crossed fingers*
  • Sherlock: sherlock is a girl's name
  • John: *laughs because wtf?*
  • Fandom: *laughs because wtf?*
  • John, Fandom: *is angry*
  • Sherlock: *steps on plane*
  • Moriarty: hey guess what
  • Sherlock: *steps off plane*
  • Pilot: oh COME ON
  • Sherlock: so now that i've lost john again i'm going to get really super high and then try to figure out wtf happened and also you're never going to be sure exactly what is a dream and this is basically just a 1.5 hour advertisement for season 4 which won't come out until the best fanartists have died
  • Fandom: okay
  • Mind Palace John: ur gay
  • Sherlock: no i'm not
  • Mind Palace John: you're a human
  • Sherlock: no i'm not because if i'm a human i can be hurt and -
  • Bride: HEY BITCH GUESS WHAT I DID *shoots in air without aiming as if doing a suicide squad photoshoot*
  • Mind Palace John: we're continuing this conversation later
  • Sherlock: fuck no we ain't
  • Moriarty: hey sherlock go kill yourself
  • Sherlock: gr8
  • Everyone in real life, probably: sherlock wtf are you doing to yourself
  • Sherlock: distraction, that's what
  • Lestrade: you're digging a hole
  • Sherlock: it's a grave, thank you very much
  • Mycroft: do you have a list i need to get you to the hospital
  • Sherlock: not quite sure actually one sec
  • Mycroft: what have i done
  • Sherlock: ok im back
  • John: yay
  • Everyone Else: yay?
  • Sherlock: and there's no way that the actual moriarty's alive
  • Fandom: are you suuuuuure?
  • Sherlock: yas
  • Moffat, Gatiss: ok so you've gotta wait a full year before you get any more episodes
  • Fandom: wtf
  • Fandom court: ok but your punishment for this and the queerbaiting will be an *absolutely staggering* amount of porn being written about you k
  • Moffat, Gatiss: we signed up for this didn't we
  • BONUS ROUND - GAY PILOT
  • Sherlock: *is wearing skinny jeans and just generally is flippant and also the scene at the restaurant because the world will never shut up about that*
  • Fandom: camp gay
  • John: *ignores every single warning thrown at him about Sherlock, shoots people, is indignant about Not Being Sherlock's Date*
  • Fandom: grumpy bisexual
  • Sherlock: *at the restaurant* so i don't like girls
  • Angelo: your date! hey if you guys need co-
  • Sherlock: and i'm technically married to my work but -
  • John: wait i'm not his date slow down
  • Sherlock: look i want to set you down as nicely as possible b/c it's obvious you're crushing on me really hard
  • John: look i'm so deep in the closet i can see narnia so don't even try
  • John: imma stay unattached and shit
  • John: *saves sherlock's life*
  • Sherlock: you know maybe you don't suck as much as every other person in the world ever
  • John: that's sweet because I SAVED YOUR LIFE YOU LITTLE SHIT
  • Subtext: and then they bang