Bacteria produce the chemical
N-formyl-methionine serving as a powerful attractant to neutrophils and
macrophages within the body. Through chemotaxis, neutrophils will enter through
the blood vessels via diapedesis, going across the intact vascular wall by
squeezing themselves and elongation to go at the site of inflammation. Once the
neutrophils recognized the receptor in the bacteria, attachment will proceed.
Ingested bacteria will be enclosed in a phagosome via phagosome formation then
phagolysosome will ensue. This will activate the respiratory burst necessary
for microbicidal activities within the cell. Two modes of intracellular killing
occurs: oxygen-independent killing without the requirement of respiratory burst
and oxygen-dependent killing catalyzed by myeloperoxidase. Once the cell has
finished digestion, excretion of residual bodies and waste materials will
proceed via exocytosis.