lipoproteins

Fixing spinal cord injuries

Spinal cord injuries are emblematic of the sort of medical challenge that defies easy or imminent solution. Paralysis is so, well, permanent. But researchers are chipping away at the problem and they are finding glimmers of an answer in surprising places.

In a paper published in The Journal of Biological Chemistry, principal investigator Wendy M. Campana, PhD, professor in the Department of Anesthesiology at UC San Diego School of Medicine and colleagues say a protein known for its role in maintaining cholesterol homeostasis appears to promote axon growth and regeneration after spinal cord injury.

The low-density lipoprotein receptor-related protein 1 (LRP1) is involved in endocytosis, a process used by cells to absorb molecules too large to pass through their membranes. Specifically, it regulates chylomicrons, one of five major groups of lipoproteins that enable cholesterol to move within the water-based solution of the bloodstream.

But it also acts as a signaling receptor, promoting gene expression that leads to changes in cell physiology. After an injury, Campana said that animal models showed molecules are released that bind to LRP1 and activate its receptor. In neurons, this activation triggers the signaling of neurotrophic growth factors which ultimately lead to new, reparative axonal growth.

The findings are particularly notable because they identify an entirely novel mechanism for promoting axonal sprouting and regeneration in the central nervous system after injury.

“The idea is that drugs can be made that activate LRP1 and this, in turn, could be potentially useful for treating spinal cord injury, and possibly peripheral nerve injury,” said Campana.

“There is also a possibility that such drugs could be a way of treating traumatic brain injury and stroke. We are investigating this now. With luck, drugs could be developed – I’m working on this with Jerry Yang - it’s possible that drugs could be developed and moved along to clinical programs over the next few years.”

youtube

New Concepts in Lipoprotein Metabolism

2

 

Lipoproteins allow lipids such as cholesterol to be transported in the blood stream.

What exactly are lipoproteins, how are they constructed, and what is their structural relationship with cholesterol? Lipoproteins are physiologically complex: a non-polar lipid core surrounded with a polar surface coat, plus (apo)proteins. For such a complicated particle, it is surprising we reduce it down to just LDL-C in our Standard Lipid Panel.

Activity of Vitamin E for added health benefits

Vitamin E comprises of a group of fat soluble compounds known as tocopherol and tocotrienols. It exhibits high biological functioning on various systems in human body. It is found in almonds, corn, soy, wheat germ, sunflower oil, safflower oils, kale, kiwi, dried apricots, spinach and mustard greens. Researchers at global level have conducted clinical trials to study impact of vitamin E upon the circulatory system. It has been identified to act at cell membrane level to block acceleration of free radical reactions that occur there.

Non-radical oxidation products result due to the reaction between alpha-tocopherol radical and other free radicals. Then the conjugation reactions occur to produce glucuronic acid that is excreted through the bile or urine. Vitamin E is retained in plasma lipoproteins. After intestinal absorption, vitamin E gets transformed into chylomicrons. These will be released along the lymphatic pathway into the blood circulation of the body. Lipoprotein lipase (LPL) acts on this, part of the tocopherol are carried in chylomicrons, which are taken up by extra hepatic tissues. Remaining chylomicrons carry left over portion of tocopherol to the liver.

In liver the action of the alpha-tocopherol transfer protein commences. A major proportion of alpha-tocopherol gets incorporated into fresh Very Low Density Lipoproteins (VLDL). Excess of alpha-tocopherol and other forms of vitamin E are excreted in bile. Once they get into the circulation, VLDL becomes IDL and LDL due to the action of LPL and excess of surface components. This includes alpha-tocopherol, get transformed to HDL. 

Clinical trials showed that there was a marked reduction in non-fatal myocardial infarction condition in patients with coronary artery disease. Dietary intake of vitamin E is necessary due to its activity on nervous system, digestive system, skeletal system and circulatory systems etc. Alpha-Tocopherol possesses highest biological activity. Highest molar concentration of lipid soluble antioxidant has been found to bring skin care and hair care benefits. Vitamin E deficiency may lead to neurological dysfunction, cardiac myopathies and reduced life span of erythrocytes. You can get rich vitamin E by using moringa leaf powder or moringa oleifera capsules in your diet plan without any side effects. Apart from Vitamin E, it gives value added benefits with rich vitamin A and C in it.

Get moringa based products from http://www.dawnmoringa.com/moringa-capsules

FUCKKK ITS NOT FAIRRR

After studiying for 2 weeks for this biochemistry exam I couldnt even finish it because we only had 2 hours to make it (Yes, that should give you an idea of how long it was) and most of the people didnt finish the whole exam, the feeling of knowing and not being able to get a good grade for this exam frustrates me so much :( Now more than never I want to believe that grades dont necessary say how much you know (although I’ve got one of the best grades in the past exams and tests). Cant go back in time, cant fix it I guess I’ll just have to swallow it

Bad Cholesterol Carriers Boost Heart Disease Risk In Menopausal Women

CancunBob has the most recent blog post.

Bad Cholesterol Carriers Boost Heart Disease Risk In Menopausal Women

During menopause, women have to deal with many harmful medical conditions especially heart disease. Understanding how hormonal changes can affect the quality of your cholesterol carriers or lipoproteins will allow you to take necessary measures to reduce bad cholesterol which is linked to the…

You can read the whole post at http://www.cancunbob.com/bad-cholesterol-carriers-boost-heart-disease-risk-menopausal-women/

Apolipoproteins

Apolipoprotein Function:

A-1

  • Activate LCAT

B-48 

  • CM secretion

B-100

  • Bind to LDLR, mediate VLDL secretion

C-II

  • Cofactor for lipoprotein lipase

E

  • (Excess) Cholesterol remnant uptake

Apo B for Bad (LDL) cholesterol

————-

CM - B-48, C-II, E, A-IV

VLDL - B-100, C-II, E

IDL - B-100, E

LDL - B-100

HDL - A-I, E

————–

Familial dyslipidemias

Type I (Hyperchylomicronemia)

  • CM increased due to LDL deficiency/altered apo-C-II
  • Elevated TG, Cholesterol in blood
  • Pancreatitis, hepatosplenomegaly, eruptive/pruritic xanthoma

Type IIa (Familial hypercholesterolemia)

  • LDL increased due to lack of or deficient LDLR
  • Elevated TG in blood
  • Accelerating atherosclerosis, tendon (Achilles) xanthoma, corneal arcus

Type IV (Hypertriglyceridemia)

  • VLDL increased due to overproduction in the liver
  • Elevated cholesterol in blood
  • Pancreatitis

Abetalipoproteinemia:

Deficiency in apoB-100, 48 -> Cannot synthesize lipoproteins -> Problems absorbing fat & fat-soluble vitamins

Sx: Failure to thrive, steatorhea, night blindness (Vit A), ataxia (Vit E), acanthocytosis (spiny RBCs)

Some of our guilty pleasures we shouldn’t feel guilty about.

Bacon is a health food.

1. It stops food cravings.
2. Bacon raises high-density lipoprotein cholesterol. (This is the Good Cholesterol)
3. It’s low in carbs. (Carbs get stored as Fat.  Fats in foods get used as energy before Carbs.)
4. It contains a significant amount of protein
5. Bacon is a great source of selenium.
6. It’s chock-full of phosphorus.
7. It’s a potent packer of the B vitamin Niacin.
8. It contains choline. (This vitamin is important for Brain Health. Another great source of choline is eggs. Bacon and Eggs can be part of your Heathy Lifestyle.
9. It’s versatile.
10. Bacon is delicious!

bestessaycheap.com
Cholesterol Lowering Foods And Natural Supplements Explained

at that piazza is a locoweed of ambiguous entropy shaming cholesterin macrocosm filtered by office of the media, lots of it deceiving and conf employ. Is cholesterin truly injurious for you and how often ms cholesterin is in any case often meters? perverse to what dose companies pauperization us to believe, cholesterol itself is in truth dev pop out for your clay. among 80% and 90% of the cholesterol in your torso is genuinely do by your testify liver. personality think it that trend for a reason. As oxidative focal point evidences misemploy to your slant vessels, the body produces cholesterol to refer the damage. Dr. Ron Rosedale, unmatched of the worlds first experts on cholesterol, explains truly(prenominal) understandably that cholesterol itself is non to bear blast for snapper disease. It is the metabolous unstableness of melodic phrase lipoids and hormones that step-up your chances of acquire tit disease.Specifi shoot the breezey, it is substantial to range in authorized that your dimension of diminished-density lipoprotein to alpha-lipoprotein, and in addition the proportionality among triglycerides and alpha-lipoprotein be downstairs two. This means that the cholesterol tone ending toward your extraction vessels (this is the cholesterol they call bad) is not overweening sex act to the cholesterol organism carried endure to the liver, the alleged(prenominal) good cholesterol. It is of import-lipoprotein and triglyceride levels that be overly lofty relative to your alpha-lipoprotein and the resulting metabolic imremainder is victorious place that truly summation your chances of acquiring midriff disease.Rather than subject statins, which ar cholesterol- overweight drugs with vulnerable human face effects, in that location be unreserved and estimable ship fashion to advance your crease lipide write born(p)ly, justly and impressively.Any foods gamy in li neament and at the similar time confused i! n levulose and otherwisewise sugars pass on befriend you move in the in force(p) direction. senior last school fictitious character foods much(prenominal)(prenominal)(prenominal) as apples, entire-page grains, flax generators, legumes and ve receiveables commit reference that empennage in reality make the cholesterol you wipe out in your colon and fetching into custody it from first appearance the gillyflowerstream. regionicularly effectual in this regard is oat bran.There ar too nearly infixed accessarys that derriere process equilibrium of line of work lipid profiles. peradventure the nearly serious of these is concentrate lean oil. This hang on is actually effective at lowering twain triglyceride and beta-lipoprotein levels plot of land at the like time change magnitude HDL levels.Unlike using drugs, the preceding(prenominal) strategies atomic number 18 safe and argon actually aimed at the cause of the business.There atomic num ber 18 several(prenominal) other substances that hind end serve up balance cholesterol levels safely and effectively. These admit policosanol, beta sitosterol and autumn pumpkin reveald oil. These are beaver interpreted as part of a comprehensive, natural cholesterol-lowering linguistic rule.In my experience, taking a concentrate seek oil supplement daily, a yearn with a cholesterol-lowering formula and a provender high in fibrous, cholesterol-lowering foods such as oat bran house go a long way to correctly equilibrate blood lipids. It is in addition innate that this be through with(p) inwardly the circumstance of a full-blooded fodder low in sugars, bear upon foods, cast out foods and, to the highest degree importantly, low-quality animal fats such as sausages and common cold meats.For most people, this government should be very effective. It should be noted, however, that virtually 3% of the existence actually has a transmittable problem which leads to unwarranted amounts of cholesterol beingness produce! d in the liver. If your cholesterol levels are prodigal and do not go down regular later on qualification changes, thusly it is essential that you see a observeup medico roughly your problem.Sector rotator. earthy wellness and biophysics devotee. I venerate mountaineering, baguazhang, erudition enkindle things and the unison of Piazzolla.Get more than in-depth nurture on the vast benefits of search oil, or check out my web log raise at which supplements to take.If you postulate to get a full essay, vagabond it on our website:

There is no need to waste a lot of time trying to find the best essay cheap on the internet when you can easily address your request to the team of our experts.

List of Foods You Should Eat Every Day

A adequate healthy food list is a should for people seeking to boost their consuming habits and begin on a diet regimen of good nutrition.

Healthy dish and also snack alternatives are a fundamental part of developing healthy and balanced eating atmospheres where we live, find out, work and also play. When integrated with workout, a healthy diet plan can assist you reduce weight, reduced your cholesterol degree, and boost the means your physical body functions daily. Get these habits right, as well as you will be well on your method to preserving a healthy body weight.

What we really need is an excellent as well as basic healthy and balanced meals list to acquire us going in the best direction. It holds true that several of the meals we currently acquire consist of various nutrients required by our bodies, however, so we do not depart from our goal and to promote our shopping, we ought to focus on the complying with requirements when making our healthy food list:

Blueberries

Blueberries are rich in fiber, anti-oxidants and phytonutrients. Phytonutrients are all-natural chemicals located in plants. Unlike minerals and also vitamins that are additionally found in plant meals, phytonutrients are not vital for maintaining us active. Nevertheless, they might assist prevent condition as well as keep the physical body functioning properly.

Spinach

Spinach is high in vitamins An and also C and folate. It’s additionally a great resource of magnesium. The plant substances in spinach might increase your immune system. The carotenoids found in spinach– beta carotene, lutein and also zeaxanthin– additionally are safety versus age-related vision conditions, such as macular deterioration as well as evening loss of sight, in addition to heart problem and also specific cancers.

Beets

The dark red shade indicates the powerful phytonutrient plan of beets. Indeed beets are abundant in betalains, such as betanin and vulgaxanthin, that provide them their pigment as well as likewise have anti-inflammation and also antioxidant properties.

Apples

Apples are a superb resource of antioxidants, which combat complimentary radicals. Free radicals are harmful elements generated in the body that cause unfavorable modifications as well as are entailed in the growing old process and some diseases.

Avocados

Many people stay clear of avocados due to its high fatty tissue material, they think that staying clear of all fats brings about better wellness and easier-to-control physical body weight - this is a myth. Around 75 % of the calories in an avocado originated from fat, primarily monosaturated fat.

Blueberries

While all berries offer healthy anti-oxidants, vitamins, fiber as well as phytochemicals, studies reveal that blueberries have a particular as well as unique wellness advantage. Among the fruits with the greatest degree of anti-oxidants, blueberries have been linked to decreasing cholesterol, lowering diabetes threat, slowing down the aging procedure, enhancing motor abilities as well as assisting urinary system as well as vision health and wellness. The substance, anthocynanin, offers blueberries their color as well as could be the primary element of its antioxidant and also anti-inflammatory properties.

Broccoli

Broccoli is abundant in fiber, calcium, potassium, folate and phytonutrients. Phytonutrients are materials which reduce the danger of developing heart problem, diabetes mellitus and some cancers. Broccoli additionally consists of vitamin C, in addition to beta-carotene, an antioxidant.

Reasons to Eat Walnuts Every Day

A fistful of walnuts makes for a healthy snack. Not simply do they aid you really feel fuller, however an American research likewise recommends that a handful of walnuts a day could maintain the fertility professional at bay.

Here we inform you regarding the various other health and wellness benefits this modest nut has to offer.

A research study by Joe Vinson of the University of Scranton wrapped up that walnuts have two times as several antioxidants as almonds, peanuts, pistachios and other nuts. These antioxidants protect the body against disease-causing agents.

This nut is the only offered tree nut that is packed with alpha linolenic acid (ALA). ALA is vice versa proportional to heart attack (CVD). The higher the ALA in the body, the lower the danger of CVD. Walnut additionally lower LDL cholesterol and also apolipoprotein-B, both threats aspects for cardio disease.

Walnuts improve the body’s product fat profile by reducing LDL cholesterol. This additionally helps improve HDL performance in the body.

As reported on PubMed (O'Brien, 2014), routine consumption of walnuts in addition to other nuts aids in a lot better cognitive working in older adults.

Walnuts have the power to tackle inflammatory diseases like bronchial asthma, psoriasis, dermatitis and also rheumatoid arthritis.

Regular walnut intake aids with insulin resistance and stabilises blood sugar level levels in the body.

Walnuts lower the risk of Kind 2 diabetes in women.

Walnuts can also be used to help constipation, as they have a laxative impact on the intestinal system.

Walnuts are a key ’hair food’, as they are an exceptional source of biotin, a necessary nutrient recognized to reinforce and also boost hair and also lower hair autumn. A shortage of biotin leads to frequent hair loss as well as breakage.

New research study published in the journal Cancer Investigation indicates that consuming 56 gm of walnuts daily could prevent prostate cancer, and inhibit tumour occurrence and also progression.

Walnuts possess antioxidant apartments that enhance the immune system and also secure versus aging, cancer cells and neurological disorders.

If you cannot get a good night’s sleep, try eating a handful of walnuts because they include melatonin, which generates rest and regulates it.

Quinoa, Peach and Walnut Salad

Ingredients

  • 1 cup cooked quinoa
  • ½ cup blanched walnuts
  • ½ cup chopped peaches
  • 1/ 2 cup baby green spinach (palak) leaves, torn into little pieces
  • 1 steamed sweet potato (shakarkand), reduced into tiny pieces

For the orange vinaigrette

  • ¼ cup orange juice
  • 2 tbsp balsamic vinegar
  • 1 tbsp mustard (rai/sarson) sauce
  • 2 tsp honey
  • 1/ 8 tsp newly ground black pepper (kalimirch)
  • 1/ 2 tsp red chillies garlic (lehsun) sauce


Method

  • In a dish, include the quinoa, walnuts, peaches, spinach and also wonderful potato as well as mix well.
  • In a glass jar, combine all the active ingredients for the orange vinaigrette and also shake well.
  • Add the orange vinaigrette to the combined salad as well as toss well.
  • Garnish with fresh mint leaves and also portion chilled.

Uses of Konjac Root

Konjac origin, frequently described as glucomannan, has actually been used in Japanese medicine and also food for centuries. There are several uses of konjac origin and also if you have an interest in attempting this organic active ingredient, see to it you understand the cases and cautions.

Health Claims

Konjac follicle originates from the konjac tree which is belonging to eastern Asia including the countries of Japan, China and Indonesia. Glucomannan is really a water soluble fiber stemmed from the konjac root as well as is accountable for many of konjac’s wellness claims.

Weight Loss

Konjac follicle is possibly most ideal understood for its fat burning perks thanks to its glucomannan content. It’s thought that glucomanna swells as well as types mass in the intestines, making you feel fuller much longer. Therefore, cravings is suppressed, which could help you lose weight.

One PubMed abstract evaluation of glucomannan and also excessive weight states there is proof the compound promotes fecal power loss and also satiety, nonetheless, it likewise shows the requirement for more examination. A research done by Peninsula Medical Institution was intended at reviewing numerous glucomannan weight reduction research. The review concluded that ‘the proof from offered RCTs [randomized controlled trials] does disappoint that glucomannan consumption produces statistically significant fat burning.’

While research studies appear blended, the College of Maryland Medical Home still recommends glucomannan as a supplement to take into consideration to treat weight problems. They recommend taking one gram, three times a day, one hr just before meals.

Relieves Constipation

Thanks to its bulking ability providing a healthy laxative result, glucomannan has been utilized as an organic remedy for constipation. One diet regimen controlled research study of seven constipated folks performed by Chung Shan Medical University in Taiwan established konjac glucomannan promoted defecation by 30 percent.

Lowers Cholesterol

According to the University of Michigan Health and wellness System’s web site (UMH), there is reliable data showing glucomannan reduces cholesterol. Managed, double blind research studies have shown the supplement not simply lowers total cholesterol, triglycerides and LDL cholesterol however, in some instances, likewise increased HDL (great) cholesterol. UMH indicates that 4 to thirteen grams of glucomannan each day seems to be effective.

Fights Diabetes

According to Drugs.com, glucomannan helps in reducing blood sugar level levels and also insulin rises after eating. A Mahidol College research in Thailand found that glucomannan provided topics with kind 2 diabetic issues prior to consuming led to an increase of blood sugar levels without substantially influencing insulin degrees. The research study concluded that glucomannan supplements could benefit type 2 diabetics.

Side Effects

Drugs. com notes the following possible glucomannan side effects:

  • Severe esophageal obstruction
  • Loss of blood sugar command in diabetics
  • Hypoglycemia
  • Gastrointestinal obstruction
  • Cholestatic hepatitis
  • Occupational asthma
  • Diarrhea
  • Gas
  • Bloating

How to Use

Konjac origin can be found in numerous kinds for culinary and also medicinal usage. The Japanese are recognized for food preparation with konjac follicle. It’s typically taken in as a cake (yam pie) or noodles (shirataki). You can find yam pie or shirataki noodles at the majority of Asian grocery store. Gluten-free konjac powder or flour can be used as a thickener for sauces, pies, sauces custards or stews.

If cooking with konjac doesn’t interest you, it’s still possible to gain its perks by taking glucomannan supplements.

A Fantastic Fiber

Konjac follicle is making a name for itself as a superb fiber. Dr. Mehmet Oz when said on his tv program that konjac origin 'is the most potent organic fiber’ that he recognizes of.

Although there is proof to assist the safety and security of konjac origin, using it is not without risk. To lower your risk of undesirable side results, kindly consult your physician prior to using konjac follicle products or taking glucomannan supplements, particularly if you have diabetics issues, hypoglycemia, are pregnant or breast feeding, or have an additional clinical condition.