honestly the zoldyck naming pattern is so lazy lmao

illumi starts off of course with no pattern bc you can’t have a pattern with one name, but every kid after him gets “last syllable of previous sibling’s name + “llu” + another syllable”



Llus Lamp by Vij5

This copper lamp by Dutch designlabel Vij5 does not only show an astonishing material and colour choice, but has a great way of adjusting the height of the lamp. By pulling the loop of the cord, the lamp can easily be adjusted to preferred height. And the loop even gives a great design aspect to the lamp!

Mechanism behind the lack of effectiveness of certain antagonist drugs discovered

Members of the Consolidated Research Group of Molecular Neurobiology of the Department of Biochemistry and Molecular Biology of the University of Barcelona (UB), affiliated with the Centre for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), have published a study in the journal Proceedings of the National Academy of Sciences (PNAS) about the formation of G protein-coupled receptors (GPCRs) which allows understanding the unexpected behaviour of some antagonists that block physiological responses.

The study, carried out with mice and human cell lines, has been led by Vicent Casadó and Enric I. Canela, experts in the Department of Biochemistry and Molecular Biology and members of the Research Group of Molecular Neurobiology of the UB. UB experts Jordi Bonaventura, Verònica Casadó, Gemma Navarro, Estefania Moreno, Marc Brugarolas, Carme Lluís, Josefa Mallol and Antoni Cortés also collaborate in the study, together with the research teams led by Sergi Ferré (National Institute on Drug Abuse, United States), and Serge Schiffmann (Free University of Brussels, Belgium).

Potential drugs to fight against Parkinson’s disease

To be exact, the team has determined that adenosine A2A receptors bind dopamine B2 receptors and form a tetrameric structure (a homodimer of A2A together with a homodimer of D2). The former binding, produced at brain’s basal ganglia, was known but its structure remained unknown. It is one of the mechanisms involved in the control of movement. If it does not work in a correct way, it produces severe movement disorders leading to hypokinesia and hyperkinesia, movement alterations that characterise disorders like Parkinson’s disease, schizophrenia or Huntington’s disease. Considering the interaction between these receptors, it has been suggested that antagonists of receptors A2A are potential drugs to fight against Parkinson’s disease.

The article published in PNAS describes another significant discovery. It describes that the tetrameric structure formed by these receptors explains the discrepancies observed when administering these antagonist drugs because they sometimes produce motor activation but, other times, they worsen motor inhibition.

Beyond the traditional agonist-antagonist model

The tetrameric model discovered by authors explains that a certain concentration of an antagonist drug of adenosine receptors A2A —for instance, caffeine, consumed by a large part of population— blocks movement inhibition caused by adenosine which is produced in an endogenous way by the human body. In higher doses, the antagonist may no longer block the effect of endogenous adenosine and imitate the role played by adenosine, thus limiting the function of dopamine D2 receptors. Therefore, it will not be an effective drug but a drug that damages movement control. The discovery contradicts the traditional point of view that describes antagonists as inactive ligands that only compete with endogenous agonists to bind receptors and block their intracellular activity.

The study of the physiological basis of addiction

Results can be extrapolated to the effect that antagonist drugs have on other receptors which also bind to form heteromers, like the ones that produce addiction to drugs, food and other substances. In fact, the study has proved that the association of many GPCRs receptors forms heteromers with new pharmacological and functional properties, different from individual receptors.

The UB research group, pioneer in the study of these interactions, affirms that “the binding of receptors of hormones, neurotransmitters and neuromodulators forming tetrameters may explain the contradictory results obtained in therapies based on the use of an antagonist drug of a receptor to alter the action of the other receptor and underlines that the success of this type of treatments relies on administering an appropriate dose of the drug”.

CD 34- 3DPO

Omg my husband is worse at symptom spotting than I am. Today he came home for a couple of hours so we could drive to LLU to get the sperm analysis report we had done back in 2013 (I know they might need another but I would like to have this one to show the doctor tomorrow). We went and grabbed some lunch (sad story: we went to a burrito restaurant that we both love and I could only eat half of my burrito, so I took the rest with me and I left it in the car 😞) After we got home I felt so laid down and took and nap. I rarely ever nap, so of course Bill was like “Maybe you’re pregnant?”

Bro I have enough of that going on in my head I don’t need it from you, slow your roll.

midnightswans asked:

jajaja ya te estaba ectrañando! ai mis llu

sho tanviem teh estraneava ak em tanmbler.. i mised iu chu. Hashtag analfabetas (cualquiera que no entienda español, va a pensar que esto es ruso, boe) -hablaban de no publicar los mensajes- -lo publica-

kaimalak asked:

Why Lluthren called his dog "Vehk"?

[[ Because of his heterochromia. 

One of Vehk’s eyes is golden brown(the right) and the other a blue/grey(the left). 

Vivec was gold on one side and a bluish grey on the other, thus Lluthren just thought of Vivec. I’m not sure Vivec would appreciate it, but what they don’t know won’t hurt their pride. 

Also, Vehk just sounds nice. ]]

withtaintedblood asked:

"Sir... Nelos... I got something for you. It's not much, but..." Lluthren stuck out his hand which had a small daisy plant with three flowers on it. "I know it's common, but I thought it was pretty, so..." He started to rub the side of his neck a bit with his free hand, not quite sure where he was headed with his sentence. "I just wanted to give it to you."

Nelos blinked looking at the flowers, he looked confused for a moment then smiled. He reached out, taking the plant, a light blush on his cheeks. He felt giddy, because Lluthren got him something- and it wasn’t any sort of special occasion. 

“It’s lovely!” he said, wrapping his arms around Lluthren to give him a thank you hug for the gift. Being extra careful not accidentally crush the flower.