Game of Thrones may be set in a magical realm with fictional creatures that have make-beileve powers, but the science behind the stories is sometimes not far from reality. For example, there are species on Earth that share a surprising number of similarities to the crazy critters from Game of Thrones.
Take the hyperthermophilic bacterium Pyrodictium, which grows in deep-sea vents and can withstand temperatures as high as 400 °C. The Targaryens, then, may just be another example of a hyperthermophile.
You guys, my article finally got published! It was supervised by a geneticist/genetics instructor so I promise you the science in it is fairly legitimate :)!