No drug makes a person high automatically. One must learn to interpret the physical effects of drugs as the occasions for highs.
It is expectations of individuals and society (set and setting) that encourage people to associate inner experiences with the physical feelings drugs produce. If this association fails to develop or breaks down, people can take the largest imaginable doses of drugs and not get high; just feel drugged. This is precisely the problem of those who get into abusive relationships with drugs by taking them too frequently: as the novelty of the drug’s effect diminishes with repetition, it no longer produces the needed signal.
First experiences are so powerful because the novelty of the change is greatest. It is very easy to confuse the signal with the desired experience, the drug with the high. Many drug users are convinced that the experiences they need come from outside themselves in the form of drinks, joints, pills, and powders. It is this confusion that leads people to abuse drugs, they take more drugs more frequently in pursuit of ever-vanishing highs, when it is rarely known that the set and setting play the major role.
Of course, non-drug highs can present the same problems. People who are dependent on falling in love are equally at the mercy of outside forces. Many individuals get a rush from making money and their lives are consumed in its pursuit. One variation on this theme is addiction to gambling.