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Surat al-Fatihah – Chapter One of the Quran

بِسْمِ اللَّهِ الرَّحْمَنِ الرَّحِيمِ (1) الْحَمْدُ لِلَّهِ رَبِّ الْعَالَمِينَ (2) الرَّحْمَنِ الرَّحِيمِ (3) مَالِكِ يَوْمِ الدِّينِ (4) إِيَّاكَ نَعْبُدُ وَإِيَّاكَ نَسْتَعِينُ (5) اهْدِنَا الصِّرَاطَ الْمُسْتَقِيمَ (6) صِرَاطَ الَّذِينَ أَنْعَمْتَ عَلَيْهِمْ غَيْرِ الْمَغْضُوبِ عَلَيْهِمْ وَلَا الضَّالِّينَ (7)

In the name of GOD, Most Gracious, Most Merciful. Praise be to GOD, Lord of the universe. Most Gracious, Most Merciful. Master of the Day of Judgment. You alone we worship; You alone we ask for help. Guide us in the right path: the path of those whom You blessed; not of those who have deserved wrath, nor of the strayers.

Originally found on: neverwithoutislam

(Image caption: Inflammation in an MS lesion prompts the blood-brain barrier to boost netrin-1 (green) to limit neuronal damage)

Researchers Show How Blood-Brain Barrier Is Maintained

The brain is a privileged organ in the body. So vital to life, the brain is protected from alterations elsewhere in the body by a highly regulated gateway known as the blood-brain barrier, which allows only selected molecules to pass through.

In certain diseases, however, such as multiple sclerosis, the barrier can be improperly breached. These “leaks” can allow immune cells and inflammatory molecules to pass through, causing inflammation that leads to neuronal damage.

In a new study, researchers have made insights into how the blood-brain barrier, or BBB, is maintained, identifying a protein key to the process. Delivering this protein to mice with the rodent equivalent of MS improved their symptoms.

The research, led by the University of Pennsylvania’s Jorge Ivan Alvarez and Cornelia Podjaski of McGill University and Alexandre Prat of the University of Montreal, appears in the journal Brain.

Alvarez is an assistant professor in Penn’s School of Veterinary Medicine. He conducted the study with Podjaski and Prat and colleagues from McGill University and from the University of Montreal, where he completed a postdoctoral fellowship under the direction of Prat. Podjaski is currently a researcher with New Nordic Inc. Prat is a professor in the University of Montreal’s Faculty of Medicine and directs the Neuroimmunology Laboratory at the Centre Hospitalier de l’Université de Montréal Research Centre.

In 2011, Alvarez and Prat published a study in Science that showed that the protein sonic hedgehog, or Shh, is secreted by central nervous system cells called astrocytes and plays a key role in blood-brain barrier maintenance, in part by preventing immune cells from entering the brain.

But the researchers still didn’t have a complete picture of the signaling events downstream of Shh that mediated this effect. To learn more, they first used human cells in culture from the blood-brain barrier, called endothelial cells. They found that applying Shh to the cells caused levels of a protein called netrin-1 to rise.

In mice bred to lack the molecular receptor for Shh, netrin-1 expression was reduced, indicating that netrin-1 expression depends on Shh.

“Netrins are best known to play a role in guiding the direction of axon growth as well as morphogenesis and tissue formation,” Alvarez said. “But our work suggested a new role for netrin-1 in the blood brain barrier.”

Curious as to whether this might influence MS, they examined BBB cells from the brains of people who had died from the disease. Normal tissue from these individuals contained low levels of netrin-1, while the diseased lesions in the brain had higher levels. The researchers found similar results in a mouse model of MS called experimental autoimmune encephalomyelitis, or EAE.

Next, the team directly measured netrin-1’s effect on BBB permeability by labeling tracer molecules and found that netrin-1 significantly reduced the movement of molecules across cultures of human BBB endothelial cells. Further experiments showed that netrin regulates this process by promoting the expression of the so-called “tight junction” proteins, which are located between BBB endothelial cells and are responsible for controlling barrier function. The team also found that, when in an environment rife with inflammatory signaling molecules, which would normally compromise the integrity of the BBB, netrin-1 had a counteracting effect, preventing disruption to the BBB.

“In mice bred to lack netrin-1, we observed that proteins normally found in the blood accumulated in the animals’ brain, another sign that netrin-1 ensured the integrity of the BBB,” Podjaski said.

Armed with these findings suggesting netrin-1 protects the BBB, the team tested the potential of netrin-1 in ameliorating EAE symptoms, which are similar to those of people with MS.

“By administering netrin-1 to mice before the EAE disease was induced, we found that animals had less severe disease, delayed disease onset, fewer lesions in their brain, fewer markers of inflammation and better maintenance of body weight compared to mice given a sham treatment,” Podjaski said.

“In mice, we found the disease outcome is better when they’re treated with netrin-1, even when delivered after disease processes had begun,” Alvarez said. “And all those observations held up in vitro as well.”

Moving forward, the researchers hope to further elucidate the pathway through which Shh and netrin-1 operate, with an aim toward finding more effective ways to uphold the barrier and perhaps one day treat diseases like MS.

“We now know that Sonic is above netrin-1 in the signaling pathway, but what else is Sonic hedgehog doing?” Prat said. “We need to complete the puzzle with Sonic first to give us better therapeutic strategies.”

#CledePeauBeaute’s Radiant Powder Foundation in action.

Here’s my take on it so far:
#1 It lasts ok if you’re not working up a sweat. If you are, this will break down.
#2 It does not oxidise but it will not really control shine either. So I don’t recommend it for very oily skins.
#3 It doesn’t emphasize flakes but it doesn’t have any hydrating properties. There are times my face felt quite dry wearing just this for hours.
#4 It lasts much better over BB creams and light foundations than over primer alone.
#5 It has medium coverage, doesn’t grab and look cakey over concealer and foundation, and gives a semi-matte glow, so it’s actually perfect as a setting powder if you need a flawless but “natural” coverage.

I recommend it if:
- you have normal or slightly combination skin and want a convenient powder foundation that’s not too matte.
- you are a bit oily or dry and only want to use this as a perfecting setting powder over a liquid foundation suited to your skin type, or don’t mind using a setting/sealing spray over it.
- you are an artist looking for a powder that looks very naturally radiant for a shoot and don’t need it to last more than a few hours.

Of course, your budget has to allow for the $220 upfront price-tag as well.

Makeup colors: exactly what was listed in the previous IG post!
#makeup #fotd #review #foundation #luxemakeup #cledepeausg #cosmetics #beautytip #sg #bblogger #powder #ysl #babydoll

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Tiger Lily Foxtail | Baby #2 of the Foxtail 100 Baby Rainbowcy

Night Owl ♦ Virtuoso

CC:
SkinHairEyelashesNose maskBlush N8LipsDressSliders

Father:
Scorch Torch by simsandgiggles

TOU:
Don’t claim her as your own or re-upload her anywhere. Differently from my other sims, I don’t mind you changing their facial features. Just don’t be a berryhole. I also love to be tagged when you use her.

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