Together, they sing this
sermon of endings, at the DMV
on Charleston Street, under a sky
pale as sickness.
“Maybe this is best,” he rinses.
“This was good while it lasted,” she dries.
His breath gathers like silk in the air
and his knuckles are pink from the wind’s bite and
she is leaving, with her suitcase
and her pillow and the canned pineapple
only she buys.
At night, he eats spoonfuls of
honey in the dark. He can feel the bees
swarm in his stomach.
Carving an open wound of him.
Kissing his insides raw.
Some days, he calls, with a mouth
sticky with sweet,
and leaves only the sound of his breathing
in her voicemail, hoping she remembers them
arms touching legs,
pink against pink,
entire worlds curled in their lungs.
Somewhere, men with grey hairs
exchange looks with women in grocery stores,
between the yogurt and the brie.
Pencil sketches of someone else’s
love. Somewhere, mothers with tired hands Google
their way into full, swollen pleasure
and in the morning, cry from
full, swollen guilt.
Somewhere, he sleeps or,
and calls a different girl,
with a different back
and a different voice
by the old girl’s name and knows
that the old girl will
Praiseworthy sternness of this kind has reached a high point among them and bears plenty of fruit. Many of these holy fathers became experts in active life and in spirituality, in discernment and humility. Among them was the awful and yet angelic sight of men grey-haired, venerable, preeminent in holiness, still going about like obedient children and taking the greatest delight in their lowliness. I have seen men there who lived in total obedience for all of fifty years, and when I begged them to tell me what consolation they had won from so great a labor, some answered that having arrived thereby at the lowest depth of abasement they could repel every onslaught, while others declared that they had attained complete freedom from the senses and had obtained serenity amid every calumny and insult.
I saw others among these wonderful fathers who had the white hair of angels, the deepest innocence, and a wise simplicity that was spontaneous and yet directed by God Himself. The fact is that just as an evil person is two-faced, one thing in public and another in private, so a simple person is not twofold, but something whole. There is no one among them who is silly and foolish in the way that some old men in the world are, as they say, senile. No indeed. They are openly gentle, kindly, radiant, genuine, without hypocrisy, affectation, or falsity of either speech or disposition - something not found in many. Spiritually, they are like children, with God and the superior as their very breath, and with the mind’s eye on strict lookout for demons and the passions.
men with grey hair. men with those little smile wrinkles in the corners of their eyes. men with receding hairlines. men with chest hair. men with GREY chest hair. men with smug smiles on thier lips. men with bedroom eyes. men who smell of nice cologne. men with strong veiny hands. men with stubble. men with cuddle bellies. men in tweed suits. men with curls. men with dimples. men with chocolatey deep voices. men who can pick me up on the spot and carry me to bed. men who are shy kissers at first but then pin me against a wall. funny men. older men. chubby men. smol men. soft men. gentle men. passionate men. quiet men. men. I love men. okay. that’s all.
It was found that these drugs had minimal side effects on mice and one of them is already licensed for use in humans and ready for clinical trials, researchers at Medical Research Council’s (MRC) Toxicology Unit in Leicester, UK revealed.
Building up of misfolded proteins takes place in the brain in case of numerous neurodegenerative diseases and it also is one of the main causes of dementias like Prion, Parkinson’s and Alzheimer’s diseases.
Prion diseases refer to a group of progressive neurodegenerative conditions, which can affect both animals as well as humans.
The researchers had previously found that misfolded proteins accumulating in mice having Prion diseases over-activates which halts secretion of new proteins in brain cells. The researchers then used an experimental drug which stopped the neurodegeneration. The major drawback was that the drug used in this experiment turned out to be poisonous to pancreas, hence couldn’t be used for testing on humans.
In the latest research, the scientists tested 1,040 compounds in worms (C elegans), which are considered to be good experimental model for examining medicines that need to be used on the nervous system. The researchers then used mammalian cells to carry out the test on these compounds.
It was found that protein production rates were reinstated in mice by two drugs named trazodone hydrochloride — a licensed antidepressant and dibenzoylmethane — a compound which is being trialled as an anti-cancer medicine.
The emergence of signs of brain cell damage in mice diagnosed with Prion diseases was prevented by both these drugs. Brain shrinkage, which is a characteristic of neurodegenerative disease, was found to be decreased by the drugs in both the mouse models.
“We know that trazodone is safe to use in humans, so a clinical trial is now possible to test whether the protective effects of the drug we see on brain cells in mice with neurodegeneration also applies to people in the early stages of Alzheimer’s disease and other dementias,” said Professor Giovanna Mallucci, who led the team from the MRC.
“We could know in 2-3 years whether this approach can slow down disease progression, which would be a very exciting first step in treating these disorders.”
“Interestingly, Trazodone has been used to treat the symptoms of patients in later stages of dementia, so we know it is safe for this group. We now need to find out whether giving the drug to patients at an early stage could help arrest or slow down the disease through its effects on this pathway,” Mallucci concluded.