I’m usually pretty particular about the sorts of traits that get assigned as humanity’s “special thing” in sci-fi settings, but I have to admit that I have a weakness for settings where the thing humanity is known for is something tiny and seemingly inconsequential that it wouldn’t normally occur to you to think of as a distinctive trait.
Like, maybe we have a reputation as a bunch of freaky nihilists because we’re the only species that naturally has the capacity to be amused by our own misfortune.
Alien: Why are you happy? You’ve been seriously injured!
Human: *struggling to control laughter* Yeah, but I can imagine what that must have looked like from the outside, and it’s pretty hilarious.