immunolec2

Colony stimulating factors

- subclass of cytokine superfamily

- protein factors able to stimulate the production of one or more colony type in semi-solid cultures of bone marrow or other haematopoietic tissue

- IL-3, IL-5, GM-CSF, Epo, Tpo, G-CSF, IL-6, LIF, OSM, M-CSF, SCF, FLT-3L

- produced by activated macrophages/T-cells and other cell types

- bind specific receptors

  -> some have receptor subunits in common

  -> stimulate signal transduction leading to transcription factor activation enhancing proliferation, viability, differentiation