Neurotoxicity of chemotherapy drugs

Chemotherapy is one of the primary treatments for cancer. However, one of the most disturbing findings of recent studies of cancer survivors is the apparent prevalence of chemotherapy-associated adverse neurological effects, including vascular complications, seizures, mood disorders, cognitive dysfunctions, and peripheral neuropathies. In addition, chemotherapy triggers changes in ion channels on dorsal root ganglia and dorsal horn neurons that generate secondary changes resulting in neuropathic pains. Although a number of protective agents have been developed, their effects are not satisfactory. Chemotherapy drugs can cause changes in hippocampal neurogenesis and plasticity. A review reported in the Neural Regeneration Research (Vol. 8, No. 17, 2013) focuses on chemotherapy-induced neurodegeneration and hippocampal dysfunctions and related mechanisms as measured by in vivo and in vitro approaches, which is helpful in determining how best to further explore the causal mechanisms of chemotherapy-induced neurological side effects and in providing direction for the future development of novel optimized chemotherapeutic agents.

Yang MY, Moon CJ. Neurotoxicity of cancer chemotherapy. Neural Regen Res. 2013;8(17):1606-1614

Do Statins Produce Neurological Effects?

Statins can indeed produce neurological effects. These drugs are typically prescribed to lower cholesterol and thereby reduce the risk of heart attack and stroke. Between 2003 and 2012 roughly one in four Americans aged 40 and older were taking a cholesterol-lowering medication, according to the Centers for Disease Control and Prevention. But studies show that statins can influence our sleep and behavior—and perhaps even change the course of neurodegenerative conditions, including dementia.

The most common adverse effects include muscle symptoms, fatigue and cognitive problems. A smaller proportion of patients report peripheral neuropathy—burning, numbness or tingling in their extremities—poor sleep, and greater irritability and aggression

Interestingly, statins can produce very different outcomes in different patients, depending on an individual’s medical history, the statin and the dose.

Gait Abnormalities

Gait abnormality is a deviation from normal walking (gait). Watching a patient walk is the most important part of the neurological examination. Normal gait requires that many systems, including strength, sensation and coordination, function in an integrated fashion. Many common problems in the nervous system and musculoskeletal system will show up in the way a person walks.

Persons suffering from peripheral neuropathy experience numbness and tingling in their hands and feet. This can cause ambulation impairment, such as trouble climbing stairs or maintaining balance. Gait abnormality is also common in persons with nervous system problems such as Multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, Myasthenia gravis, Normal Pressure Hydrocephalus, and Charcot-Marie-Tooth Disease.

Orthopedic corrective treatments may also manifest into gait abnormality, such as lower extremity amputation, post-fracture, and arthroplasty (joint replacement). Difficulty in ambulation that results from chemotherapy is generally temporary in nature, though recovery times of six months to a year are common. Likewise, difficulty in walking due to arthritis or joint pains (antalgic gait) sometimes resolves spontaneously once the pain is gone. Hemiplegic persons have circumduction gait and those with cerebral palsy often have scissoring gait.

#gait #neurology #usmle #doctordconline #neuroscience #diagnosis #usmlestep1 #doctor #neurologist #nhs #hospital #patient #nurse #nursing #mbbs #md #medicine #medstudent @doctordconline

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iamthebestyoullneverhave  asked:

I'm looking for some more spoonies to talk to. I'm going through a rough patch at the moment due to another treatment not working out and just need to talk to some people who understand. Would you be okay posting this to help me find more friends in the community? I have Sjogren's, small fiber neuropathy and fibromyalgia. Thanks so much. I really appreciate it.

Hi friend! I’m going to post this in the hopes that people will pop over to befriend you :D Also go ahead and follow those who like and reblog this post!
We’ve had a lot of people offer to chat with spoonies on here in the past, so hopefully they show up! ^^

If you don’t find many feel free to come back and I can recommend a few people from my personal follows that I know/am friendly with.

-Admin E

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Mustn't grumble

Waiting in emerg while Al has his foot looked at. Is it a broken toe? Is it gout? Should I be taking wagers? In any case he, like my cat, is a little broken. It must really hurt though if he’s complaining because he just doesn’t as a rule.

Gizmo’s happy and engaged in his life. But he is seriously disabled with the neuropathy and plantigrade stance. He still mouses and such, it just takes him longer to get around. We’ve modified the environment with stepstools and I may yet move a litter box upstairs to help a bit. Hopefully it improves. If not, we’ll cope.

All things considered I’m in a really good mood which helps me cope with the above. Maybe it’s the sunshine. Let the happy days outnumber the gloomy ones. Let the energetic days outnumber the void ones. This is my prayer!
Does vitamin D have any role in the improvement of diabetic peripheral neuropathy in type 1 diabetic patients?



The aim of this study was to evaluate the relationship between diabetic peripheral neuropathy (DPN) and vitamin D, nerve growth factor (NGF) and oxidative stress markers in patients with type 1 diabetes.


Ninety-six patients with type 1 diabetes were included in the study. All patients were evaluated for DPN with Michigan Neuropathy Screening Instrument. Fasting blood glucose, HbA1c, lipid parameters, 25 (OH) D3, NGF, total oxidant status, total antioxidant status and oxidative stress index were measured.


Twenty-six patients (27 %) had DPN (group 1) and 70 patients did not have neuropathy (group 2). When the groups were evaluated with respect to general demographic characteristics, no differences were detected. Mean age, duration of diabetes and retinopathy were found significantly higher in patients who had neuropathy. Glomerular filtration rate levels were significantly lower in the neuropathy group. Between the groups, 25 (OH) vitamin D levels were significantly lower in the neuropathy group, while there were no differences in NGF levels or in oxidative stress markers. Michigan neuropathy examination score was positively correlated with age, and diabetes duration was negatively correlated with 25 (OH) vitamin D levels. In addition, 25 (OH) vitamin D was positively correlated with NGF. In the logistic regression analysis to determine the independent variables that will affect the development of neuropathy, duration of diabetes was detected as the only factor (p = 0.039, OR = 1.071).


It seems that the most important risk factor for the development of neuropathy in type 1 diabetic patients is disease duration.

from Endocrinology via xlomafota13 on Inoreader

My mother had diabetic neuropathy in her legs and chest. She told me it felt like her feet were asleep with a burning sensation. There was a whole day she walked around her house and heard a clicking sound following her. She would look behind her all day. It wasn’t until the evening she found a tack imbedded in her heel. She rarely complained about her aches and pains. She nearly ruined her liver from taking aspirin.
I have sciatica, which has left my foot tingling and numb. I can’t stop whining.

This is me, all the live long day.


I fear that I could be turning into her, and it scares me. I just want to be normal again.

timehop reminds that a year ago today, I was inpatient, paralyzed with weakness and neuropathy, every muscle degenerated. I was skin and bones and fat. I was in withdrawal from IV pain meds. I was a terror, a beast hiding inside a paper crane. I remember dreaming of the walk I took this morning after a sleepless night. I was thinking how we all deserve to see beauty. I am thinking: keep going. (at Asbury Park Beach)

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i honestly don’t know any vegans who aren’t ableist as fuck

like, i have severe b-12 deficiency. b-12 is a vitamin you CANNOT get from non animal products.  I have permanent neuropathy in my legs that will never go away because of my lack of b-12

 not to mention vegans going LOL IM POOR AND VEGAN!!!!!!!!!! when you spend 700$ a month and medications to keep you functioning maybe you can afford veganism, but a shit ton of disabled ppl can’t

also shout out to the vegan who told me it would better for me to die from natural selection instead of living on a non-vegan diet!!!