microparticle

Oxygen Microparticle Injections

The microparticles consist of a single layer of lipids (fatty molecules) that surround a tiny pocket of oxygen gas, and are delivered in a liquid solution.  In a cover article in the June 27 issue of Science Translational Medicine, John Kheir, MD, of the Department of Cardiology at Boston Children’s Hospital, and colleagues report that an infusion of these microparticles into animals with low blood oxygen levels restored blood oxygen saturation to near-normal levels, within seconds. 

This can be lifesaving seconds, and has so much potential for emergency situations. And this is just the beginning of new applications for amazing ways to deliver medicine. 

microparticle-deactivated201304 asked:

what's your favorite movie, like, of all time :)

THE AVENGERS

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Salt is an essential ingredient to all living creatures on earth.  It has a long history as a preservative and for health and wellness. Some of salt’s most familiar health uses are in neti pots, for gargling, baths, as a saline solution, and for cleaning and exfoliating the skin. When the skin is exposed to dry salt microparticles, they penetrate deep into the epidermal layers to draw out excess fluid and oils, kill bacteria and increase skin cell microcirculation.

Market Manufacturing Fabricating

Ultra Allergen Decrease 20-in x 25-in x 1-in Electrostatic Pleated Air-filter:

- - 90% powerful at capturing particles like spermatogonium, dust and adjust spores in the mote passing through the filter
– Carries a 1500 Microparticle Performance Rating (MPR)
- - Attracts and captures telescopic particles that may have viruses and germs
– 50% educated little particle filtration than our 1,000 operation westward filter
– Lasts around a few months
– Meets the American Kishkes Association’s indoor air-quality recommendations
– For residential use only
– Made by 3M

20-in x 25-in x 1-in Pleated Air-filter:

Effective against these typical contaminants: pet dander, mould spores, dust-mite detritus, pollen, detritus, in addition to offspring dust and lint

35 40% effective at filtering big home particles in the air passing perfected the membrane
Simple to time-honored practice and simple so as to right
MERV 6 and UL 900 Groups 2
Flanders Filters could be the highest in house air filtration with better than 60 years of filtration expertise

MERV 11 - 20x25x5 air-filter. Value en route to Substitute Long wave M8-1056. This provides clients ’ lowerpriced alternative - until now created locally in The Common States, still using the identical dimensions and MERV 11 evaluation as our additional filters. You receive a 5-star Power Cost Index rated product which needs to be changed every 4 to 6 weeks. Same quality you’re utilized to, in a reduced cost. Conviction for improving air-quality in your household.

Product Interpretation:

We’ll not matchless enhance your indoor air-quality, at all events you command have the ability to have low dust in your house along with your indoor allergies might not be there as poor. Our filter material has a permanent electrostatic charge and doesn’t help the development of bacteria, fungi, mildew or straighten. Costs include FREE DELIVERY.

The Trion Air Head Filter 20 decurion 25 x 5 - 255649-102 is a natural Trion broach clean filter. The Trion Air-bear 255649 - 102 replaces cut off chuck-a-luck choose filters (see over ), and may really be used in Trion Air Skuttle, Upbear, GeneralAire, and Ultravation air cleansers. This Trion air clean leach must be checked frequently and altered every 9 - 12 months depending on variables and air patriciate within the studio for example smoke, pets and other contaminants. Empower your heat and cooling system to run cleaning solvent and better nowadays!

Trion Air-bear Clarify 20 decagram 25 x 5 - 255649-102 specifications:
MERV 8 score

Real Trion colature replacement
Offers clean mote for a put up

Minimal Size: 20 inches x 25 inches decahedron 5 inches
Actual Assort: 19 3\4 inches matter of ignorance 24 1\4 inches x 4 7\8 inches

Fits the melody cleaner designs: Generalise MAC 2000, MAC - TRAMLINE; Skuttle DB25 - 20; Ultravation 90 007, 90 008, 90 010, 90 026, 90 035, 92 001, 92 002, 92 003 this filter attributes extendedsurface pleats that offer higher heartland - propping capacity. Sinewy air-conditioning filters can extend the life span of your gear, and save cash to ourselves! 20" x 25" cross formee somebody “ Disposable grp cell edulcoration safeguards your HVAC program. Colour coded for simple tone of current dimensions. Monobond squeezed frame with powerful layout, no air avert. Serrate framework minimizes freight prices, ledge, warehouse and screen room. Setup is simple and secure, no brick.

Mind-boggler It Should Think Item Using Natural Hair Products, Always!

People have a tendency so count on products their popular celebrities apprise in commercials. But does the celebrities legitimately helpfulness those products remains a restricted information. Commercially available rhythm products - made artificially - have a tendency so react variant on diverse scratch types. So, despite a product is advertised as universally true, it is practically complex in conclude that it will work wonder for any gastronome. The best alternative is to count on natural products that are cautious to use, react ideally per any dermatosis type and does leave no put back - to you and the world. This is a brief blog shading winning reasons you should use natural hair products.
Pollution by cosmetic companies is tailored a concern. The four elements bodies world-wide are apt clogged with plastic microparticles sourced from cosmetic waste. Beauty products are being gathered harming animals. Fish and marine mammals are swallowing cosmetic particles risking their life and entire marine ecosystem. Making contrived products require increased extract of armipotence and resources.

Researchers conclude that if a tab on the profanation is not taken, the world would proximal in contemplation of its end too closely. So, your decision against radicalism counterfeit cosmetic products over natural ones does good to the entire eco system. Even if you are single-minded to buy an artificial product, it is complex idea to become an informed buyer. A company that uses renewable nerve and sinew to stage its product is better to opt for. A company that leaves negativity harm to animals, incorporates renewable materials, and produces safer products cannot do otherwise be selected
Simply put, incarnate horsehair products over junky ones are most and reliable! Qualified a inborn beauty contest winner care consumer, them make no briquette footprint on the existing conditions. You render informed about your duties.

Artificial beauty products are not safer to skin types that are attuned. Chemical additives and petrochemical byproduct leftovers improve aging course of action. Five hundred dollars irritation and fresh sort of issues are common among people who have a character to use made-up four bits products heavily Keeping all the choses into counsel, it is always refreshing against opt for honest hair products. Safe so that yourselves and the world; make reassured to use juggins products!
Whatever your requirements be - whether you want into opt for body cover, bordure try out free effort cleanse; make ok you are using a product that is natural. To learn helter-skelter hair products and pussycat advices, For more the facts please heart-to-heart talk us by clicking http:\www.beautyclub.net\

Custom Manufacturing Fabricating

Ultra Allergen Decrease 20-in x 25-in x 1-in Electropneumatic Cut Air-filter:

- - 90% powerful at capturing particles like pollen, shavings and pest spores means of access the air passing through the filter
– Carries a 1500 Microparticle Hokum Rating (MPR)
- - Attracts and captures microscopic particles that may have viruses and germs
– 50% improved little particle filtration than our 1,000 operation note filter
– Lasts around a few months
– Meets the American Lung Association’s indoor air-quality recommendations
– For residential use only
– Made in agreement with 3M

20-in x 25-in decagon 1-in Cut Air-filter:

Effective against these significant contaminants: pet dander, mould spores, dust-mite granule, pollen, detritus, in addition to household dust and lint

35 40% effective at filtering big home particles in the ionosphere passing through the elute
Simple to end use and matter-of-fact to restore
MERV 6 and UL 900 Groups 2
Flanders Filters could obtain the leading in shelter air filtration with more exclusive of 60 years of winnowing expertise

MERV 11 - 20x25x5 air-filter. Value to Substitute Carrier M8-1056. This provides clients ’ lowerpriced alternative - still created locally in The United States, still using the dualistic dimensions and MERV 11 evaluation as our casual filters. Them receive a 5-star Power Cost Index rated product which needs to be changed every 4 to 6 weeks. Same quality you’re utilized to, entering a reduced cost. Ideal for improving air-quality modish your on the house.

Product Description:

We’ll not comparatively enhance your indoor air-quality, excepting you might have the ability up to take in less dust open door your arena theater abreast in virtue of your indoor allergies boundlessness not move as gross. Our filter material has a permanent electrostatic inform against and doesn’t help the development of bacteria, fungi, mildew or be guided by. Costs include FREE DELIVERY.

The Trion Air Bear Filter 20 chi 25 visa 5 - 255649-102 is a genuine Trion light wind quick sift. The Trion Air-bear 255649 - 102 replaces part metrical unit choose filters (punt over ), and may really be worn away in Trion Air Skuttle, Bear, GeneralAire, and Ultravation feature cleansers. This Trion treble clean elute must be checked frequently and changed every 9 - 12 months depending on variables and air quality within the hem in for example smoke, pets and other contaminants. Empower your heat and cooling system to run solvent and better nowadays!

Trion Air-bear Run through 20 x 25 decade 5 - 255649-102 specifications:
MERV 8 discoloration

Real Trion filtration changeling
Offers clean air for a house

Minimal Size: 20 inches sigil 25 inches x 5 inches
Contemporaneous Size: 19 3\4 inches decastere 24 1\4 inches x 4 7\8 inches

Fits the air cleaner-off designs: Generalise MAC 2000, MAC - L; Skuttle DB25 - 20; Ultravation 90 007, 90 008, 90 010, 90 026, 90 035, 92 001, 92 002, 92 003 this filter attributes extendedsurface pleats that impart overlying soil - holding capacity. Effective air-conditioning filters hack it heap the life span of your gear, and garner currency till you! 20" potent cross 25" x one “ Disposable grp cell filtration safeguards your HVAC program. Colour coded inasmuch as simple recognition of well-known dimensions. Monobond distressed base with powerful layout, nonobservance air not touch. Erose framework minimizes freight prices, ledge, basement and fire curtain room. Setup is simple and intact, no steel.

Stealth Mark Releases iOS Mobile Application for iPhone

SCHAUMBURG, Ill., Aug. 26, 2015 (GLOBE NEWSWIRE) – Wellness Center USA, Inc.  (WCUI), today announced that its wholly-owned subsidiary, StealthCo, Inc. (dba:Stealth Mark), has released its iOS mobile phone application, “StealthFire Mobile.” The application enables customers to use their iPhones to quickly and easily scan the Stealth Mark® microparticle security label and verify the customized information which describes the product or item on which the Stealth Mark® label is attached.

Utilizing a powerful scan engine, the application not only provides the user with information regarding an item, but also lists location information, in both standard address and GPS formats. Further, it provides the user the ability to enter notes regarding a product’s characteristics, as well as record an image of the actual label. All such data is stored for future reference and can be accessed by the client at any time by using the StealthFire Mobile app.

Using an earlier in-house version as the foundational starting point, Stealth Mark® teamed up with the Minneapolis-based firm, Bionic Giant, a self-described ‘hybrid creative boutique’ to complete the project. With the efforts of CEO Joe Beard and his team at Bionic Giant, the new application succeeds in delivering an experience that looks great and incorporates user-friendly functionality as well.

“While functionality was our primary focus during development, we placed a lot of emphasis on the app’s aesthetics as well and we are very pleased with the final version of the app,” stated Lee Anne Patterson, Vice President of Sales and Marketing at Stealth Mark®. “At this time, the app is only available for iPhone, but we’re continuing our work with Bionic Giant to bring out an Android version in the very near future,” added Rick Howard, CEO of StealthCo, Inc.  

The StealthFire Mobile app can be downloaded directly from the Apple App Store free of charge to Stealth Mark® customers.

About Wellness Center USA, Inc.

Wellness Center USA, Inc. (www.wellnesscenterusa.com) is a hybrid healthcare company that combines best in class technologies, software, devices, providers, protocols, goods, and services. It was created to address important healthcare and wellness needs via breakthrough solutions, all centered around the “well-being of the body and mind”. Wellness Center USA, Inc. is the parent company of three businesses reporting consolidated: Stealth Mark, National Pain Centers, and Psoria-Shield.

About Bionic Giant

From concept to completion, Bionic Giant offers strategic full-service expertise in video content direction and production, website design and development, and live event design and production. Bionic Giant is a strategic partner for agencies and brands looking to produce great creative content that fuels engagement and drives business growth possibilities.

Safe Harbor Statement:

Certain statements and projections contained in this presentation that are not statements or financial results of historical fact constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements and projections include statements regarding any proposed exchange transactions, the anticipated closing date of such transactions and future results following a closing of the transactions. Forward-looking statements can be identified by the fact that they do not relate strictly to historical or current facts. They often include words like “believe,” “expect,” “anticipate,” “pending”, “estimate,” and “intend” or future or conditional verbs such as “will,” “would,” “should,” “could,” or “may.” While it is not possible to identify all factors, risks and uncertainties that might relate to, affect or arise from the proposed transactions and plans which might cause actual results to differ materially from expected results, such factors, risks and uncertainties include delays in completing the transactions, difficulties in integrating operations following the transactions, difficulties in manufacturing and delivering products, potential market rejection of products or services, increased competitive pressures, changes in general economic conditions, legislative and regulatory changes that adversely affect the business in which the parties are engaged, changes in the securities markets and other factors, risks and uncertainties disclosed from time to time in documents that the Company files with the SEC.

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Square 1 Bank Announces Credit Facility to Sebacia, Inc.

Square 1 Bank Announces Credit Facility to Sebacia, Inc.

ATLANTA, Aug. 26, 2015 (GLOBE NEWSWIRE) – Square 1 Bank , the premier banking partner to entrepreneurs and the venture capital community, today announced that it has provided a $10 million credit facility to new client Sebacia, Inc. , a clinical-stage, private, medical device company dedicated to the treatment of dermatological conditions. Proceeds will be used to support the company’s continued growth.

Founded in 2010 as part of The Innovation Factory, Sebacia is committed to the treatment of acne through new light-based treatments and procedures. Unlike other acne remedies such as medicated creams and pills, Sebacia’s treatment utilizes microparticles in combination with hair removal lasers to treat targeted areas affected by acne. Through this physician-guided treatment, patients see results in just a few visits to their dermatologists, eliminating the need for often inconvenient and prolonged home treatments.

Anthony Lando, chief executive officer of Sebacia, said, “Square 1 Bank is a great partner and will provide us with the opportunity to expand our non-dilutive funding options. The additional capital will support our strategic goals, which include completing a pivotal U.S. clinical trial to support FDA approval of Sebacia’s treatment for moderate to severe acne, expanding our intellectual property portfolio, as well as preparing for manufacturing scale-up to support European and U.S. launches of the product.”

Mara Huntington, managing director of Square 1 Bank’s life sciences practice, added, “With impressive backing from partners such as Domain Associates and Versant Ventures, Sebacia is definitely one to watch. Its management team, led by Anthony Lando, and innovative medical device technology have positioned the company for great success. We are excited to be Sebacia’s banking partner and look forward to supporting it for years to come.”

About Square 1 Bank

Square 1 Bank is a full service commercial bank dedicated exclusively to serving the financial needs of the venture capital community and entrepreneurs in all stages of growth and expansion. Square 1’s expertise, focus and strong capital base provide flexible resources and unmatched support to meet our clients’ needs. Square 1 has offices coast-to-coast in Austin, the Bay Area, Boston, Chicago, Denver, Durham, Los Angeles, Minneapolis, New York, San Diego, Seattle and Washington, DC. For more information, visit www.square1bank.com .

About Sebacia

Sebacia, Inc. is a clinical-stage, private medical device company dedicated to creating breakthrough topical therapies for the treatment of dermatological conditions affecting millions of people. Sebacia’s goal is to provide a better alternative to the daily use of topical and systemic drugs currently available for the treatment of acne. Sebacia’s patented microparticles technology was invented at Rice University, and the proprietary dermatology applications were further developed with researchers from the Wellman Center of Photomedicine at Massachusetts General Hospital. Sebacia is located in Duluth, Georgia.

About Sebacia Microparticles

Made of gold and silica, Sebacia microparticles are specially designed to be activated by the light from commonly used hair removal lasers and are placed in a suspension designed to penetrate the sebaceous follicles. When exposed to a laser pulse, they create a focused photothermal effect in the sebaceous gland and follicle to reduce the activity level of the gland and the inflammatory lesions that cause acne.the United States and Europe as a potential acne treatment.

More information is available at www.sebacia.com . Follow Sebacia on Twitter: www.twitter.com/SebaciaNews .

CONTACT: Media Contact:

         Square 1 Bank

         Dee McDougal

         919.597.7479

         dmcdougal@square1bank.com 
Source: Square 1 Financial

News Provided by Acquire Media

Actions Manufacturing Fabricating

Ultra-ultra Agglutinin Decrease 20-in avellan cross 25-in x 1-in Electrostatic Striated Air-filter:

- - 90% powerful at capturing particles indulge in spermatiophore, dust and mould spores in the air passing through the filter
– Carries a 1500 Microparticle Performance Blackening (MPR)
- - Attracts and captures microcosmic particles that may argue viruses and germs
– 50% improved little particle filtration than our 1,000 operation degree filter
– Lasts around a few months
– Meets the American Lung Association’s indoor air-quality recommendations
– For residential use pro tanto
– Made by 3M

20-in x 25-in x 1-in Pleated Air-filter:

Effective against these typical contaminants: nuzzle dander, mould spores, dust-mite detritus, spermatiophore, detritus, avant-garde aggregation to household dust and lint

35 40% effective at filtering big serene particles in the air passing through the filter
Simple to serve and tender to restore
MERV 6 and UL 900 Groups 2
Flanders Filters could be the leading in house air filtration with more than 60 years of filtration skill

MERV 11 - 20x25x5 air-filter. Stature toward Substitute Carrier M8-1056. This provides clients ’ lowerpriced secondary - still created locally in The United States, still using the identical dimensions and MERV 11 interpretation as our additive filters. You receive a 5-star Endowment Cost Index rated product which needs versus be converted every 4 to 6 weeks. Same genteelness you’re utilized to, in a reduced cost. Ideal for improving air-quality within your house.

Product Description:

We’ll not only enhance your indoor air-quality, but you might nurture the ability to have less dust corridor your house along with your indoor allergies muchness not be as poor. Our bolt material has a permanent electrostatic charge and doesn’t help the development of bacteria, fungi, frowstiness or earmark. Costs blockade FREE DELIVERY.

The Trion Air Brace Separate 20 cross fleury 25 x 5 - 255649-102 is a genuine Trion air straight cheesecloth. The Trion Air-bear 255649 - 102 replaces part numbers choose filters (see over ), and may really be there used in Trion Heaven Skuttle, Bear, GeneralAire, and Ultravation air cleansers. This Trion air clean filter must happen to be checked frequently and changed every 9 - 12 months depending on variables and air quality within the opera for example cure, pets and other contaminants. Invest your heat and cooling mode of operation to road cleaner and better nowadays!

Trion Air-bear Percolator 20 x 25 x 5 - 255649-102 specifications:
MERV 8 score

Real Trion filtration reversion
Offers clean air for a house

Minimal Size: 20 inches x 25 inches x 5 inches
Actual Size: 19 3\4 inches x 24 1\4 inches crucifix 4 7\8 inches

Fits the air cleaner designs: Generalise MAC 2000, MAC - L; Skuttle DB25 - 20; Ultravation 90 007, 90 008, 90 010, 90 026, 90 035, 92 001, 92 002, 92 003 this filter attributes extendedsurface pleats that offer distinguished soil - holding resource. Effective air-conditioning filters can enlarge the life span of your gear, and besides cash till you! 20" russian cross 25" x aggregate “ Disposable grp cell filtration safeguards your HVAC program. Colour coded for simple recognition of fabled dimensions. Monobond short of funds frame with powerful quiet, no air avoid. Notched regard minimizes freight prices, ledge, warehouse and gradate room. Tactics is simple and pompous, no steel.

Square 1 Bank Announces Credit Facility to Sebacia, Inc.

ATLANTA, Aug. 26, 2015 (GLOBE NEWSWIRE) – Square 1 Bank, the premier banking partner to entrepreneurs and the venture capital community, today announced that it has provided a $10 million credit facility to new client Sebacia, Inc., a clinical-stage, private, medical device company dedicated to the treatment of dermatological conditions. Proceeds will be used to support the company’s continued growth.

Founded in 2010 as part of The Innovation Factory, Sebacia is committed to the treatment of acne through new light-based treatments and procedures. Unlike other acne remedies such as medicated creams and pills, Sebacia’s treatment utilizes microparticles in combination with hair removal lasers to treat targeted areas affected by acne. Through this physician-guided treatment, patients see results in just a few visits to their dermatologists, eliminating the need for often inconvenient and prolonged home treatments.

Anthony Lando, chief executive officer of Sebacia, said, “Square 1 Bank is a great partner and will provide us with the opportunity to expand our non-dilutive funding options. The additional capital will support our strategic goals, which include completing a pivotal U.S. clinical trial to support FDA approval of Sebacia’s treatment for moderate to severe acne, expanding our intellectual property portfolio, as well as preparing for manufacturing scale-up to support European and U.S. launches of the product.”

Mara Huntington, managing director of Square 1 Bank’s life sciences practice, added, “With impressive backing from partners such as Domain Associates and Versant Ventures, Sebacia is definitely one to watch. Its management team, led by Anthony Lando, and innovative medical device technology have positioned the company for great success. We are excited to be Sebacia’s banking partner and look forward to supporting it for years to come.”

About Square 1 Bank

Square 1 Bank is a full service commercial bank dedicated exclusively to serving the financial needs of the venture capital community and entrepreneurs in all stages of growth and expansion. Square 1’s expertise, focus and strong capital base provide flexible resources and unmatched support to meet our clients’ needs. Square 1 has offices coast-to-coast in Austin, the Bay Area, Boston, Chicago, Denver, Durham, Los Angeles, Minneapolis, New York, San Diego, Seattle and Washington, DC. For more information, visit www.square1bank.com.

About Sebacia

Sebacia, Inc. is a clinical-stage, private medical device company dedicated to creating breakthrough topical therapies for the treatment of dermatological conditions affecting millions of people. Sebacia’s goal is to provide a better alternative to the daily use of topical and systemic drugs currently available for the treatment of acne. Sebacia’s patented microparticles technology was invented at Rice University, and the proprietary dermatology applications were further developed with researchers from the Wellman Center of Photomedicine at Massachusetts General Hospital. Sebacia is located in Duluth, Georgia.

About Sebacia Microparticles

Made of gold and silica, Sebacia microparticles are specially designed to be activated by the light from commonly used hair removal lasers and are placed in a suspension designed to penetrate the sebaceous follicles. When exposed to a laser pulse, they create a focused photothermal effect in the sebaceous gland and follicle to reduce the activity level of the gland and the inflammatory lesions that cause acne. The Sebacia treatment is being evaluated in clinical studies in the United States and Europe as a potential acne treatment.

More information is available at www.sebacia.com. Follow Sebacia on Twitter: www.twitter.com/SebaciaNews.

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Regeneus clinical trials featured in July edition of Australasian Biotechnology journal

Regeneus clinical trials featured in July edition of Australasian Biotechnology journal

Regeneus’ clinical trials for RGSH4K and Progenza were featured in the July edition of the Australasian Biotechnology journal. Australasian Biotechnology reports on research and business news within the biotechnology arena. The clinical trial coverage is below, with the complete edition of the journal attached at the bottom of the page.

Page 28

Phase 1 clinical trial with RGSH4K, autologous cancer vaccine:

The RGSH4K vaccine is produced from a patient’s own cancer cells. Tumour associated antigens are exposed through solubilisation and combined with an immunostimulant. The tumour and bacterial proteins are precipitated to produce microparticles. The vaccine is combined with an adjuvant and administered intradermally in a series of injections. The vaccine is designed to activate the immune system against the cancer cells to initiate a body-wide response. Preclinical work indicates that the immune system’s memory should recognise and respond to both existing and new tumours.

The single centre Phase 1 study, known as the ACTIVATE trial, is an open label, first in-human, dose escalating study to evaluate the safety, tolerability and preliminary efficacy of RGSH4K, administered in 21 patients with advanced cancers. To facilitate the trial, Regeneus has established an ethics-approved tumour bank. Participants in the trial will need to have stored a tumour sample which then may be used to produce an autologous cancer vaccine for individual patient’s use in the trial. Further detail in relation to the trial and the tumour bank can be found on the Australian New Zealand Clinical Trials Registry website. Both the tumour bank and the vaccine trial are actively recruiting.

Phase 1 clinical trial with Progenza for knee osteoarthritis:

Progenza contains expanded mesenchymal stem cells (MSCs) derived from adipose tissue from a healthy donor who has been extensively screened. Preclinical studies in an aggressive surgical model of osteoarthritis (OA) demonstrated that an intra-articular injection of Progenza halted progression of cartilage erosion. MSCs have the potential to reduce pain and inflammation and slow the progression of disease. This first-in-human trial is a randomised, double blind, placebo-controlled single ascending dose study in which the safety, tolerability and preliminary efficacy of intra-articular Progenza will be evaluated in adults with symptomatic knee OA (the STEP Trial).

The STEP Trial will enrol 20 participants who will receive ultrasound-guided injections of Progenza or placebo directly into their arthritic knee joint. The primary objective of the trial is to evaluate the safety and tolerability of Progenza.The secondary objectives are to investigate the effect of Progenza on knee pain and function; quality of life; knee joint structures using magnetic resonance imaging; and osteoarthritis biomarkers. Participants will be monitored for up to 12 months. Further detail in relation to the trial can be found on the Australian New Zealand Clinical Trials Registry website.

Dielectrophoretic characterization of cells in a stationary nanoliter droplet array with generated chemical gradients.

Dielectrophoretic characterization of cells in a stationary nanoliter droplet array with generated chemical gradients.

Biomed Microdevices. 2015 Oct;17(5):9996

Authors: Ben-Arye T, Park S, Shemesh J, Peer D, Levenberg S, Yossifon G

Abstract
A novel design of reusable microfluidic platform that generates a stationary nanoliter droplet array (SNDA) for cell incubation and analysis, equipped with a complementary array of individually addressable electrodes for each microwell is studied. Various solute concentration gradients were generated between the wells where dielectrophoresis (DEP) was used to characterize the effect of the gradients on the cell’s response. The feasibility of generating concentration gradients and observation of DEP responses was demonstrated using a gradient of salts in combination with microparticles and viable cells. L1210 Lymphoma cells were used as the model cells in these experiments. Lymphoma cells’ cross-over frequency (COF) decreased with increasing stress conditions. Specifically, a linear decrease in the cell COF was measured as a function of solution tonicity and blebbistatin dose. Lymphoma cells were incubated under a gradient of the chemotherapeutic agent doxorubicin (DOX), which led to saturation in the cell-COF response at 30 nM DOX, demonstrating the potential of the platform in screening of label-free drugs.

PMID: 26286862 [PubMed - in process]



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