Researchers find new biomarker for brain cancer prognosis
In combination with IDH mutations or several other biomarkers, SHOX2 expression helped to identify subgroups of patients with a good prognosis even though other biomarkers had predicted a bad prognosis.

DALLAS - Dec. 6, 2016 - Researchers at UT Southwestern Medical Center have found a new biomarker for glioma, a common type of brain cancer, that can help doctors determine how aggressive a cancer is and that could eventually help determine the best course of treatment.

Researchers from the Harold C. Simmons Comprehensive Cancer Center found that high expression of a gene called SHOX2 predicted poor survival in intermediate grade gliomas.

“As an independent biomarker, SHOX2 expression is as potent as the currently best and widely used marker known as IDH mutations,” said Dr. Adi Gazdar, Professor of Pathology in the Nancy B. and Jake L. Hamon Center for Therapeutic Oncology and a member of the Simmons Cancer Center.

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Three letters - two handwritten and one typed - written by George Harrison in reply to a fan, Dianne, in 1963. Along with the letters, Bonhams is also selling autographs, three unpublished photos (taken by the fan in Worcester, presumably on 28 May 1963) - including this one of George - and two ticket stubs.

The letters read:

Dear Dianne,

Thanks for your letter. I haven’t really got much time to answer, but I thought I had better try now, otherwise I’ll never do it.
My brothers are Peter 22 Harry 25
parents Louise and Harry
Car Ford Zephyr.
Harry and the box are friends of ours. no favourite food in particular.
Cheerio love from
George Harrison
(John is married and has been since before we started making records.)

* * *

23rd July, 1963
Dear Dianne,

Thanks for your letter and also the jelly babies which John and I ‘scoffed’. As I ate most of the jelly babies the others said I should write to you.
Unfortunately, as we receive thousands of letters each week, it is extremely difficult for us to read through all of them never mind reply to them all, as much as we would like to.
We really appreciate your comments concerning our group and as the reception we received at Worcester was ‘fab,’ we hope that it won’t be too long before we will be able to come again.
I am enclosing life-lines of the four of us which might interest you.
John, Paul and Ringo send their love.
Best wishes,
P.S. Sorry the letter had to be typed but we are extremely busy.

* * *


Dear Dianne,

Thanks for the letter. I taught myself to play the guitar, my car number is L.T.U. 409.
I can speak a little German. My parents names are Louise, and Harry, and I have visited Germany, Spain + Holland.
Billy Fury must be 23 too!

George Harrison and his father, Harold, having breakfast at 174 Mackets Lane, Liverpool, 7 December 1963. Photo © Mirrorpix. (A grainy-quality scan has previously been posted at thateventuality here.)

“The Beatles returned to Liverpool on 7 December 1963 for a concert at the Liverpool Empire and to record an episode of ‘Juke Box Jury’ for TV. Using the same audience from The Beatles Northern Area Fan Club performance, the group was filmed between 2.30 p.m. and 3.15 p.m. for broadcasting that evening. About thirty minutes later they taped a concert segment for ‘It’s The Beatles’, followed by an interview for 'Top of the Pops’. They then made a mad dash up London Road to the Odeon Cinema for two more performances that evening.

It was just another crazy day in the life of The Beatles as their fame spread across the United Kingdom. However, for Michael Turner, a six-year-old boy, it was a most memorable day. Michael’s sister Flora remembers it well.

'Michael was nearly seven. He loved all The Beatles, but most of all, he loved George Harrison,’ Flora said. 'So, as the boys were coming to Liverpool to do “Juke Box Jury” at the Empire, we decided to get him tickets for his birthday’.

Flora and her friends stood in line all night waiting for tickets. They purchased for tickets each, including one for Michael. Unfortunately, a few days before the concert, Michael came down with the measles, which put an end to his Beatles dream. 'He was heartbroken’, Flora recalled.

Flora knew where Louise and Harry Harrison lived and hit on a novel idea - send them a telegram explaining Michael’s predicament. The day of the concert Flora was in her room getting ready for the big show, when there was a knock on the door. Moments later Flora’s mother told her that Mrs. Harrison was asking for her.

'So, off I went - rollers in my hair and all,’ Flora said, 'At the door was a woman, wearing a greyish coat and holding something in her hand. “We received your telegram,” she said, “and George wanted you to have this!” I invited her in, but they were on their way to the theatre. “The boys are in the car”, she added.

'The boys are in the car? They certainly were. Smiling and waving at me - in my rollers. You can imagine how I felt. I waved back and thanked George’s mum. She was a nice lady.’

Louise delivered an autographed photo from all four Beatles, dedicated to Michael. They all wished him well.

That selfless act made lifetime fans out of both Michael and Flora. 'It cheered a sick little boy when he felt disappointed - and not matter what is written about them, I will never forget what George’s mum, George and the other Beatles did’, Flora said.” - Liddypool: Birthplace of The Beatles by David Bedford [x]

Nine questions for director Sean Mathias

Ian McKellen and Patrick Stewart on stage at the camera rehearsal for the NT Live broadcast of No Man’s Land, directed by Sean Mathias.

Sean Mathias, director of No Man’s Land, first saw the play on its opening night in 1975. Now he’s directing the production, with Ian McKellen and Patrick Stewart as Spooner and Hirst, playing to an audience in Wyndham’s Theatre and an audience worldwide for its National Theatre Live cinema broadcast.

What inspired you to direct No Man’s Land?

It’s a play I’ve wanted to do for many years. I tried to do it twice over the last 20 years, before this production, but the auspices did not align on either occasion. And then Patrick Stewart asked me to do it. While he was in Waiting for Godot, he said he would love me to direct him in No Man’s Land. That’s what started the ball rolling – and it was third time lucky.

Why did you want to pair the play with Samuel Beckett’s Waiting for Godot?

The pairing came about in a more pragmatic way. Patrick wanted to do No Man’s Land but not do Godot again, and Ian wanted to do Godot in America but wasn’t convinced that he should do No Man’s Land because he felt that John Gielgud and Ralph Richardson, the original Spooner and Hirst in the 1975 production, had left such a strong mark on it. So it was a matter of give and take.

But they are also a brilliant pairing of plays, because Beckett was a big influence on Pinter’s life: Pinter sent all his plays to Beckett for his opinion. You also need four actors for each play – so the two other characters could be played by the same actors. So suddenly it all seemed to make a lot of sense – both artistically and pragmatically.

Ian McKellen and Owen Teale in No Man’s Land. Photo by Johan Persson

Do you have a particular favourite line or exchange from No Man’s Land?

‘What happened to them? What happened to our cottages? What happened to our lawns?’

The line sounds so banal, so ordinary, very prosaic – but it turns out to be a great statement about loss. What has happened to those pasts, to the accoutrements of life. What has happened to one’s success, to one’s family, to one’s history. I think the play is full of similar lines. Pinter uses these illustrations a lot which on the surface seem to be about one thing but actually take you down another path altogether.

How does directing a play by Pinter differ from directing the work of any other playwright?

It’s Pinter’s precision. The play is so precise and delicate. It’s full of nuance and full of poetry. But you have to be very delicate with it. You can’t manhandle this play, you can’t treat it too roughly.

Pinter notoriously includes lots of stage directions for his characters. As a director, is that challenging or helpful?

It’s fairly helpful for a director. The problem with stage directions is that they’re often not the author’s, they are added in over years by stage managers; but if you know that they are the author’s intention that’s a different matter.

Apart from No Man’s Land, what has been your favourite production to direct?

That’s tough. There have been a few. Les Parents Terribles (1994, National Theatre) by Jean Cocteau would be one of them. A Little Night Music (1995, National Theatre). Waiting for Godot (2009, Theatre Royal Haymarket). Those three stand out.

Damien Molony, Patrick Stewart, Owen Teale and Ian McKellen in No Man’s Land. Photo by Johan Persson

What advice would you give to aspiring directors?

Read as many plays as you can. Read as much as you can, and see as much theatre as you can.

What’s next after No Man’s Land?

I’m doing The Exorcist in the West End next year, and I’m doing a new play by Martin Sherman in New York.

Hirst and Spooner drink a lot of alcohol over the course of No Man’s Land. Of their drinks of choice, which is yours – whisky or champagne? 


National Theatre Live will broadcast No Man’s Land to cinemas around the UK and internationally on 15 December 2016, with many venues showing Encore screenings after this date. Find your nearest venue and book.

Bookmas Series: 6th December 2016
A review by Steve Moore (www.stevemoorephotography.co.uk)

The Unlikely Pilgrimage of Harold Fry – Rachel Joyce

Rating: 9/10

I read this book solely based on the title! – I had never heard of it before and never heard of the author. A classic case of judging a book by its cover!

From the small review snippets on the back I knew that it wasn’t going to be the kind of book I would normally read (fast paced action thriller type books) but I was totally intrigued by the title.

It is a very slow and gentle novel but I mean that in the best possible way! You follow the main character, Harold Fry, in an adventure that for him, a rather melancholy and slightly inadequate man, is so far removed from his normal everyday life. Despite his rather banal nature I like the way that the author ensures you get right behind him in his quest and are always interested to find out what next will happen to him. Harold’s past is gradually revealed to you and you slowly get the feeling that there is more going on than there appears to be on the surface. This is not the kind of book that incorporates unexpected plot twists but it doesn’t need them – it is an original and captivating tale and I was pleasantly surprised by how engrossed I became in Harold’s pilgrimage.

This was a pleasure to read, a very charming tale of the ordinary doing extraordinary things. I feel it deserves my rating of 9/10 and I would recommend it to anyone no matter what genre of books they would normally read!


Tess Larson and Frankie Cruz in Conviction Season 1 Episode 9 | A Different Kind of Death 

‘I did find something interesting in hit man Harold’s financials. There was a total of almost 38,000$ worth of deposits into Harold’s account around the time Tom was shot, and each of those deposits was just under 2,000$. - But that’s 19 different checks. - Not checks…money orders. Money orders are anonymous if the amount is below 2,000$. Above that, a suspicious activity report would’ve been filed.’

hiiiiiiiiii guys so this is my first follow forever! i thought it’s almost christmas and new year so i’d finish off the year with this. lots of love <3


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big big thanks to @aboutthefantasyinmyhead for the edti!

In 1066, William the Bastard decided he wanted England`s throne. He gathered troops and challenged the standing king, Harold Godwinson, near Hastings. Leading his men against Harold`s troops and fighting against them, William eventually proved successful when Harold fell in battle and became known to history as William the Conqueror.

In 1461, Edward, Earl of March, led his troops against the standing king Henry VI`s troops. His father was dead by then, as was his younger brother Edmund, having been kille after a previous battle. In something that can be best called a bloodbath on both sides, Edward led his men at the frontlines and won his victory to become king. He repeated the same ten years later, fighting two battles in the front lines to gain back his throne. He eventually died in his bed, a successful king and warrior.

In 1471, seventeen-year-old Edward of Lancaster, apparently against his mother`s wishes, decided to fight in battle to gain back his father`s throne and his borthright against Edward IV. According to all contemporary accounts, he wanted to prove his metle despite his mother warning him of the dangers, and he died honourably in battle because of this.

In 1487, John de la Pole, having decided to declare against the king who had killed his uncle and thrown him off the throne, fought in the front lines in battle against him, leading German and Irish mercenaries and English rebels. He was in his early twenties and died honourably in battle.

In 1147, fourteen-year-old future Henry II decided to declare against the current king and win back his birthright, preparing to fight in battle against them, being fully aware he would risk his life.

But I am supposed to believe that Henry VII simply gathering an army and then not fighting in it - and he did not fight in it, the best a near-contemporary source days he wanted to but didn`t - was already brave in itself? Even though he didn`t participate in the bloody battle he explicitly had brought on with his thirst for power? And I am to think it was not cowardly to keep away from said battle he had himself caused for very base reasons because after all it could be dangerous for his life?

All the others throughout history faced the same dangers, sometimes in situations they had not brought on themselves, and still did not quail and not fight. Flounting conventions so for fear of his life was cowardly. His life was not more important than all those of the others mentioned, just because he was Henry.

It is okay for Henry to have been cowardly. He had other virtues. But he was not brave for bringing an army, nor is “he could have died” an excuse why he flounted conventions to protect himself. He didn´t fight at Bosworth and he didn`t fight at Stoke, and he can fairly be called coward for that.