mesenchymal

Fungus Toxin Triggers Stem Cells to Become Bone

Imagine you’re riding your bike and an unseen tree root sends you flying over the handlebars. You stick an arm out to break your fall, except the force is too much. The bones in your forearm snap like a twig.

A trip to the hospital means you’ll either get a cast or surgery to realign the broken bones so that they can heal properly. Afterwards, it can take up to six months before the bones fully recover. Now, though, University of North Carolina School of Medicine doctors say there might be something on the horizon to significantly decrease the time it takes for bones to reform after injury. 

In an unexpected find, they watched a toxin called cytochalasin D (CytoD), which is produced by certain molds, cause stem cells to transform into new bone cells. The process can be seen in the gif above, with a stem cell exposed to CytoD beginning the process of turning into a bone cell. After seeing this change occur in cultured cells, Dr. Janet Rubin and colleagues injected it into mouse shinbones, where they witnessed “abundant bone formation” after just one week.

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Please consider donating. She's fighting to live. She has 4 kids

Amanda vs Bone Cancer

$2,295 of $5,000 goal

My name is Amy Culver and I am raising money for my dear friend and fellow Mama bear Amanda Siegel.

Amanda is a 40 year old wife and Mom of 4 kids, Molly is 19, Jackson is 15, Spencer is 11 and Marin is 7 months. 

She was diagnosed with Mesenchymal Chondrosarcoma in 2009 after a lesion was accidentally discovered on her rib. After surgery to remove the lesion, Drs advised her to do a course of chemotherapy and so her long and grueling story begins. 


Amanda has had nearly 20 rounds of chemotherapy, surgery as well as radiation over the course of her 8 year (and counting) battle. Bone cancer is very painful so this has been a tough road for her. She has lost her hair so many times she jokes she doesn’t even know what her natural hair looks like anymore. She has been in remission several times most recently 2 years ago. 

Amanda was scheduled for a hysterectomy in Philadelphia and had scans days before her scheduled surgery to make sure she was still cancer free and it was discovered she was pregnant. After so many years of treatments this should never have even been remotely possible. Because of this, she was advised to terminate due to the concerns with her health and whether her body could handle this after having gone thru so much. She knew in her heart God wouldn’t have given her this gift after everything she had been thru unless it was meant to be. By the grace of God her beautiful miracle daughter Marin was born last September healthy and whole despite the odds being against her. 

A few weeks after Marin was born, Amanda had a PET scan and it was discovered her cancer had returned and this time with a vengeance and worse than they had feared. Her doctors believe that the hormones that helped bring Marin into the world healthy fueled Amanda’s cancer to grow again and this time faster. Amanda began treatments a few months ago and even battled Pneumonia last month during treatments. 
This past week, after some new symptoms, it was discovered the cancer is now in her bladder. She is scheduled for a biopsy next week so they can figure out what to do next to help her keep fighting this. 


She has always been a source of strength for others and has stayed positive throughout her ordeal but now she is fearing the worst after all these recent set backs and is finding it harder to stay positive like she has been in the past. To say my heart breaks for her is an understatement. I feel helpless and don’t know what to do to help. I know I have asked her “what can I do” over and over and in true Amanda fashion she says “I’m good just take care of you”, Knowing full well she isn’t good. 


So now you know the “health” story, let me tell you about my friend, she is hands down the strongest most selfless woman I know. She drives herself to treatments, sometimes even taking her baby with her, comes home and takes care of her family even an up at night newborn while the chemo side effects made her sick. She does all of her appointments and scans on her own so her husband can focus on his job and not stress over her. She shuttles kids to activities and attends their school events even during her worst days hiding it with a smile and “lots of cover up” she would say. She always strives to keep her families life as normal as possible despite everything she is going thru. She has helped organize cancer fundraisers thru her children’s sports and has a Relay for Life team every year and every year tries to beat a new goal she sets to raise more money to help others. She even ran her first marathon during treatments 3 years ago AND tried out for “The Voice” because my girl can SING!

Despite her enormous pain and stress, she ALWAYS knows how to make you full on belly laugh. She is hilarious and has a very quick whit. She is fun, easy going and always up for anything. She has a way about her that makes you feel comfortable, at ease, never judged and like your her best friend in the world even if she just met you. She would give you the shirt off her back or her last dollar if you needed it more than her.

Throughout the course of these 8 years battling cancer, Amanda and her family have quietly been thru more trials than any family should ever have to go thru. Astronomical medical bills and expenses which have affected every aspect of their life. Their whole family has given up vacations and simple luxuries afforded to most of us just to keep her going to treatments and keep the Mom and wife they love here with them.

Her most recent treatments are costing them over $1200 per week out of their own pockets despite the majority of it being covered by insurance and that is just the treatment, not to mention the tests, medicine and unforeseen expenses with this latest discovery possibly sending her to Philadelphia for more treatments with different doctors.

I know all of this has taken its toll on them mentally and financially and adds so much extra stress to her life. I desperately want to help take even a little stress off of her in any way I can which is why I created this page.
My hope is to give others the chance to help Amanda and her beautiful family, where I know she could use it the most. My warrior friend will never admit she needs help and has never asked for anything so that’s where we can step in and do it for her. 

I would love for this to be successful and for her to have enough to help pay for even just a few weeks of treatments to give them some relief from this non stop financial burden. Maybe even have enough left over for her family to do something fun together and help take their minds off of all of this for a minute.

Please consider helping out my friend in any amount you can because I know it will be truly appreciated. She is someone who genuinely does deserve for life to just cut her a break. 

In the meantime, please do me a favor and keep her and her beautiful family on your heart and in your prayers. 

Thank you and bless you!
Amy

[TRANSLATION] PSYCHO-PASS OFFICIAL PROFILING 2: Tougane Sakuya

Profile: Tougane Sakuya ・東金 朔夜 Codename Hound 3 + Tougane Misako + Additional Pages

 

Here you go, Tougane Sakuya’s profile with What’s Sakuya? section and some data on Misako.

Finally it has been made clear about Misako’s death. And some more trivia on Tougane’s blissful past for you guys to try to say NO to character hate… or to be a little bit more sympathetic …maybe. <3 There’s also some info you already know from the anime that I included anyway since it was originally there.

Contents:

  • Profile: Tougane Sakuya
  • Profile: Tougane Misako

What’s Sakuya?

  • The Jet-black Enforcer. The Secret of his Birth.
  • Tougane Sakuya’s personnel file as of August 1, 2099
  • Tougane Foundation and Tougane Misako
  • List of patents owned by Tougane Foundation (as of 2075)
  • An Artificial Criminally Asymptomatic Being
  • Test Subject Sakuya in Early Childhood
  • Blind Love for his Mother
  • Investigation data on Akane by Sakuya 

「全ては、あなたへの愛ゆえ。・・・母さん」

“I do everything because of my love for you.”

ID: 00475-AECE-45024-2

Kanji name: 東金 朔夜

Romaji name: Tougane Sakuya

Affiliation: Ministry of Health and Welfare, Public Safety Bureau, Criminal Investigation Department, Division 1

Occupation: Enforcer

Date of Birth: June 6, 2073

Age: 41

Blood Type: AB

Address: Tokyo-to, Shin-Chiyoda-ku, Kasumigaseki, 2-1-B, MWPSB

Emergency contact’s address: Tokyo-to, Minato-ku, Akasaka 10-5-12

Azuma Hisako (relation: aunt)

Physical Examination:  N/A

[Education and Career]

April 2080・Entered Private Sakakibara Academy, Elementary School (home schooling system)

June 2083・Hospitalized at Tougane Juridical Foundation Hospital

October 2088・Passed Scholarly Ability Certification Exam on secondary school basis

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World’s first pelvis transplant carried out in Italy.

The Centre for Orthopaedic Trauma (CTO) in Turin, Italy, has performed the world’s first pelvis transplant, an operation that saved the life of an 18-year-old suffering from osteosarcoma. The condition was considered inoperable and the boy responded quite well to 16 cycles of chemotherapy, but the doctors didn’t stop at the traditional treatment, racking their brains to find a definitive solution.

Osteosarcoma is a cancerous tumor in a bone. Specifically, it is an aggressive malignant neoplasm that arises from primitive transformed cells of mesenchymal origin (and thus a sarcoma) and that exhibits osteoblastic differentiation and produces malignantosteoid. Osteosarcoma is the most common histological form of primary bone cancer and it is most prevalent in children and young adults. It tend to occur at the sites of bone growth, presumably because proliferation makes osteoblastic cells in this region prone to acquire mutations that could lead to transformation of cells (RB gene and p53 gene are commonly involved).

In an 11.5-hour operation, surgeons removed half the patient’s pelvis along with part of his hip affected by the cancer, replacing them with a prosthetic made in the United States from titanium covered in tantalum, a non-corrosive metal mainly used in electronics components.

The operation had “an excellent outcome” and the patient is now undergoing intensive therapy to help him adapt to his new pelvis, the hospital said in a statement.

(Picture by Alexey Kashpersky).