opiate receptors

Science of Male Orgasm Denial

In an update to her popular article The Orgasmic Benefits of Habitual - Male Orgasm Denial, Aislin Acquati explores the biological, psychological and evolutionary reality of routine male orgasm and how limiting them can dramatically improve your intimacy in relationships.

Dominate His Brain Chemicals By Controlling (Harnessing) His Orgasms

Male orgasm denial has numerous benefits, but do you know the chemical reasoning behind them? Endorphins, hormones, neurotransmitters, and neurochemicals (neurochemistry) affect how we ALL think and feel. By controlling your mans orgasms, you can control their brain chemicals and condition (train) them. Without any supervision or domination, men will masturbate and have as many orgasms as they please – which creates chemical chaos as well as undesired Un-Attentive behavior.

What are Endorphins?

Endorphins are a group of hormones that influence emotions and minimize the sensation of pain. They attach to opiate receptors, mostly in the brain. Pain and stress most typically influence endorphins to be released. They operate similarly to codeine and morphine.




Women Can Enjoy Blissful Daily Orgasms – But Men Need To Be Denied

It’s true – Orgasms affect men and women “Differently”.

It is empowering to know that you can relish multiple orgasms on a daily basis while withholding them from your Virile Lover. Knowing there are hormonal reasons behind the science, (making him stronger and healthier), is just icing on the cake!

Endorphins and Other Chemicals That Control The Brain and Motivation

1. Endorphins: Natural painkillers that are extremely more potent than morphine – producing feelings of euphoria.

2.  Oxytocin - The Love , Cuddle and Bonding Hormone: Decreases abstract cravings – diminishes stress  – keeps couples together – provokes passion, devotion, attachment and deep feelings of fondness – strengthens sexual receptivity.

Normal/Raised Levels of Oxytocin: Devotion – a feeling of being connected – feeling protective and responsible – health benefits (reduces blood pressure and speeds up wound healing) – intense feeling of attachment – increases sexual alertness –   less addictions and cravings – positive viewpoint and attentiveness.
Low Levels of Oxytocin: Depression – low sex drive – reduced, indifferent or no feelings of of attachment, connection or devotion – poor or no feelings of protection and responsibility for another person – weakened immune system.

3. Dopamine, The “I have to have it” Neurochemical:

Normal/Slightly Raised Levels of Dopamine: Generates feelings of happiness – healthy sex drive – joy in completing tasks – motivated  – optimistic outlook – postitive feelings toward others – rational decisions – yearning to bond with others.
Low Levels of Dopamine: Ambitionless – despair – displeasure – idleness – impaired judgement – low sex drive – remorseless of own behavior – social anxiety – unable to feel love.

4. Serotonin (a neurotransmitter):

Too Much Serotonin: Anxiety – gastrointestinal disorders – insomnia – sexual malfunction.
Not Enough Serotonin: Decrease or increase in appetite – insomnia – isolation – loss of libid – low self confidence – ongoing saddness – over sensitive –– sore joints and muscles – stoamch pain.

5. Testosterone ( a hormone):

Low Testosterone:  Anger decreased motivation and self esteemdecreased muscle mass and increased body fat – depression – difficulty with concentration and memory – fatigue – low sex drive – irritability .

6. Prolactin (a hormone): After orgasm, it may make one feel sexually satisified and repress dopamine.

Excess Levels of Prolactin: Depression – diminished interest in bonding with others – – lowered testosterone levels – low sex drive – depression – infertility – irritibility – lethargy – pessimistic outlook – weight gain.

This is how it works:

Men experience a rush of dopamine during orgasm that puts them in a state of ecstasy. However – in most men – the blissful feeling disappears after 5-10 seconds. Interestingly, the surge of dopamine triggers an almost simultaneous burst of prolactin that causes dopamine levels to plummet. The result is a dopamine level that is much lower than it was before sexual arousal began. In addition, an above normal level of prolactin continues for up to two weeks.

Woman receive a peak in dopamine during orgasm, but (unlike in males) it doesn’t crash drastically; rather, it subsides in a gradual sequence of steps. Prolactin also increases to a level slightly above normal (upon feminine climax) – staying there briefly while dopamine levels gently return to their normal levels. Another recent discovery is that Women’s dopamine levels vary throughout the month based on their menstrual cycle.

You may be wondering what all this means. It means that…

1. Male Orgasms Are Addicting

Have you heard a song about love or sex being a drug or addictive and wondered if there were any truth to it? Consider the following song lyrics:

“Oh oh catch that buzz
Love is the drug I’m thinking of
Oh oh can’t you see
Love is the drug for me” – Love Is The Drug by Roxy Music

“The perfect drug | the perfect drug | the perfect drug
You make me hard when I’m all soft inside
I see the truth when I’m all stupid-eyed
The arrow goes straight through my heart
Without you everything just falls apart” – The Perfect Drug by Nine Inch Nails

Well – male ejaculations can definitely be addicting due to dopamine, the “I have to have it” neurochemical. When comparing brain scans, Gurt Hoistege, a Dutch Scientist found an astounding resemblance of male orgasm to shooting heroin.

After they researched rats, scientists in Mexico City pointed out that repeated ejaculations can very closely imitate the effects of abusing drugs.

2. Men Experience a Post-Orgasm Hangover

After orgasm, men experience a hormonal hangover similar to an opiate or cocaine withdrawal due to low dopamine and high prolactin. Dopamine levels fall while prolactin levels rise after orgasm and after stopping an opiate or cocaine. It takes two weeks for prolactin levels to normalize after stopping cocaine.

During a post-orgasm “hormonal hangover,” men may look for new highs, such as drinking alcohol – eating sweets – new sex partners – porn – and drugs, to boost their dopamine levels. They may also feel disconnected from their partner – experience depression – or become lethargic.

When dopamine levels are constantly bursting up and plummeting down due to uncontrolled orgasms, it can wreak havoc on relationships. Your relationships could feel like a never-ending roller coaster ride full of highs and lows with no middle ground.

3. Too Many Orgasm Lead Him To Cheat

Once plighted, no men would go whoring.
They’d stay with the one they adore,
If women were half as alluring
After the act as before – Ancient Greek Anthology Poem

Or we could phrase it:

Once married, no men would be cheaters.
They’d be faithful to the one they adore, rather than acting a whore
If women stayed half as enticing After orgasm as before

In any case – long before our time, humans knew that men cheated on their wives because they were not as appealing after sex! Once again, dopamine is the chemical responsible for men choosing to act in a way we ladies don’t like.

Scientists found that after male rats partake in a frenzy of sexual intercourse, they will lose interest in that female. However, if a new female comes along, the male will have sex with her. They linked the phenomon of mate fatigue to dopamine. When a male rat has intercourse repeatedly with the same female, dopamine levels continue to drop. When a fresh potential mate arrives, a surge of dopamine follows.

So – to keep your men feeling you are the most beautiful woman on earth with a World Class “Sacred” Vagina – you must harness and resolutely control their orgasms!

4. Repeated Orgasms Decrease His Sex Desire

Male rats also experience a decrease in testosterone receptor for up to seven days within their reward circuit. Hormones, such as testosterone, and neurochemicals dock on the nerve cells, along with receptors. In this instance, fewer receptors equals less reactivity to circulating testosterone. As a result, the reward system releases less dopamine.

The first problem is that low testosterone, or a reduced sensitivity to it, can cause anger and irritation. No woman wants to give a man an orgasm and then receive annoyance in return!

Not only that – you don’t want to “Allow” your man to Ejaculate if the undesirable psychological result is a lowered sex drive. This brings us to the second problem, which is the fact that endorphin and serotonin levels go up - in the reward system of the sexually satisfied rats. Endorphins and serotonin are both neurochemicals that can produce happiness, but when they are in this part of the limbic system, they bring things to a stop rather than only generating good feelings. Think of it this way: Antidepressants, such as Zoloft – Prozac – and Lexapro, that increase serotonin and narcotics, such as Vicodin – Percocet – and Methadone that imitate endorphins, can cause sexual side effects. When neurochemicals diminish the reward circuit for a period of time, complications in your intimate relationship – both physically and emotionally – can and will occur.

If you want your guy to have a low sex drive for several days to a week, allow them to have orgasms whenever they chooses – or encourage them to take an antidepressant or opiate! If you just thought or yelled – HELL NO – Then we’re on the same page.

5. Uncontrolled Orgasms Make Him Fall Out of Love

In her book “Cupid’s Poisoned Arrow: From Habit to Harmony in Sexual Relationships,Marnia Robinson points out the following: As a cure for love, the Roman Poet Ovid cynically recommends pursuing orgasm until it results in disinterest.

cruel Love presses your neck beneath his foot?…
Go, and enjoy your girl, any time, nothing’s forbidden:
let her steal away your nights and days.
Seek loathing for your sickness: and let loathing end it.
Now, too, when you believe you could be free, stay on,
till you’re quite overwhelmed, and abundance destroys love,
and disgusted you’ve no pleasure in her house. – Or Sate Yourself With Her by Ovid

Due to a dopamine drop and prolactin burst after orgasm, “eventually a man can develop feelings of indifference or slight repulsion for his sexual partner,” according to Taoist Secrets of Love by Mantak Chia.

Oxytocin is the chemical that keeps love alive, and Ladies can magically increase this baseline oxytocin level in their lives by cuddling – hugging – holding hands – massaging as well as sexually “Edging” their males.

The Cure is Simple

The cure for the chemical chaos that uncontrolled orgasms produce in males is simple – The Cure is Orgasm Denial. .

Are you ready to dominate and ultimately control your mans brain chemicals – do you want to train him to respond to you with any “Conditioned Response” You Desire ? or have you already learned to do so? Share your experience with femdom relationships and male orgasm denial (Karezza) by visiting the Tumblr Site Below.

To learn more about Male Orgasm Denial, Natural Subjugation and Devotional Male Response – read “The Orgasmic Benefits of Male Orgasm Denial.”

Brigitte Kieffer (b. 1958) is a French molecular neurobiologist, working mostly with opiate receptors. She is an international expert in the field, and her research has significantly added to the understanding of how the brain processes pain and drug addiction.

She was a professor at the University of Strasbourg, and went on to do research in several institutes throughout France and the United States. Her research led to the development of a new analgesic medicine, used as a treatment for addiction. In 2013 she became a member of the French Academy of Sciences, and won several medals offered by the institution.

Walking the Tightrope

Scully and Ethan are no longer together. What about Scully and Mulder? Post Jersey Devil and probably the final part in this series. Thanks for coming along for the ride.

Tagging @today-in-fic

Need to catch up? Read Part One  Part Two  Part Three Part Four Part Five

Part Six

Apparently, having a life with a guy like Rob was not a realistic life goal. But, bailing out her errant partner was. Shouting him breakfast was. Chasing after beast-women in the New Jersey forest was. Going to the Smithsonian was. But clearly, riding him in the back of his car at the far corner of the museum car park was going to be the pinnacle of her life because it felt so, so…fucking good.

              She slid up and down on him, every ridge sparking electrical impulses inside her skin. This was unlike anything she’d experienced before. He was so hard. She was so wet. This was primal. The very epitome of the case they’d just finished. Beast man and beast woman. Instinct. She let her head fall back, let him rub his thumb over her clit, let him nuzzle at her nipples, let him turn her from rational scientist to a series of guttural and breathy moans. Pleasure meant everything. Base need compelled her every move. Everything else was background noise. Until he moaned her name and reality set in.

              “What the hell are we doing, Mulder?” she said, huffing the hair out of her eyes, while he kneaded her breasts under her open shirt. She’d lost track of where her bra went. She knew her panties were ripped and trapped around one thigh. Her trousers were hanging over the back of the passenger seat and his belt buckle was scratching at her lower back in a circular motion, no doubt leaving a mark.

              “Eight million years out of Africa, Scully, and I’m pretty sure that rudimentary human behaviour is still much the same. Eat, drink, fuck.” He bucked up and groaned.

              “You didn’t even buy me dinner.” She bent down and kissed him hard, sucking on the lower lip as he ground into her, lighting her clit on fire. “Fuck, Mulder. Fuck me, Mulder. Fuck me so hard, Mulder.”

              He chuckled into her hair and upped his game. She held her breath and waited for the pressure to burst and when it did she cried out, digging her nails into his chest and scraping them downwards. He yelped and she opened her eyes to see his head fall back and his eyes roll in pain.

              “Shit! I’m sorry.” She patted his bandage back down and he grimaced.

              “S’okay,” he said, his voice rasping over his teeth. “Endorphins are solid pain relief, Scully.” He moved his hips and she rolled her own to the rhythm he set. His breathing ramped up and he gripped her hips, holding her in place as he let go. The guttural noise he made was about the most base and erotic thing she’d ever heardand she looked up at the ceiling of the car wondering why it had taken her this long to want to hear it. Her own breathing calmed and they stayed, joined in the silence, for a long while.

              “Peptides activate the body’s opiate receptors causing an analgesic effect,” she said, twisting off him and feeling the cramps in her legs as she shifted her weight to find her clothes.

              “I love it when you talk dirty, Dr Scully.”

              She zipped herself up and looked at him, hair askew, stubble, shirt unbuttoned. He was an unkempt mess but he was so fucking hot. “Seriously, what are we doing?”

              He got out of the back and stood outside, stretching. She could barely see him in the dim glow of the car park light but she knew he would be cricking his head from side to side, hands on hips, pushing his lips out. When he got back in, he turned to her and smiled. It wasn’t the dazzling, charmer. It wasn’t the guilty half-smile. It wasn’t the I-wanna-fuck-you or I-wanna-fuck-you-over smile. It was humble, grateful almost. Like he might actually be a normal human being. And that probably meant trouble.

              “Scully, I…I’m not good at this stuff. I blow hot and cold. I never know when to open up and when to shut up. I’m kind of an all or nothing guy. I hope you know that by now. I don’t want to hurt you. I think you’re an amazing person, I want you by my side as my partner, that I know without doubt. As for anything else, I can’t make promises. My work is everything.”

              His thigh was solid under her touch, his muscle flexing. “I appreciate your honesty, Mulder. I guess I’m just really surprised at my own behaviour. I’ve never been like this.”

              “Like what?” he said, his voice thick and warm and inviting.

              She chuffed. “I don’t know what the right word is. I guess I feel disconnected to the person I used to be.”

              “To the person who dated Ethan? The person who thought she could have a life?”

Her head flopped back against the seat rest. “Who is that person? Was I ever that person? Do I want to be that person? It seems so unattainable, so…”

“Unlikely?” he offered.

Turning to face him, she felt tears pricking at her eyes. “Maybe.”

“What do you want, Scully? What do you really want?” He took her hand in his and massaged her fingers.

She sucked in the emotion, steadied herself. “I want to do good work. I want to expose the truth. I want that life now. Wherever it takes us. Whatever happens.”

He leant forward and kissed her. “Then we want the same thing.”

Suzuya’s loss of pain theory


but seriously why havent you read the manga yet!

So the first time this thought came to mind was during juuzou’s battle with the twin sisters. During that time he got his stomach slit.

even after that he kept on fighting. All those sick moves, defeated the sisters and his split stomach did not hinder him. On a physical level, yes they did because his insides were probably dangling out, but not on the pain scale. After the battle he just casually stitch himself like no big deal

i didn’t know much then so i placed the thought aside but something like this again happened during the owl battle when suzuya got his right leg cut off

Firstly he didn’t even know his leg got cut off and then he told shinohara that it didn’t hurt. But then we have shinohara getting his right leg cut off. Screams and pain.

Well it could’ve been due to his torturous past that he didn’t feel pain or had a high endurance level. But he is still human and pain is pain. Getting your leg chopped off is probably much painful than needles etc. And im pretty sure Shinohara had had physical injuries before but look at the blood probably coming out of his mouth. On the other hand..jouuzou not even a flinch

Then i did a bit research 

“Congenital insensitivity to pain
Congenital insensitivity to pain is considered a form of peripheral neuropathy because it affects the peripheral nervous system, which connects the brain and spinal cord to muscles and to cells that detect sensations such as touch, smell, and pain.”

Dissociated sensory loss

“They found that opiates(endorphins) interact with specialized receptors in cells that are primarily massed in the brain and spinal cord. When opiates enter these receptors, they hinder or block the cell’s transmission of pain signals.”


  1. Stress and pain (recurrently) are the two most common factors leading to the release of endorphins. Excessive release of endorphins can cause Loss of pain.
  2. spinal cord infection and fracture can also be a cause to loss of pain

we’re all familiar with jouuzou’s past 

and of course this one

if you’re thinking that kanaki was tortured too then note that kaneki was tortured for aprox 10 days while suzuya was for like 3-5 years (i don’t know exactly)

i’m no neurologist but my theory is that Suzuya Jouuzou has lost his ability to feel physical pain after being tortured for what like 3-5 years. Though he still has sense of touch.

what do you guys think?

Interview with Dr David Levy

*The scene takes place in a beautiful garden filled with purple flowers, a small fountain, trees, and a stained glass display of a bridge. A man enters in a loose-fitting linen shirt and pants, sandals, an orange foam visor, and sunglasses. Lo and behold, the man is the famous neurosurgeon Dr. David Levy*

The conversation starts with Dr. Levy asking me about my academic background, family, relationships with others, spiritual journey and obstacles, and career goals. 

Even with a strong background in medicine, academia, and science, he makes clear the priority God plays in his everyday perspective and interactions with others.

Me: Dr. Levy, having been raised with religion and a strong academic background, how do you resolve conflicts between faith and science? For instance, it is stated in Hebrews 11:1 “Now faith is the substance of things hoped for, the evidence of things not seen.” Everything in science is based on proof, reproducibility, and evidence. How does this shape your view of God?

Dr Levy: Everyone has a bias, an idea of what they want to be true. As such, even truth is not devoid of bias. The human brain functions to minimize pain and maximize pleasure. Scientists get pleasure from their discoveries. To acknowledge God takes away from the glory/pleasure held by a scientist and their work. In addition, to acknowledge God in a scientific community can cost you a job or promotion. There are many reasons scientists would find it convenient not to believe in God.  

Many arguments against God go like this: It is convenient for believers in God to use God for anything science doesn’t know or can’t do. Since science is moving so fast, eventually we will discover the answer to everything.
But this belief in science requires as much or more faith. It takes faith to believe that science will discover how to create something from nothing and then create life that reproduces itself. We have to question, how much of the universe do we actually know? How much faith does it take to assume that we will know it all? 

We can look at the degeneration of hip replacements after 10-20 years and it takes a huge step of faith to believe the natural design is insufficient and the designer didn’t know what he was doing.  We are prideful in the face of constant change and circumstances to believe that all the required conditions for life happen solely by chance. We need faith either way: To believe no God is needed, or to believe God is integral to the universe. We get to choose. Of course, your brain will bend the evidence toward your bias, the way you want it to be; the most convenient for you presently.

Me: In Ramachandran’s book “Phantoms in the Brain” he discusses the correlation between temporal lobe epilepsy and feelings of being God. In Candace Pert’s book “Molecules of Emotion” she discusses the role of opiate receptors in the limbic system, and our ability to experience euphoria in balance with decision making. If Ramachandran suggests God exists in the temporal lobes and Candace Pert suggests God exists in the frontal cortex, where do you think God exists in the brain?

Dr Levy: There are a number of neural pathways that give you the perception of God. Neurologically God becomes real like any other experience, building upon what you have already known or imagined. These pathways get reinforced and rewired with both positive and negative experiences. If you think God is angry, it will directly impact your health and reinforce a self-critical reflection of God’s image. The brain has the power to influence behavior and is guided by the biases we [conveniently] want to see as truth. God exists outside the brain and to restrict him to existing in a single brain region denies the relational aspect between us and God.

Me: What role do you see robotics playing in neurosurgery as technology continues to advance?

Dr Levy: I see the integration of robotics as a slow progression that may take anywhere from 10-20 years. There are simply so many subtleties to consider in neurosurgery.

Me: What is the greatest challenge you have had to overcome?

Dr Levy: The fear of what other people think. The higher up you go, the more you have to lose. Given an insecure environment and upbringing, you learn to focus on making people like you. To say you don’t agree with the norms in science and medicine risks that.

Me: What is the greatest breakthrough in neuroscience that you have witnessed?

Dr Levy: Aneurysm flow diverters. The devices completely changed treatment and allowed a progression away from open skull surgery to endovascular neurosurgery [which is significantly less invasive and far lowers the risk of infection].

Me: What do you enjoy most about your profession?

Dr Levy: I find the technical, exact nature of it appealing, as well as the interaction with people. You are able to encourage them, help them along their journey, and can extend their life. I can’t make it better unless I ask about their relationships with their self, with others, and with God [as feelings of regret, resentment, negative self-talk, and pain directly affect their quality of life and health].

Me: What are you currently working on?

Dr Levy: I’ve been doing a lot of Christian meditation, integrating the word of God into breathing. You can download them on DrDLevy.com

At this point, I had to meet up with a friend, but Dr. Levy was gracious enough to let me take a picture with him and offer his guidance in my spiritual journey.

Candace Pert (1946-2013) was a pharmacologist and neuroscientist, most famous for discovering the opiate receptor – the cellular binding site for endorphins in the brain. She also gained significant international reputation in the field of pharmacology, having published over 250 scientific articles on neuropeptides and their role in the immune system.

After gaining her PhD from Johns Hopkins University, she conducted important research at the National Institute for Mental Health for several years. For this work she is considered a pioneer of mind-body medicine. In 1983 she became the only female chief at NIMH, as Chief of the Section of Brain Biochemistry. Her contributions to the medical field include treatments for psoriasis, Alzheimer’s and AIDS.

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