lytic cycle

In the lytic cycle, which is considered the main cycle in viral replication, once the viral DNA enters the cell it transcribes itself into the host cell’s messenger RNAs and uses them to direct the ribosomes.

The host cell’s DNA is destroyed and the virus takes over the cell’s metabolic activities.

The virus begins using the cell energy for its own propagation. The virus produces progeny phages. These replicate fast, and soon the cell is filled with 100-200 new viruses and liquid. As the cell starts getting overcrowded, the original virus releases enzymes to break the cell wall. The cell wall bursts – this process is called lysing - and the new viruses are released.

So, in short, in the lytic cycle, the virus hijacks the infected cell and then destroys it. The lytic cycle occurs in virulent viruses. The symptoms from a viral infection occur when the virus is in a lytic state.

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You have a better chance of running into a shiny than running into a wild pokémon with pokérus. Still, this pokémon virus has huge benefits and is sought after in the competitive and casual communities alike. In the game, an infected pokémon will gain double the stats every time it levels up. But what does this mean in a more physical sense?

To start, let’s talk about viruses. We know Pokérus is a virus, which to be honest doesn’t tell us a whole lot. Viruses are as diverse and as crazy as anything, infecting you with everything from colds and flus to rabies and ebola. Their appearances vary as much as their symptoms, and many of them look very alien.

So what exactly is a virus? Cells in your body, along with bacteria, are stand-alone living entities able to eat, grow, and reproduce. Viruses are something different altogether. Viruses are little envelopes full of genetics: a protective protein coating surrounding single or double strands of DNA or RNA.  By themselves, viruses are not able to function. This is why they need to infect a host cell: to live and reproduce.

They do this through the lytic cycle. Basically, a virus will invade a host cell, and take over the cell’s machinery. The virus will trick the cell into working for them: they turn the host cell into little virus-factories, building more and more viruses with the cell’s machinery which then can go and infect new cells.

This is why viruses are contagious. If someone sneezes on you, or you breathe in a virus, it can start entering your cells and start reproducing right away. This is how pokérus is spread. However, it should be noted that a lot of viruses are species-specific; humans cannot be infected with pokérus.

However, pokérus is unique due to its positive effects. Viruses are generally not something you want. For example, a runny nose: cold viruses will infect and kill cells in your nose, and with less cells lining your sinuses, fluid flows freely. Fevers are your bodies response, trying to kill the virus by literally turning up the heat.

So somehow, instead of destroying and taking over host cells, Pokérus viruses benefit them. Pokérus doesn’t infect and kill a pokémon’s cells; it strengthens them. Exactly how is widely up to interpretation. What does a stat boost in-game equate to in real life? 

Maybe the pokémon is buffed up as if on steroids. This would mean that pokérus increases protein production and ATP levels. Or maybe, Pokérus just helps a pokémon grow strong, by enabling them to more easily break down and use vitamins like calicium. It all has to do with whatever the virus’ DNA/RNA strand tells the cell to do. Most viruses just tell the cell to build more viruses, but the pokérus DNA must be like a motivational speech for a cell. And then it replicates and spreads, of course.

Pokérus is a virus, which will take over a pokémon’s cell and cause beneficial side affects, as it reproduces and spreads through a pokémon’s body and eventually into other pokémon.

We all know a virus cannot complete replicative functions without a host cell. It uses the host’s machinery to replicate its DNA or RNA and proteins. Some burst free from the host cells, other’s bud off ( still lytic cycle, just doesn’t lyse the host cell) and yet some just chillax in the host cell as it replicates over and over again. 

When a lambda phage infects a bacteria, it can either enter into the lytic cycle or the lysogenic cycle. In the lytic cycle, the host cell’s machinery is hijacked to only reproduce the phage DNA until enough baby phages can assemble and burst out of the cell to wreak havoc on nearby cells. In the lysogenic cycle, the phage DNA is incorporated into the host cell DNA and is copied quietly alongside it as the cell reproduces. Eventually, through some environmental trigger, this dormant phage DNA in the lysogenic cycle enters the lytic cycle and proceeds as described above.