Exogenous microRNAs in maternal food pass through placenta, regulate fetal gene expression

In a new study published in the Protein & Cell, Chen-Yu Zhang’s group at Nanjing University reports that small non-coding RNAs in maternal food can transfer through placenta to regulate fetal gene expression.

MicroRNAs (miRNA) are a class of noncoding RNAs with lengths of approximately 22 nucleotides that bind to target messenger RNAs to inhibit protein translation. In previous studies, the same group has found that plant miRNAs can enter into the host blood and tissues via the route of food-intake. The food-derived exogenous miRNAs are absorbed, packaged into microvesical (MV) and then secreted into circulation by cells of animal GI tract. More importantly, once inside the host, the food-derived exogenous miRNAs can regulate host physiology by regulating host “target” genes in the cross-kingdom manner. In support of this new concept, they have also found a plant microRNA, MIR2911, which is enriched in honeysuckle, directly targets influenza A viruses (IAV) including H1N1, H5N1 and H7N9. Drinking of honeysuckle soup can prevent IAV infection and reduce H5N1-induced mice death.

Here, they report another surprising finding that exogenous plant miRNAs and artificial synthetic small influence RNAs (siRNAs) can transfer through the placenta and directly regulate fetus gene expression.

Diagram of microRNA. Based on [1], [2], [3], the wikipedia article, and various other sources. Kelvinsong - Own work

What I Wore | In Full Bloom
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WhatIWore: We had the most beautiful weekend here in Bloomington! On Saturday we had donuts at home, went to the farmer’s market and then spent the entire day hanging out in our friend’s backyard in the sunshine. I am in LOVE with this new dress (so much so I’m thinking of getting it in another color way) because it makes me feel like me

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When you don’t realise how cold it is and end up wearing a non-maternity coat that doesn’t fit (but was in the boot)… Also, can I just point out that my whole outfit is an atrocious mix? Fashion icon in the making! Oh, and I would’ve taken a better photo but it seems this was all I could fit of me in one picture thanks to my bump. 🙈 xx

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A top bun and a baby in my belly. Also, nothing fits these days. 😩 Any recommendations for cute maternity or non maternity clothing?

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Happy New Year! A lot has been happening around these parts and I’ve really missed [over]sharing with y'all. I hope that everyone had a happy holiday season. 

Whew. The above photo was taken yesterday morning– the beginning of week 29. And yes, I need to clean my mirror. That belly has exploded and I am well into stretching out any of the non-maternity clothes that I can still squeeze myself into. Thank goodness Santa & the birthday fairy heeded my call and brought me a few pairs of size up workout pants for Christmas. I have a feeling that will be a big part of my wardrobe towards the end of my pregnancy. 

I had a big checkup on New Years Eve. Glucose test, an u/s to check baby’s size, a visit with my favorite doc, and then a not so fun shot as I’m Rh-negative. Thankfully, I passed the glucose test literally by the skin of my teeth (we’re talking ONE DAMN POINT) and all is well with our little nugget. She did have one small issue that we discovered during our anatomy ultrasound @ 18 weeks but, thank God, it has since resolved itself. Healthy baby as far as we know. What a blessing to be able to say that. 

This child has apparently hit her growth spurt and is measuring almost 10 days ahead of where she should be (saying this in hopes that we have a healthy, chunky little girl not in hopes that she comes early at all). I realize this is only according to the doctor’s calculations (which put her at 3.6 lbs), but I can only assume that she’ll be a hearty nugget when the ultrasound tech exclaims “Holy cow- look at that femur! I’ve never seen anything like it!” Oh, and she’s still breech. I have been told to not worry about this until week 36- but I need to start preparing myself for the possibility that she might not decide to come naturally. I’m on the fence about trying an ECV so I’d love to hear from anyone that’s had experience [of any kind] in this department. 

FINALLY sweet baby decided to let us catch a QUICK glimpse of her face (thanks to the orange glucose drink I imagine). Oh, you guys- her lips and those cheeks! I can’t stop staring at her little features. I imagine that our desire to finally meet her will only increase as the weeks go on, but something about seeing her little face makes me giddy with excitement. 

Much to the avail of anyone over 65, I’m still wearing heels. The only issues with my feet thus far has come from going barefoot as my heels are starting to feel the impact of my (baby’s) weight gain. 

Thanks to 10 days off of work, we have nearly finished up baby H’s nursery. All that we are waiting for now is the delivery of her rocker (that I ordered way back in October). I always made fun of those folks that said they really enjoyed going to sit in the nursery before baby’s arrival- until I realized that I do that very same thing myself these days. The little room is just so serene and neutral. I can’t wait to share photos with y'all once it’s finally complete! 

Windsor is starting to get a little territorial with the baby’s room so I have taken to closing the nursery door during the day. Momma only needs to clean up so many messes during the day if you know what I mean. I’m not concerned about W bonding with Baby once she arrives but Windsor is not an idiot an clearly understands that something is about to change given the time we’ve been spending getting the room ready.

A few other tidbits over the past couple of weeks…

  • Weight gain thus far: 18 pounds
  • Cravings: chocolate milkshakes, red meat, avocado salad, hint water (particularly the mango/grapefruit and the blackberry)
  • Sleep: Ha. I toss and turn for a good majority of the night. Thank God for a king sized bed. 
  • I feel a little like a Shar-Pei these days. I’ll let you figure that one out for yourself. 
  • Discomfort: still in my right abdomen (directly related to the position of her head and giant cheeks), heels, sporadic charlie horse in both legs in the middle of the night

I do have some new “favorite things” to share later with you all. Not that I’m a maternity expert by any stretch of the imagination but just some goodies that I’ve come to love. Stay tuned as this post is already far too long. Sorry about that- but I told you I had a lot to share ;)


What I Wore | Vintage Coat

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WhatIWore: Morning everyone! Here’s what I wore earlier in the week for a coffee shop session and later for errands. I’ll admit I’m rather happy about winding down with the blog for a while - between the post election fall out, the holidays and being closer and closer to my due date, my heart just isn’t as into blogging these days. And that’s ok! I have a goal of shooting another 4-5 outfit posts, plus some inspiration boards, and photos of my daughter’s nursery and then… it’s maternity leave baby! Which all new moms and dads know is more like boot camp than a spa day… but bring it on! I’m ready to meet this little lady!

When: November 29, 2016

Shades: Karen Walker
Sweater: Motherhood Maternity
Coat: Vintage
Jeans: Jeans: AG ‘Stilt’, (non maternity here
Booties: Rag and Bone

Where: Coffee Shop, Grocery

When I got dressed this morning I thought back to one of my favorite outfits of all time (from three years ago!) and did my best to make it work for pregnancy. This bump feels more like a basketball and even some of my maternity pieces are getting tight! 

I don’t wear this coat/jacket often, but it’s a vintage piece I’ll never let go of. The precise matching of the stripes just screams quality - it’s not easy to cut or sew something so geometric! 

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After ordering and returning about 15 different maternity items from Old Navy, Gap, LOFT, etc. I finally decided to try Le Tote on the suggestion of another mom.  I love the idea of just renting clothes and sending them back when I’m done with them - and their stuff is really cute! (The picture above is what was included in my first box). 

If you haven’t heard of Le Tote before, it’s sort of a combination between Stitch Fix and Rent the Runway - you get a box of clothing styled for you for a monthly fee ($59 for non-maternity, $69 for maternity).  They will tell you in advance what they picked for you, and you can switch out the items for something else if you don’t like them.  Then you can wear the clothes as much as you want, and for as long as you want, before returning (there is no limit to how many boxes you can receive in a month).  And if you want to purchase one of the items, you will be able to buy it for a discount off of retail.  I think the price is a bit high since you’re just paying that for renting, but at least for me right now, it’s perfect - I don’t really want/need to own these maternity clothes forever anyways.

(If you’d like to get your first box for free - i.e. they’ll wave the $59 monthly fee - you can use this link).

What I Wore | Tis the Season

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WhatIWore: Can you believe we’re under a month away from Christmas!?! Where did November go? I’m not complaining, especially not this year - I’m in countdown mode for our due date! 

When: November 27, 2016

Shades: Karen Walker
Scarf: J.Crew Factory (similar options below)
Coat: J.Crew (older style, similar here)
Turtleneck (regular sizes): Old Navy
Jeans: Jeans: AG ‘Stilt’, (non maternity here
Boots: gift of Rockport, from last fall (similar under $100)

Where: Lunch with my guys

See also: Another neutral but Christmasy outfit idea here

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