myocyte

Heart muscle cell. Coloured scanning electron micrograph (SEM) of a heart muscle cell (cardiac myocyte). Cardiac muscle is a specialised type of striated muscle found in the heart. It is the constant contraction of cells like this that pump blood around the body with each beat of the heart. This cell has been grown in a cell culture. Magnification: x600 when printed at 10 centimetres wide.

Today huge news, the article I’ve worked a bit for is on the cover of Journal of Cell Biology.

Above, the cover picture : Quick-freeze, deep-etch transmission electron microscopy of myotube plasma membranes shows an abundance of large clathrin lattices (depicted in various pseudocolors) associated with branched actin filaments. Vassilopoulos et al. reveal that these clathrin plaques help to organize skeletal muscle sarcomeres and attach them to the muscle cell membrane.

Vassilopoulos S. et al. (2014) Actin scaffolding by clathrin heavy chain is required for skeletal muscle sarcomere organization. J Cell Biol, 205 (3):377

Muscle-powered bio-bots walk on command

Muscle-powered bio-bots walk on command #biologicalrobots

A new generation of miniature biological robots is flexing its muscle.

Engineers at the University of Illinois at Urbana-Champaigndemonstrated a class of walking “bio-bots” powered by muscle cells and controlled with electrical pulses, giving researchers unprecedented command over their function. The group published its work in the online early edition of Proceedings of the National Academy of…

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Grounded

Well. That’s it. The Neurologist I saw last week has permanently (in my medical record) grounded me from flying. It was explained that with my Myocytic Anemia – little, flat red blood cells that can’t hold oxygen – that the pressurized cabin of an airplane could very likely cause me to pass out. This would lead to the possibility that I simply might not wake up. This also means that the airline does not want to take the risk of transporting me.

Further, it was explained that I could travel via train as long as I had several breaks in which to breathe fresh air. The train (and the plane, too) utilises Recycled Air and the oxygen it contains is not necessarily “optimum” for my needs.

Does it end there? No.

I have also been given medical advice to purchase a Transporting Wheelchair AND a Rollator Walker.

2

Glycogenolysis vs. Glycogenesis Regulation

(Glycogen breakdown vs. Glycogen synthesis)

Key regulating enzyme: Glycogen Phosphorylase (2 forms: a and b)

2 pathways:

  • allosteric pathway: covalent modification
  • hormone pathway: epinephrine on myocyte, glucagon on hepatocyte
Integrative Analysis of Micro#RNA and #mRNA Data Reveals an Orchestrated Function of Micro#RNAs in Skeletal Myocyte Differentiation in Response to TNF... - PubMed - NCBI

@rnomics/RNA ncbi.nlm.nih.gov 200) && (this.width >= this.height) ? 200: true); max-height: 200px; height: expression((this.height > 200) && (this.height >= this.width) ? 200: true); border: none;’/> posted by friends:  (1) @#microRNA_papers: Integrative Analysis of Micro#RNA and #mRNA Data Reveals an Orchestrated Function of Micro#RNAs in Skeletal Myocyte… dlvr.it/BrV0lS 14.08.2015 14.31.16 posted by followers of the list:  (0) http://1.usa.gov/1J4w0WK

2

Non-cardiac Action Potential vs. Cardiac Action Potential

1. Non-cardiac (neurons, skeletal myocytes, endocrine cells)

  • shorter: 1-2 ms, no plateau
  • ions involved: sodium, potassium

2. Cardiac

  • longer: ~300ms, plateau
  • ions involved: sodium, potassium, calcium
  • calcium influx (depolarization for pacemaker cells, no sodium influx)
  • gap junctions allow faster cell-to-cell communication
  • separated into 2 subsets: pacemaker cells, non-pacemaker cells)

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IN CARDIAC CELLS ONLY:

Pacemaker Action Potential vs. Non-pacemaker Action Potential

1. Autorhythmic myocardium/Pacemaker cells

  • location: electrical conduction system: SA node -> AV node -> Bundle of His -> L & R bundle branches -> Purkinje fibers (functions to synchronize contraction of ventricular cardiac muscle, can also initiate heartbeat if no external stimulus exists)
  • speed: “slow response” slower depolarization
  • depolarization via calcium influx, sets heartbeat

2. Contractile myocardium/Non-pacemaker cells

  • location: all other cardiac myocytes
  • speed: “fast response” faster depolarization
  • depolarization via sodium influx
Integrative Analysis of Micro#RNA and #mRNA Data Reveals an Orchestrated Function of Micro#RNAs in Skeletal Myocyte Differentiation in Response to TNF... - PubMed - NCBI

@rnomics/bioinfo ncbi.nlm.nih.gov 200) && (this.width >= this.height) ? 200: true); max-height: 200px; height: expression((this.height > 200) && (this.height >= this.width) ? 200: true); border: none;’/> posted by friends:  (1) @bioinfo_papers: Integrative Analysis of Micro#RNA and #mRNA Data Reveals an Orchestrated Function of Micro#RNAs in Skeletal Myocyte… dlvr.it/BrSRpk 14.08.2015 13.31.03 posted by followers of the list:  (0) http://1.usa.gov/1J4w0WK