Fig. 7. Effect of PDGF-BB on microfilament reorganization, as revealed by phalloidin staining. Quiescent mesonephric mesenchymal cells (A) were stimulated for 15 minutes (B) with PDGF-BB (10 ng/ml). Note that treated cells exhibit a rapid change in microfilament reorganization and in cellular morphology (phalloidin staining at the leading edge of the cell and extensions of lamellipodia). Bar, 20 μm.
The role played by PDGF in testis morphogenesis is still incompletely understood. The present study investigates the expression and potential role of platelet-derived growth factor-BB (PDGF-BB) and its receptor, PDGF receptor β (PDGFR-β), during mouse testis cord formation, and the possibility that the growth factor may be involved in the migration to the gonad of mesenchymal cells of mesonephric origin.