Nearly 80 percent of peanut-allergic preschool children successfully
incorporated peanut-containing foods into their diets after receiving
peanut oral immunotherapy (OIT), a clinical trial has found. Peanut OIT
involves eating small, gradually increasing amounts of peanut protein
daily. Low-dose and high-dose OIT were safe and equally effective at
suppressing allergic immune responses to peanut, investigators found.
The work was partly supported by the National Institute of Allergy and
Infectious Diseases (NIAID) and the National Center for Advancing
Translational Sciences, both part of the National Institutes of Health.
BP Vickery et al. Early oral immunotherapy in peanut-allergic preschool children is safe and highly effective. Journal of Allergy and Clinical Immunology, August 2016 DOI: 10.1016/j.jaci.2016.05.027
Inflammation is a key set of processes typically
used to help clear pathogens or other harmful threats. But, it can be
detrimental if it becomes chronic, damages healthy tissue, and leads to disease
progression. We’re happy to announce our new Inflammation Webpage, which covers
stages of inflammation, acute vs. chronic inflammation, disease states, and
Multiple Sclerosis (MS) is a disease in which the immune system eats away at the protective covering of nerves.
In MS, resulting nerve damage disrupts communication between the brain and the body.
Multiple sclerosis causes many different symptoms, including vision loss, pain, fatigue, and impaired coordination. The symptoms, severity, and duration can vary from person to person. Some people may be symptom free most of their lives, while others can have severe chronic symptoms that never go away.
Physical therapy and medications that suppress the immune system can help with symptoms and slow disease progression.
All you see is a bright streak of red as the Northern Cardinal flits across the backyards of North America with their classic bird call carrying on. These birds are relatively common and according to new research, they might be playing a big role in keeping ecosystems, including our own, healthy.
Doctors successfully cured babies and toddlers of their
peanut allergies by feeding them small doses of peanuts, according to a
study published Wednesday in the Journal for Allergy and Clinical Immunology. The treatment, know as “oral immunotherapy,” involves
introducing small doses of peanuts (or any substance) into the subjects’
diets and gradually increasing the dose. Despite the therapy’s success rate, it remains a controversial method.
Flesh-Eating Infections in Rheumatoid Arthritis Patients Spur New Discovery Patient data reveals the crucial role immune molecule interleukin-1beta plays in sensing streptococcal infections and provides new insights for the development of targeted autoimmune disease therapies with fewer side effects
Rheumatoid arthritis patients taking medications that inhibit interleukin-1beta (IL-1beta), a molecule that stimulates the immune system, are 300 times more likely to experience invasive Group A Streptococcal infections than patients not on the drug, according to University of California San Diego School of Medicine researchers. Their study, published August 19 in Science Immunology, also uncovers a critical new role for IL-1beta as the body’s independent early warning system for bacterial infections.
“The more we know about each step in the body’s immune response to bacterial infections, the better equipped we are to design more personalized, targeted therapies for autoimmune diseases — therapies that are effective, but minimize risk of infection,” said senior author Victor Nizet, MD, professor of pediatrics and pharmacy at UC San Diego School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences.
IL-1beta is a molecule that stimulates an immune response, calling white blood cells to the site of an infection so they can engulf and clear away invading pathogens. The body first produces the molecule in a longer, inactive form that must be cleaved to be activated. The scientific community long believed that only the body itself could cleave and activate IL-1beta, by employing a cellular structure known as the inflammasome. But in experiments using cell cultures and mouse models of infection, Nizet and team found that SpeB, an enzyme secreted by strep bacteria, also cleaves and activates IL-1beta, triggering a protective immune response.
School in two weeks and worried I'll screw it up again :(
I really need to ace school this year since its my last chance to get into a program I really want to. I’m always confused where I’m going wrong with things though so if anyone has any suggestions please let me know! I’m studying microbiology and immunology this year as a 3rd year science undergrad student.
Thank you!!! Just want more tips to see how I should change things up. Gotta think before my life begins to get busy again haha
The inflammatory response is an integral part of the innate immune mechanism that is triggered in response to a real or perceived threat to tissue homeostasis, with a primary aim of neutralizing infectious agents and initiating repair to damaged tissue. By design, inflammation is a finite process that resolves as soon as the threat of infection abates and sufficient repair to the tissue is…
Concerns over the Zika virus have focused on pregnant women due to mounting evidence that it causes brain abnormalities in developing fetuses. However, new research in mice suggests that certain adult brain cells may be vulnerable to infection as well. Among these are populations of cells that serve to replace lost or damaged neurons throughout adulthood, and are also thought to be critical to learning and memory.
The study, led by scientists from University of California San Diego School of Medicine, The Rockefeller University and La Jolla Institute for Allergy and Immunology, is published August 18 in Cell Stem Cell.
“This is the first study looking at the effect of Zika infection on the adult brain,” said co-senior author Joseph Gleeson, MD, professor of neurosciences and pediatrics at UC San Diego School of Medicine, adjunct professor at Rockefeller and Howard Hughes Medical Institute investigator. “Based on our findings, getting infected with Zika as an adult may not be as innocuous as people think.”
Although more research is needed to determine if this damage has long-term biological implications or the potential to affect behavior, the findings suggest the possibility that the Zika virus, which has become widespread in Central and South America over the past eight months, may be more harmful than previously believed.
“Zika can clearly enter the brain of adults and can wreak havoc,” said co-senior author Sujan Shresta, PhD, professor at the La Jolla Institute of Allergy and Immunology. “But it’s a complex disease — it’s catastrophic for early brain development, yet the majority of adults who are infected with Zika rarely show detectable symptoms. Its effect on the adult brain may be more subtle, and now we know what to look for.”
Early in gestation, before our brains have developed into a complex organ with specialized zones, they are comprised entirely of neural progenitor cells. With the capability to replenish the brain’s neurons throughout its lifetime, these are the stem cells of the brain. In healthy individuals, neural progenitor cells eventually become fully formed neurons, and it is thought that at some point along this progression they become resistant to Zika, explaining why adults appear less susceptible to the disease.
Pictured: Zika virus (shown in green) can infect adult mouse brains.
On Wednesday I had my Biology exam, so after that I was able to chill for a bit 😊 picked up some books from the library, then went outside to sit and read this book about immunology in the beautiful weather! 😁
So so important to remember to take breaks while studying for an extended period of time, so that your brain is able to relax. Take some time out to do the things you love, be with the people you love, and then go back to studying because your brain will be able to see things differently and soak information up much better! Don’t overwork and then burn out - that’s the worst thing ever.
So, this is another one where I don’t even need to finish it to recommend it. It’s all about gut health and how it relates to overall health, but especially to brain health. Highly recommended for anyone with physical or mental issues of any kind. So far I’ve been quite amazed at the science behind how much your gut health impacts pretty much everything else in your body. Definitely check it out.
well apparently Peter from Tangled Webs does, since the fact that I wrote that fic years ago but immediately disliked Root for her similarities to him happened… but other than that I don’t really think so. Unless you count characters from poorly-written stories in my youth that pester me for better stories to be written about them, in which case there are a ton, heh
24) have you ever become an expert on something you previously knew nothing about, in order to better a scene or a story?
Oh, man, so many things. SO MANY. I did a ton of research on immunology for the Searching Ceremonies (then ignored half of what I learned in favor of Drama). Researched piloting and plane crashes for TSOIP. The way people react to and abuse rape victims for ISUAD (especially Steubenville). And that’s not even going into all the psychological research I’ve done on PTSD, domestic abuse, self-harm, ADD, Stockholm Syndrome, etc. Or all the “detective” things that would probably get me in trouble, like how to clone cell phones, buy/assemble RFID emulators, commit arson… I research a lot is what I’m saying here. XD
Plus writing Stiles in TSOIP taught me a lot about cooking that I probably should have known but didn’t, LOL