Kayser-Fleischer-Rings are brownish-yellow “rings” encircling the iris. They are caused by copper deposition in part of the cornea and are a sign of liver diseases, particularly caused or accompanied by Wilson’s Disease.
tryptophan deficiency, leads to niacin deficiency, pellagra-like dermatosis
HFE gene, C282Y MC mutation, chromosome 6, unrestricted reabsorption of Fe+ in SI, iron deposits in organs, bronze diabetes, DM1, malabsorption, cardiomyopathy, joint degeneration, increased iron, ferritin, TIBC. Complications: liver cirrhosis, hepatocelullar carcinoma
due to B6 deficiency (defective Cystathionine synthase) or due to B9,B12 deficiency (defective Homocysteine Methyltrasnferase), dislocated lenses (in & down), DVT, stroke, atherosclerosis, MR.