I’m a big-brother, I have a little sister. But I don’t have a younger brother. So honestly, I’ve come to feel more like an older brother being in the set and working with Jared. Because he and I are very close friends and have that brother mentality of taking care of each other. He’s really like a brother. And I’m four years older than him so it was kind of natural to fall into that role, even though he’s bigger than I am! So it wasn’t difficult to achieve.
—  Jensen Ackles - jibcon 2012 M&G [X]
I think there’s an enormous amount of guilt that Dean carries around for many things. That’s just a part of who he is and what keeps him running. It’s his cross to bear. The guilt of losing his father, the guilt of losing Bobby, the guilt of not being able to protect his brother all the time. When all those things add up, life is pretty grim for Dean. But yet he’s still able to smile and turn on the radio and eat cheeseburgers. He’s got that vulnerability about him and that strength about him. That’s what makes him such a great character to play. I think that Dean needs that burden [of being a big brother and hero] in his life to validate him. I think he gravitates towards the painful version of himself and takes on the heavy responsibility because it makes him who he is.
—  Jensen Ackles - jibcon 2012

“It’s kinda nice to be able to just sit here with you and not have to talk”.© Misha

“I love you Misha, I mean, honestly, from the bottom of my heart”. © Jensen

“When I first did it (staring) I was imagining that I was like looking into his soul”. © Misha

“He’s so cute you know? Like one of those little teddy bears, you just wanna stuff him in your pocket and take him home with you”. © Jensen

“I have loved doing the intimate scenes with Dean or Jensen over the years the most. There’s something about that dynamic that just seems to work really well”. © Misha

“It’s nice because I feel like there’s this angel standing over me”. © Jensen

“It warms the cockles of my heart. Words chosen carefully”. © Misha

“Misha is the funniest thing that’s ever happened to me”. © Jensen

“It was like being in the water without a life jacket. Scary”. “What is?” “Not being able to see him”. © Misha

.. picking one randomly that I will never forget, in the pilot episode, where the brothers are in the library, looking in the monitor and studying their case of the woman in white, that was actually the very first day of production on supernatural […] I’ll just never forget it, ‘cause that was day one and he and I were already having a brother-like scene where I think you reach for the keyboard and I slap your hand away. That was instant and I knew then, that we had something that was .. that had potential. That we had a report that could go a long way with the show.
—  Jensen Ackles on the scene he’ll never forget - jibcon 2012 [vid]